[Radioiodine therapy of thyrotoxicosis in a central hospital]. / Radiojodterapi af tyreotoksikose på et centralsygehus.

The aim of this study was to assess the results of 131-I therapy on hyperthyroidism. 131-I doses were individually calculated on the basis of thyroid gland classification, size and iodine-uptake. All patients were pretreated with propylthiouracil or methimazole. Seventy-nine patients treated with radio-iodine during the period 1.3.81-1.6.88 were followed up. The period of observation was 12-100 months (median 57). After eight years and four months the cumulative incidence of hypothyroidism was 45%, being 69% for diffuse goitre, 31% for multinodular goitre and 24% for solitary adenoma. A Cox-analysis showed a significantly greater cumulative incidence of hypothyroidism in patients with diffuse goitre as opposed to non-diffuse. From our data we conclude that radio-iodine therapy of hyperthyroidism with individually calculated doses of 131-I is a satisfactory method, assuming that patients are subjected to lifelong follow-up.

[Diabetes mellitus and pregnancy. Treatment and results from a central hospital]. / Diabetes mellitus og graviditet. Behandling og resultater fra et centralsygehus.

During the years 1972-1988, 166 pregnant diabetics gave birth to 178 children at Herning Central Hospital. A regimen of meticulous diabetologic and obstetric control was used. The mean duration of pregnancy at delivery was 37 weeks. Induced vaginal delivery was used in 31%, Caesarean section was preferred in 51%. The total perinatal mortality was 3.9%. Among the 171 pregnancies, three developed diabetic precoma, 15 developed preeclampsia and 41 had urinary tract infection. Birth weight over the 90th centile was seen in 15.3%. The frequency of congenital malformations was 2.8%; 1.1% slight and 1.7% severe malformations.