1.
Br J Dermatol
; 181(3): 626-627, 2019 09.
Article
in English
| MEDLINE
| ID: mdl-30828784
Subject(s)
Drug Eruptions/epidemiology , Drug Labeling , Medication Errors/statistics & numerical data , Skin/drug effects , Databases, Factual/statistics & numerical data , Drug Eruptions/etiology , Drug Eruptions/prevention & control , France/epidemiology , Humans , Medication Errors/adverse effects , Medication Errors/prevention & control , Pharmacovigilance , Retrospective Studies
2.
Ann Dermatol Venereol
; 135(2): 131-3, 2008 Feb.
Article
in French
| MEDLINE
| ID: mdl-18342096
ABSTRACT
BACKGROUND: Nicorandil is a potassium-channel activator used to prevent angina. While mucosal ulceration is a well-known adverse effect of this drug, skin ulcers have been described only rarely, and always in association with mucosal ulcers. PATIENTS AND METHODS: An 86-year-old woman presented ulceration on a pacemaker implantation scar despite complete initial wound healing. Nicorandil had been initiated three months earlier. None of the usual causes of ulceration of a pacemaker scar were seen. Complete and permanent wound-healing was achieved 12 days after discontinuation of nicorandil. DISCUSSION: This is the first reported case of cutaneous ulceration on a vulnerable area of skin ascribable to high-dose nicorandil.
Subject(s)
Anti-Arrhythmia Agents/adverse effects , Nicorandil/adverse effects , Pacemaker, Artificial , Skin Ulcer/chemically induced , Aged, 80 and over , Cicatrix/pathology , Conjunctivitis/chemically induced , Female , Follow-Up Studies , Humans
3.
Ann Dermatol Venereol
; 136(4): 364-5, 2009 Apr.
Article
in French
| MEDLINE
| ID: mdl-19361706