ABSTRACT
Background and aim: Although there are case reports and guideline recommendations that states omalizumab can be used in chronic spontaneous urticaria (CSU) patients during SARS-CoV-2 pandemic, there are scarce studies showing the course of Coronavirus disease 2019 (COVID-19) in CSU patients receiving omalizumab. Materials and methods: A total of 370 patients with chronic urticaria were included in the study between June 2020 and December 31, 2020. Results: Sixty patients (16.2%) became infected with the SARS-CoV-2. The rate of pneumonia and hospitalization were 4.1% and 1.9%. There was no significant difference was determined between the CSU patients with omalizumab treatment and the non-receivers in regard to the rate of SARS-CoV-2 (+) (P: 0.567) and in regard to the rate of SARS-CoV-2 related pneumonia and hospitalization (P: 0.331 and P: 0.690). Gender, duration of CSU, serum IgE levels, omalizumab treatment, and atopy were not found to be associated with an increased risk for SARS-CoV-2 positivity in patients with CSU. Conclusion: Our study shows that the use of omalizumab does not increase the risk of COVID-19 infection, COVID-19-related pneumonia and COVID-19-related hospitalizations in CSU patients.
Introduction: Bien qu'il existe des rapports de cas et des recommandations de lignes directrices indiquant que l'omalizumab peut être utilisé chez les patients atteints d'urticaire spontanée chronique (CSU) pendant la pandémie de SARS-CoV-2, il existe peu d'études montrant l'évolution de la maladie à coronavirus 2019 (COVID-19) chez les patients atteints d'urticaire spontanée recevant de l'omalizumab. Matériaux et méthodes: Un total de 370 patients atteints d'urticaire chronique ont été inclus dans l'étude entre juin 2020 et le 31 décembre 2020. Résultat: Soixante patients (16,2 %) ont été infectés par le SARS-CoV-2. Les taux de pneumonie et d'hospitalisation étaient de 4,1 % et de 1,9 %. Aucune différence significative n'a été déterminée entre les patients atteints de CSU traités par omalizumab et les non-traités en ce qui concerne le taux de SARS-CoV-2 (+) (p : 0,567) et en ce qui concerne le taux de pneumonie et d'hospitalisation liées au SRAS-CoV-2 (p : 0,331 et p : 0,690). Le genre, la durée de la CSU, les taux sériques d'lgE, le traitement par omalizumab et l'atopie n'ont pas été associés à un risque accru de positivité au SRAS-CoV-2 chez les patients atteints de CSU. Conclusion: Notre étude montre que l'utilisation de l'omalizumab n'augmente pas le risque d'infection à la COVID-19, de pneumonie liée à la COVID-19 et d'hospitalisations chez les patients atteints de CSU et soutient l'opinion selon laquelle l'omalizumab peut être utilisé en toute sécurité chez les patients atteints de CSU pendant la pandémie de COVID-19.
ABSTRACT
Introduction: Nonatopic asthmatic patients generally have more severe clinical manifestations, frequently accompanied by chronic sinusitis and nasal polyps, with more limited therapeutic options as compared to atopic asthmatic patients. This has led to a search for novel thera-peutic approaches, including omalizumab, for nonatopic asthmatic patients who are not ade-quately controlled with current therapies.Materials and Methods: In this retrospective study undertaken between August 1, 2020, and December 31, 2021, at a tertiary allergy clinic, data from 61 patients with nonatopic asthma inadequately controlled with optimum therapy was examined.Results: A total of 61 patients with severe asthma were included in the study [Female: 48 (78.7%), male: 13 (21.3%, mean age: 49 (1871) years]. The mean duration of asthma was 60 (18160) months. A statistically significant increase in Forced expiratory volume (FEV1per sec-ond), forced vital capacity (FVC), and asthma control test (ACT) scores were found after 1 year of omalizumab treatment (p < 0.001, for all parameters). Omalizumab treatment was associated with a significant decrease in the number of asthma exacerbations, asthma-related hospitalizations, duration of hospitalizations, and several unplanned emergency room visits after 1 year (p < 0.001, for all parameters). A 1-year treatment with omalizumab led to signif-icant changes in eosinophil counts and serum IgE levels (p < 0.001 and < 0.001, respectively).Conclusion: In the severe atopic asthma patient group, omalizumab treatment provided similar clinical benefits to those observed in patients with severe atopic asthma, suggesting that it may be a useful therapeutic option in patients with nonatopic asthma who failed to benefit from treatments with steps 4 and 5 (AU)