Determination of Phenmetrazine in urine by gas chromatography-mass spectrometry.
J Anal Toxicol
; 20(5): 277-80, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8872234
ABSTRACT
A sensitive and simple gas chromatographic--mass spectrometric method is described for the determination of the central nervous system (CNS) stimulant phenmetrazine in urine. The extraction and derivatization were combined into a single step with isooctane and methyl chloroformate. The limit of quantitation was 0.05 micrograms/mliters urine, and the method was linear up to 100 micrograms/mliters. The coefficients of variation (CV) for within-day runs were 1.2% and 2.4% (n = 5) for two controls containing 1.0 micrograms/mliters and 50 micrograms/mliters, respectively. During a six-month period, the same controls showed CVs of 9.1% and 8.7%, respectively (n = 40), indicating a somewhat lower between-run precision. Phenmetrazine was present in 83 out of 3000 urine samples that were screened for CNS stimulants during this period, and the concentrations ranged from 0.5-370 micrograms/mliters.
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Base de dados:
MEDLINE
Assunto principal:
Fenmetrazina
/
Urinálise
/
Estimulantes do Sistema Nervoso Central
/
Cromatografia Gasosa-Espectrometria de Massas
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Suécia