Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
Nat Genet
; 15(4): 356-62, 1997 Apr.
Article
em En
| MEDLINE
| ID: mdl-9090379
ABSTRACT
Deletions involving regions of chromosome 10 occur in the vast majority (> 90%) of human glioblastoma multiformes. A region at chromosome 10q23-24 was implicated to contain a tumour suppressor gene and the identification of homozygous deletions in four glioma cell lines further refined the location. We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5.5-kb mRNA. The predicted MMAC1 protein contains sequence motifs with significant homology to the catalytic domain of protein phosphatases and to the cytoskeletal proteins, tensin and auxilin. MMAC1 coding-region mutations were observed in a number of glioma, prostate, kidney and breast carcinoma cell lines or tumour specimens. Our results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 10
/
Genes Supressores de Tumor
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Proteínas Tirosina Fosfatases
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Glioblastoma
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Monoéster Fosfórico Hidrolases
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Proteínas Supressoras de Tumor
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Mutação
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos