ABSTRACT
INTRODUCTION: There is scant information available in Spain regarding virological markers and clinical status in Sub-Saharan patients infected with HVB. METHODS: A cross-sectional and retrospective study of virological markers and clinical status of HBV infection in 510 adult patients from Sub-Saharan Africa, not co-infected with HIV, most of them from West Africa countries. RESULTS: A total of 90.8% of patients had markers of HBV infection and 137 (26.9%) were HBsAg positive. Among patients with HBsAg positive, 55.9% were chronic inactive carriers. The predominant genotype was E. CONCLUSIONS: The study shows a high prevalence of both markers of HBV infection and of chronic hepatitis B in immigrants from Sub-Saharan Africa.
Subject(s)
Emigrants and Immigrants/statistics & numerical data , Hepatitis B/ethnology , Adolescent , Adult , Africa South of the Sahara/ethnology , Aged , Carcinoma, Hepatocellular/epidemiology , Carcinoma, Hepatocellular/etiology , Carrier State/blood , Carrier State/epidemiology , Carrier State/ethnology , Cross-Sectional Studies , Female , Hepatitis B/blood , Hepatitis B/epidemiology , Hepatitis B Antibodies/blood , Hepatitis B Antigens/blood , Hepatitis B, Chronic/blood , Hepatitis B, Chronic/epidemiology , Hepatitis B, Chronic/ethnology , Humans , Liver Cirrhosis/epidemiology , Liver Cirrhosis/etiology , Liver Neoplasms/epidemiology , Liver Neoplasms/etiology , Male , Middle Aged , Retrospective Studies , Seroepidemiologic Studies , Spain/epidemiology , Young AdultABSTRACT
Laboratory cross-contamination by Mycobacterium tuberculosis is known to be responsible for the misdiagnosis of tuberculosis, but its impact on other contexts has not been analyzed. We present the findings of a molecular epidemiology analysis in which the recent transmission events identified by a genotyping reference center were overestimated as a result of unnoticed laboratory cross-contamination in the original diagnostic laboratories.
Subject(s)
Diagnostic Errors , Equipment Contamination , Molecular Epidemiology , Mycobacterium tuberculosis/classification , Tuberculosis/diagnosis , Tuberculosis/epidemiology , Bacterial Typing Techniques , HumansABSTRACT
Introducción Existen escasos estudios en España sobre la situación virológica y clínica de los pacientes subsaharianos infectados por VHB. Métodos Estudio transversal y retrospectivo de marcadores virológicos y clínico de infección por VHB en 510 pacientes subsaharianos adultos, no infectados por VIH, procedentes en su mayoría del Oeste de África. Resultados El 90,8% presentaba marcadores de infección por VHB. Ciento treinta y siete pacientes (26,9%) presentaban AgHBs+, siendo el 55,9% portadores crónicos inactivos. El genotipo E fue el predominante. Conclusiones El estudio demuestra una elevada prevalencia de marcadores serológicos y sobre todo de infección crónica por VHB en la población inmigrante subsahariana (AU)
Introduction There is scant information available in Spain regarding virological markers and clinical status in Sub-Saharan patients infected with HVB. Methods A cross-sectional and retrospective study of virological markers and clinical status of HBV infection in 510 adult patients from Sub-Saharan Africa, not co-infected with HIV, most of them from West Africa countries .Results A total of 90.8% of patients had markers of HBV infection and 137 (26.9%) were HBsAg positive. Among patients with HBsAg positive, 55.9% were chronic inactive carriers. The predominant genotype was E. Conclusions The study shows a high prevalence of both markers of HBV infection and of chronic hepatitis B in immigrants from Sub-Saharan Africa (AU)