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Clin Infect Dis
; 74(10): 1855-1858, 2022 05 30.
Article
in English
| MEDLINE
| ID: mdl-34549268
ABSTRACT
We determined total and unbound concentrations of doravirine (DOR) in cerebrospinal fluid and blood plasma. Total and unbound DOR concentrations in cerebrospinal fluid exceeded the half-maximal effective concentration against wild-type virus (5.1 ng/mL) in all patients, suggesting that DOR may contribute to inhibit viral replication in this compartment.