Tumor suppressive action of indomethacin is NK-cell-independent.
Anticancer Res
; 17(5A): 3403-7, 1997.
Article
em En
| MEDLINE
| ID: mdl-9413179
ABSTRACT
This study was undertaken to determine whether NK-cells constitute a necessary mediator for the suppression of tumor growth by indomethacin. C57Bl mice with a methylcholantrene (MCG 101) tumor were studied. Indomethacin treatment was provided by daily subcutaneous injections (1 microgram/g body weight). NK-cells were depleted by treatment with a monoclonal antibody to NK1.1. Consecutive indomethacin injections prolonged survival in tumor bearing animals. Indomethacin was equally effective in animals with intact NK-cells as in NK-cell-depleted animals. Further, the MCG cells were apparently insensitive to the lytic activity of NK-cells in vivo. Thus, the clearance of intravenously injected MCG cells from lungs was not affected by depletion of NK-cells in vivo; in contrast, the corresponding clearance of NK-cell-sensitive YAC-1 lymphoma cells was strikingly reduced by the depletion of NK-cells. Our data suggest that NK cells are not a necessary mediator for the suppression of tumor growth by indomethacin.
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Base de dados:
MEDLINE
Assunto principal:
Sarcoma Experimental
/
Células Matadoras Naturais
/
Indometacina
/
Antineoplásicos
Idioma:
En
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Suécia