ABSTRACT
This cases series describes the profile of adult patients with acute promyelocytic leukaemia (APt) at a referral hospital in Qatar. Of 34 acute myeloid leukaemia (AML) cases diagnosed, 11(32%) were classified as APt. Disseminated intravascular coagulation was common at presentation (91%). Severe thrombocytopenia was seen in 73%, leukocytosis in 55% and severe anaemia in 45%. Only 2 patients were of the classic hypergranular type. In the remaining 9 patients, 3 morphological subtypes were recognized: microgranular variant (6 patients), hyperbasophilic (2 patients) and regular nuclear outline M3r (1 patient). Translocation t(15;17) was detected in 63% of cases. APL constitutes a high proportion of AML cases in Qatar, with considerable morphological heterogeneity and a oredominance of APL variants with unfavourable oresenting features.
Subject(s)
Leukemia, Promyelocytic, Acute/epidemiology , Leukemia, Promyelocytic, Acute/pathology , Adolescent , Anemia/epidemiology , Anemia/etiology , Bone Marrow Examination , Cancer Care Facilities , Cytogenetic Analysis , Female , Flow Cytometry , Genetic Variation/genetics , Humans , Immunophenotyping , Karyotyping , Leukemia, Promyelocytic, Acute/classification , Leukemia, Promyelocytic, Acute/etiology , Leukocytosis/epidemiology , Leukocytosis/etiology , Male , Middle Aged , Population Surveillance , Qatar/epidemiology , Thrombocytopenia/epidemiology , Thrombocytopenia/etiology , Translocation, Genetic , Young AdultABSTRACT
This cases series describes the profile of adult patients with acute promyelocytic leukaemia [APL] at a referral hospital in Qatar of 34 acute myeloid leukaemia [AML] cases diagnosed, 11 [32%] were classified as APL. Disseminated intravascular coagulation was common at presentation [91%]. Severe thrombocytopenia was seen in 73%, leukocytosis in 55% and severe anaemia in 45%. Only 2 patients were of the classic hypergranular type. In the remaining 9 patients, 3 morphological subtypes were recognized: microgranular variant [6 patients], hyperbasophilic [2 patients] and regular nuclear outline M3r [1 patient]. Translocation t[15;17] was detected in 63% of cases. APL constitutes a high proportion of AML cases in Qatar, with considerable morphological heterogeneity and a predominance of APL variants with unfavourable presenting features