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Dermatol Online J ; 23(1)2017 Jan 15.
Article in English | MEDLINE | ID: mdl-28329473

ABSTRACT

We report a 52-year old woman with a 28-year historyof disfiguring facial discoid lupus erythematosus(DLE), persistent despite both classical therapiesand rituximab. Ustekinumab 45 mg was started incombination with methotrexate and intralesionalcorticosteroids. Methotrexate and intralesionalcorticosteroids were withdrawn 30 months later andustekinumab maintained as monotherapy. Fortyeight months later stable improvement was achievedwithout side effects. Only nine patients with cutaneouslupus erythematosus (CLE) treated with ustekinumabhave been reported to date. Ustekinumab could be apromising alternative in severe and recalcitrant casesof CLE. Possibly, the Th17-inflammation pathway isplaying a role in these patients.


Subject(s)
Dermatologic Agents/therapeutic use , Facial Dermatoses/drug therapy , Lupus Erythematosus, Discoid/drug therapy , Ustekinumab/therapeutic use , Adrenal Cortex Hormones/therapeutic use , Facial Dermatoses/pathology , Female , Humans , Immunologic Factors/therapeutic use , Immunosuppressive Agents/therapeutic use , Injections, Intralesional , Lupus Erythematosus, Discoid/pathology , Methotrexate/therapeutic use , Middle Aged , Rituximab/therapeutic use , Treatment Failure
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