Effects of neuropeptide Y on lung vascular permeability in the pulmonary circulation of rats.
Eur J Pharmacol
; 256(2): 227-30, 1994 Apr 21.
Article
em En
| MEDLINE
| ID: mdl-7519559
ABSTRACT
The effects of neuropeptides on the capillary filtration coefficient in the vessels of the pulmonary circulation were examined, using isolated lung perfusion preparations from rats. Neuropeptide Y and neurokinin A elevated the filtration coefficient, and calcitonin gene related peptide diminished it. Neurotensin and substance P did not affect the value at concentrations less than 10(-7) M. The number of extravasated carbon particle deposits subsequent to tracheal application of neuropeptide Y during spontaneous respiration increased in a dose-dependent manner. From these results, we conclude that neuropeptide Y may increase vascular permeability in the pulmonary circulation.
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Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeo Y
/
Neuropeptídeos
/
Permeabilidade Capilar
/
Circulação Pulmonar
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Japão