Familial and hereditary non-polyposis colorectal cancer: issues relevant for surgical practice.
Recent Results Cancer Res
; 146: 20-31, 1998.
Article
em En
| MEDLINE
| ID: mdl-9670246
ABSTRACT
About 15% of patients with colorectal cancer report a family history of this disease. An estimated 1%-5% of patients have hereditary non-polyposis colorectal cancer (HNPCC). Recently, DNA mismatch repair genes associated with this syndrome were identified. For about 50% of families in which HNPCC occurs, DNA-based diagnosis and presymptomatic DNA testing are now feasible. Diagnosis of a hereditary tumour syndrome is relevant for both the patient with cancer and his or her close relatives. The complexities of family studies warrant the forming of a multidisciplinary team which may choose to work within a specialized cancer family clinic.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais Hereditárias sem Polipose
/
Pólipos Adenomatosos
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Holanda