Effects of radiographic contrast media on leukocyte phagocytosis.
Acad Radiol
; 1(3): 249-52, 1994 Nov.
Article
em En
| MEDLINE
| ID: mdl-9419494
ABSTRACT
RATIONALE AND OBJECTIVES:
Differences in leukocyte phagocytosis following exposure to different classes of radiographic contrast media (RCM) may help in the development of less toxic alternatives and be useful as a guide to contrast selection in certain patient groups. The effect of RCM on leukocyte phagocytosis of Escherichia coli was examined.METHODS:
Cell population phagocytosis and individual cell phagocytic activity were assessed in a control group and in samples exposed both to the ionic RCM diatrizoate and ioxaglate and to the nonionic RCM iohexol and iotrolan by using a flow cytometer.RESULTS:
The percentage of granulocytes undergoing phagocytosis was 88.4% in the control population. Following exposure to RCM, this value fell to 79.2% with iohexol, 77.6% with iotrolan, 70.5% with diatrizoate, and 68.7% with ioxaglate. The number of bacteria phagocytosed by active leukocytes was not affected by RCM.CONCLUSION:
RCM adversely affect the percentage of granulocytes involved in phagocytosis but not the number of pathogenic bacteria that are phagocytosed by individual granulocytes.
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Base de dados:
MEDLINE
Assunto principal:
Fagocitose
/
Meios de Contraste
/
Leucócitos
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Reino Unido