Delayed production of nitric oxide contributes to NMDA-mediated neuronal damage.
Neuroreport
; 4(5): 566-8, 1993 May.
Article
em En
| MEDLINE
| ID: mdl-8513140
ABSTRACT
Exposure of primary murine cortical neuron cultures to N-methyl-D-aspartate (NMDA) resulted in neuronal death as evidenced by release of lactate dehydrogenase (LDH) into the media. The addition of N-nitro-L-arginine (N-Arg) protected the neurons from death in a concentration-dependent manner when added after the NMDA, but not when the N-Arg was present with the NMDA. Protection by N-Arg was lost if L-arginine containing media was added to the cultures prior to the addition of the N-Arg. Treatment of the neurons with kainate prior to NMDA reduced subsequent NMDA-induced damage which was not prevented with N-Arg. These results suggest that delayed production of nitric oxide (NO) contributes to NMDA-induced neuronal damage in culture.
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Base de dados:
MEDLINE
Assunto principal:
N-Metilaspartato
/
Neurônios
/
Óxido Nítrico
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article