Novel inhibitors of poly(ADP-ribose) glycohydrolase.
Biochim Biophys Acta
; 1158(3): 251-6, 1993 Nov 28.
Article
em En
| MEDLINE
| ID: mdl-8251524
ABSTRACT
The inhibitory effects on poly(ADP-ribose) glycohydrolase purified from human placenta of three classes of chemically defined tannins; gallotannins, ellagitannins and condensed tannins, were examined in vitro. Oligomeric ellagitannins were found to be most potent inhibitors of poly(ADP-ribose) glycohydrolase, their potencies increasing with increasing number of monomeric residues (dimer < trimer < tetramer). Monomeric ellagitannins and gallotannins were less inhibitory. Condensed tannins, which consist of an epicatechin gallate oligomer without a glucose core, were not appreciably inhibitory. A structure-activity study showed that higher-order conformations of the conjugates with glucose of hexahydroxydiphenoyl and valoneoyl groups, which are unique components of ellagitannins, cooperatively potentiated the inhibitory activity.
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Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Taninos
/
Taninos Hidrolisáveis
/
Inibidores Enzimáticos
/
Glicosídeo Hidrolases
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Japão