ABSTRACT
Engineering the building blocks in metal-organic materials is an effective strategy for tuning their dynamical properties and can affect their response to external guest molecules. Tailoring the interaction and diffusion of molecules into these structures is highly important, particularly for applications related to gas separation. Herein, we report a vanadium-based hybrid ultramicroporous material, VOFFIVE-1-Ni, with temperature-dependent dynamical properties and a strong affinity to effectively capture and separate carbon dioxide (CO2) from methane (CH4). VOFFIVE-1-Ni exhibits a CO2 uptake of 12.08 wt % (2.75 mmol g-1), a negligible CH4 uptake at 293 K (0.5 bar), and an excellent CO2-over-CH4 uptake ratio of 2280, far exceeding that of similar materials. The material also exhibits a favorable CO2 enthalpy of adsorption below -50 kJ mol-1, as well as fast CO2 adsorption rates (90% uptake reached within 20 s) that render the hydrolytically stable VOFFIVE-1-Ni a promising sorbent for applications such as biogas upgrading.
ABSTRACT
For the first time, the use of stannate-based sorbents was investigated as high temperature CO2 sorption to evaluate their potential to contribute towards reducing carbon emissions. The sorption capacity and kinetics of commercial tin oxide, sodium, potassium and calcium stannates and lab synthesised potassium stannates were tested using thermogravimetric analysis. Commercial K2SnO3 was found to possess the largest CO2 uptake capacity (2.77 mmol CO2/g or 12.2 wt%) at 700 °C, which is among the highest for potassium sorbents, but the CO2 desorption was not successful. On the contrary, the in-house synthesised K-stannate (K-B) using facile solid-state synthesis outperformed the other sorbents, resulting in a CO2 uptake of 7.3 wt% after 5 min, an adsorption rate (0.016 mg/s) one order of magnitude higher than the other stannates, and stability after 40 cycles. The XRD and XPS analyses showed that K-B contains a mixture of K2SnO3 (76%) and K4SnO4 (21%), while the Scherrer crystal sizes confirmed good resistance to sintering for the potassium stannates. Among the apparent kinetic model tested, the pseudo-second order model was the most suitable to predict the CO2 sorption process of K-B, indicating that chemical adsorption is dominant, while film-diffusion resistance and intra-particle diffusion resistance governed the sorption process in K-B. In summary, this work shows that solid-state synthesised potassium stannate could be an effective sorbent for high temperature separation, and additional work is required to further elucidate its potential.
Subject(s)
Carbon Dioxide , Potassium , Carbon Dioxide/chemistry , Temperature , Kinetics , Hot Temperature , AdsorptionABSTRACT
A metal-organic framework (MOF) CTH-17 based on lanthanum(III) and the conformationally chiral linker 1,2,3,4,5,6-hexakis(4-carboxyphenyl)benzene, cpb6-: [La2(cpb)]·1.5dmf was prepared by the solvothermal method in dimethylformamide (dmf) and characterized by variable-temperature X-ray powder diffraction (VTPXRD), variable-temperature X-ray single-crystal diffraction (SCXRD), and thermogravimetric analysis (TGA). CTH-17 is a rod-MOF with new topology och. It has high-temperature stability with Sohncke space groups P6122/P6522 at 90 K and P622 at 300 and 500 K, all phases characterized with SCXRD and at 293 K also with three-dimensional (3D) electron diffraction. VTPXRD indicates a third phase appearing after 620 K and stable up to 770 K. Gas sorption isotherms with N2 indicate a modest surface area of 231 m2 g-1 for CTH-17, roughly in agreement with the crystal structure. Carbon dioxide sorption reveals a gate-opening effect of CTH-17 where the structure opens up when the loading of CO2 reaches approximately â¼0.45 mmol g-1 or 1 molecule per unit cell. Based on the SCXRD data, this is interpreted as flexibility based on the concerted movements of the propeller-like hexatopic cpb linkers, the movement intramolecularly transmitted by the π-π stacking of the cpb linkers and helped by the fluidity of the LaO6 coordination sphere. This was corroborated by density functional theory (DFT) calculations yielding the chiral phase (P622) as the energy minimum and a completely racemic phase (P6/mmm), with symmetric cpb linkers representing a saddle point in a racemization process.
ABSTRACT
An attractive approach to increase the aqueous apparent solubility of poorly soluble drugs is to formulate them in their amorphous state. In the present study, celecoxib, a poorly soluble drug, was successfully loaded into mesoporous magnesium carbonate (MMC) in its amorphous state via a solvent evaporation method. Crystallization of celecoxib was suppressed, and no reaction with the carrier was detected. The MMC formulation was evaluated in vitro and in vivo in terms of oral bioavailability. Celebra®, a commercially available formulation, was used as a reference. The two celecoxib formulations were orally administrated in male rats (average of n = 6 animals per group), and blood samples for plasma were taken from all animals at different time points after administration. There was no statistical difference (p > 0.05) in AUCinf between the two formulations. The results showed that MMC may be a promising drug delivery excipient for increasing the bioavailability of compounds with solubility-limited absorption.
Subject(s)
Excipients , Administration, Oral , Animals , Biological Availability , Celecoxib/chemistry , Magnesium , Male , Rats , Solubility , Solvents/chemistryABSTRACT
Nine metal-organic frameworks have been prepared with the hexagon-shaped linker 1,2,3,4,5,6-hexakis(4-carboxyphenyl)benzene (H6cpb) by solvothermal reactions in dimethylformamide (dmf) or dimethylacetamide (dmac) with acetic acid or formic acid as modulators: [Bi2(cpb)(acetato)2(dmf)2]·2dmf CTH-6 forms a rtl-net; 2(H2NMe2)[Cu2(cpb)] CTH-7 forms a kgd-net; [Fe4(cpb)(acetato)2(dmf)4] CTH-8 and [Co4(cpb)(acetato)2(dmf)4] CTH-9 are isostructural and form yav-nets; 2(HNEt3)[Fe2(cpb)] CTH-10 and the two polymorphs of 2(H2NMe2)[Zn2(cpb)]·1.5dmac, Zn-MOF-888 and CTH-11, show kgd-nets; [Cu2(cpb)(acetato)2(dmf)2]·2dmf, CTH-12, forms a mixed coordination and hydrogen-bonded sql-net; and 2(H2NMe2)[Zn2(cpb)] CTH-13, a similarly mixed yav-net. Surface area values (Brunauer-Emmett-Teller, BET) range from 34 m2 g-1 for CTH-12 to 303 m2 g-1 for CTH-9 for samples activated at 120 °C in dynamic vacuum. All compounds show normal (10-fold higher) molar CO2 versus N2 uptake at 298 K, except the 19-fold CO2 uptake for CTH-12 containing Cu(II) dinuclear paddle-wheels. We also show how perfect hexagons and triangles can combine to a new 3D topology laf, a model of which gave us the idea of foldable network topologies, as the laf-net can fold into a 2D form while retaining the local geometry around each vertex. Other foldable nets identified are cds, cds-a, ths, sqc163, clh, jem, and tfc covering the basic polygons and their combinations. The impact of this concept on "breathing" MOFs is discussed. I2 sorption, both from gas phase and from MeOH solution, into CTH-7 were studied by time of flight secondary ion mass spectrometry (ToF-SIMS) on dried crystals. I2 was shown to have penetrated the crystals, as layers were consecutively peeled off by the ion beam. We suggest ToF-SIMS to be a method for studying sorption depth profiles of MOFs.
ABSTRACT
The development of multifunctional heterogeneous catalysts with high porosity and remarkable catalytic activity still remains a challenge. Herein, four highly porous metalloporphyrin covalent ionic frameworks (CIFs) were synthesized by coupling 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin (TNPP) with 3,8-diamino-6-phenylphenanithridine (NPPN) or 5,5'-diamino-2,2'-bipyridine (NBPy) followed by ionization with bromoethane (C2 H5 Br) or dibromoethane (C2 H4 Br2 ) and then metalization with Zn or Co. The resulting CIFs showed high efficiency in catalyzing the cycloaddition of propylene oxide (PO) with CO2 to form propylene carbonate (PC). All of the Zn-containing CIF catalysts were able to catalyze the cycloaddition reaction with a PC yield greater than 97 %. The TNPP/NBPy (CIF2) catalyst ionized with C2 H4 Br2 and metalized with Zn (Zn-CIF2-C2 H4 ) exhibited the highest catalytic activity among the synthesized catalysts. The high catalytic performance of Zn-CIF2-C2 H4 is related to its high porosity (577â m2 g-1 ), high Br:metal ratio (1:3.89), and excellent synergistic action between the Lewis acidic Zn sites and the nucleophilic Br- ions. Zn-CIF2-C2 H4 is sufficiently stable that greater than 94 % PC yield could be obtained even after six cycles. In addition, Zn-CIF2-C2 H4 could catalyze the cycloaddition of several other epoxides with CO2 . These highly porous materials are promising multifunctional and efficient catalysts for industrially relevant reactions.
ABSTRACT
Salicylic acid (SA) has for a long time been used to treat various skin disorders due to its anti-inflammatory, bacteriostatic, and antifungal properties. In the present work, mesoporous magnesium carbonate (MMC), a promising drug carrier, was modified with 3-aminopropyl-triethoxysilane to enable loading of SA. The amine modified MMC (aMMC) was successfully loaded with 8 wt.% of SA via a solvent evaporation method. SA was later completely released from the carrier in less than 15 min. Furthermore, the cytotoxicity of the functionalized material was evaluated. aMMC was found to be non-toxic for human dermal fibroblast cells with particle concentration of up to 1000 µg/mL when exposed for 48 h. The presented results form the basis of future development of aMMC as a potential carrier for SA in dermatological applications.
Subject(s)
Amines/chemistry , Drug Carriers/chemistry , Magnesium/chemistry , Salicylic Acid/pharmacology , Administration, Topical , Cell Line , Cell Survival/drug effects , Drug Compounding , Drug Delivery Systems/methods , Drug Liberation , Humans , Microscopy, Electron, Scanning , Porosity , Salicylic Acid/administration & dosage , Spectroscopy, Fourier Transform InfraredABSTRACT
Effective and compound-sparing methods to evaluate promising drug delivery systems are a prerequisite for successful selection of formulations in early development stages. The aim of the study was to develop a small-scale in situ method to determine drug release and supersaturation in highly concentrated suspensions of enabling formulations. Mesoporous magnesium carbonate (MMC), which delivers the drug in an amorphous form, was selected as a drug carrier. Five model compounds were loaded into the MMC at a 1:10 ratio using a solvent evaporation technique. The µDiss Profiler was used to study the drug release from MMC in fasted-state simulated intestinal fluid. To avoid extensive light scattering previously seen in particle-rich suspensions in the µDiss Profiler, an in-house-designed protective nylon filter was placed on the in situ UV probes. Three types of release experiments were conducted for each compound: micronized crystalline drug with MMC present, drug-loaded MMC, and drug-loaded MMC with 0.01% w/w hydroxypropyl methyl cellulose. The nylon filters effectively diminished interference with the UV absorption; however, the release profiles obtained were heavily compound dependent. For one of the compounds, changes in the UV spectra were detected during the release from the MMC, and these were consistent with degradation of the compound. To conclude, the addition of protective nylon filters to the probes of the µDiss Profiler is a useful contribution to the method, making evaluations of particle-rich suspensions feasible. The method is a valuable addition to the current ones, allowing for fast and effective evaluation of advanced drug delivery systems.
Subject(s)
Drug Carriers/chemistry , Drug Carriers/pharmacokinetics , Hypromellose Derivatives/chemistry , Hypromellose Derivatives/pharmacokinetics , Magnesium/chemistry , Magnesium/pharmacokinetics , Drug Compounding/methods , Drug Delivery Systems/methods , Drug Liberation , Solubility , Solvents , SuspensionsABSTRACT
The|Na10.2KCs0.8|8[Al12Si12O48]8(Fm3[combining macron]c)-LTA zeolite adsorbs CO2-over-CH4 with a high selectivity (over 1500). The uptake of carbon dioxide is also high (3.31 mmol g(-1), 293 K, 101 kPa). This form of zeolite A is a very promising adsorbent for applications such as biogas upgrading, where keeping the adsorption of methane to a minimum is crucial.
ABSTRACT
Adsorbents with high capacity and selectivity for adsorption of CO2 are currently being investigated for applications in adsorption-driven separation of CO2 from flue gas. An adsorbent with a particularly high CO2-over-N2 selectivity and high capacity was tested here. Zeolite ZK-4 (Si:Al â¼ 1.3:1), which had the same structure as zeolite A (LTA), showed a high CO2 capacity of 4.85 mmol/g (273 K, 101 kPa) in its Na(+) form. When approximately 26 at. % of the extraframework cations were exchanged for K(+) (NaK-ZK-4), the material still adsorbed a large amount of CO2 (4.35 mmol/g, 273 K, 101 kPa), but the N2 uptake became negligible (<0.03 mmol/g, 273 K, 101 kPa). The majority of the CO2 was physisorbed on zeolite ZK-4 as quantified by consecutive volumetric adsorption measurements. The rate of physisorption of CO2 was fast, even for the highly selective sample. The molecular details of the sorption of CO2 were revealed as well. Computer modeling (Monte Carlo, molecular dynamics simulations, and quantum chemical calculations) allowed us to partly predict the behavior of fully K(+) exchanged zeolite K-ZK-4 upon adsorption of CO2 and N2 for Si:Al ratios up to 4:1. Zeolite K-ZK-4 with Si:Al ratios below 2.5:1 restricted the diffusion of CO2 and N2 across the cages. These simulations could not probe the delicate details of the molecular sieving of CO2 over N2. Still, this study indicates that zeolites NaK-ZK-4 and K-ZK-4 could be appealing adsorbents with high CO2 uptake (â¼4 mmol/g, 101 kPa, 273 K) and a kinetically enhanced CO2-over-N2 selectivity.
ABSTRACT
The ever-increasing atmospheric CO2 level is considered to be the major cause of climate change. Although the move away from fossil fuel-based energy generation to sustainable energy sources would significantly reduce the release of CO2 into the atmosphere, it will most probably take time to be fully implemented on a global scale. On the other hand, capturing CO2 from emission sources or directly from the atmosphere are robust approaches that can reduce the atmospheric CO2 concentration in a relatively short time. Here, we provide a perspective on the recent development of metal-organic framework (MOF)-based solid sorbents that have been investigated for application in CO2 capture from low-concentration (<10 000 ppm) CO2 sources. We summarized the different sorbent engineering approaches adopted by researchers, both from the sorbent development and processing viewpoints. We also discuss the immediate challenges of using MOF-based CO2 sorbents for low-concentration CO2 capture. MOF-based materials, with tuneable pore properties and tailorable surface chemistry, and ease of handling, certainly deserve continued development into low-cost, efficient CO2 sorbents for low-concentration CO2 capture.
ABSTRACT
A manganese(II) metal-organic framework based on the hexatopic hexakis(4-carboxyphenyl)benzene, cpb6-: [Mn3(cpb)(dmf)3], was solvothermally prepared showing a Langmuir area of 438 m2 g-1, rapid uptake OF sulfur hexafluoride (SF6) as well as electrochemical and magnetic properties, while single crystal diffraction reveals an unusual rod-MOF topology.
ABSTRACT
Nanomedicine plays a crucial role in the development of next-generation therapies. The use of nanoparticles as drug delivery platforms has become a major area of research in nanotechnology. To be effective, these nanoparticles must interact with desired drug molecules and release them at targeted sites. The design of these "nanoplatforms" typically includes a functional core, an organic coating with functional groups for drug binding, and the drugs or bioactive molecules themselves. However, by exploiting the coordination chemistry between organic molecules and transition metal centers, the self-assembly of drugs onto the nanoplatform surfaces can bypass the need for an organic coating, simplifying the materials synthesis process. In this perspective, we use gold-iron oxide nanoplatforms as examples and outline the prospects and challenges of using self-assembly to prepare drug-nanoparticle constructs. Through a case study on the binding of insulin on Au-dotted Fe3O4 nanoparticles, we demonstrate how a self-assembly system can be developed. This method can also be adapted to other combinations of transition metals, with the potential for scaling up. Furthermore, the self-assembly method can also be considered as a greener alternative to traditional methods, reducing the use of chemicals and solvents. In light of the current climate of environmental awareness, this shift towards sustainability in the pharmaceutical industry would be welcomed.
ABSTRACT
The use of PPE has drastically increased because of the SARS-CoV-2 (COVID-19) pandemic as disposable surgical face masks made from non-biodegradable polypropylene (PP) polymers have generated a significant amount of waste. In this work, a low-power plasma method has been used to degrade surgical masks. Several analytical techniques (gravimetric analysis, scanning electron microscopy (SEM), attenuated total reflection-infra-red spectroscopy (ATR-IR), x-ray photoelectron spectroscopy (XPS), thermogravimetric analysis/differential scanning calorimetry (TGA/DSC) and wide-angle x-ray scattering (WAXS)) were used to evaluate the effects of plasma irradiation on mask samples. After 4 h of irradiation, an overall mass loss of 63 ± 8%, through oxidation followed by fragmentation, was observed on the non-woven 3-ply surgical mask, which is 20 times faster than degrading a bulk PP sample. Individual components of the mask also showed different degradation rates. Air plasma clearly represents an energy-efficient tool for treating contaminated PPE in an environmentally friendly approach.
ABSTRACT
Alkyl and alkoxy phenols are desirable products from the catalytic depolymerisation of lignin. In this work, ex-situ catalytic pyrolysis of Etek lignin in presence of Na, Ce, NiCe, MgCe, Fe and FePd on ZrO2 was studied. The largest combined yield of monomeric phenolics and alkylphenols was produced by Na/ZrO2 catalysts. A parametric study of the most promising Na/ZrO2 then resulted in using a catalyst:lignin ratio of 3:1 at 500 °C as the best option, enhancing at 17.5 wt% the recovery of total phenolics including 6 wt% alkyl phenols, which is equivalent to 27.8 wt% and 9.5 wt% of the starting lignin in Etek lignin waste. The study of the catalyst basicity indicates that the mild basicity of Na/ZrO2 was mostly responsible for the enhanced mono phenols recovery. Due to formation of thermally stable Na2CO3 during pyrolysis, successful Na/ZrO2 regeneration requires temperature of 900 °C or higher.
Subject(s)
Lignin , Phenols , Alcohols , Catalysis , Oxides , ZirconiumABSTRACT
Advanced drug delivery systems (ADDS) are widely explored to overcome poor aqueous solubility of orally administered drugs. However, the prediction of their in vivo performance is challenging, as in vitro models typically do not capture the interplay between processes occurring in the gut. In additions, different models are used to evaluate the different systems. We therefore present a method that allows monitoring of luminal processing (dissolution, digestion) and its interplay with permeation to better inform on the absorption of felodipine formulated as ADDS. Experiments were performed in a µFLUX-apparatus, consisting of two chambers, representing the intestinal and serosal compartment, separated by Caco-2 monolayers. During dissolution-digestion-permeation experiments, ADDS were added to the donor compartment containing simulated intestinal fluid and immobilized lipase. Dissolution and permeation in both compartments were monitored using in situ UV-probes or, when turbidity interfered the measurements, with HPLC analysis. The method showed that all ADDS increased donor and receiver concentrations compared to the condition using crystalline felodipine. A poor correlation between the compartments indicated the need for an serosal compartment to evaluate drug absorption from ADDS. The method enables medium-throughput assessment of: (i) dynamic processes occurring in the small intestine, and (ii) drug concentrations in real-time.
Subject(s)
Chemistry, Pharmaceutical , Drug Delivery Systems , Felodipine/administration & dosage , Intestinal Absorption , Administration, Oral , Caco-2 Cells , Crystallization , Felodipine/chemistry , Felodipine/pharmacokinetics , Humans , SolubilityABSTRACT
Zeolites with appropriately narrow pore apertures can kinetically enhance the selective adsorption of CO2 over N2. Here, we showed that the exchangeable cations (e.g., Na+ or K+) on zeolite ZK-4 play an important role in the CO2 selectivity. Zeolites NaK ZK-4 with Si/Al = 1.8-2.8 had very high CO2 selectivity when an intermediate number of the exchangeable cations were K+ (the rest being Na+). Zeolites NaK ZK-4 with Si/Al = 1.8 had high CO2 uptake capacity and very high CO2-over-N2 selectivity (1190). Zeolite NaK ZK-4 with Si/Al = 2.3 and 2.8 also had enhanced CO2 selectivity with an intermediate number of K+ cations. The high CO2 selectivity was related to the K+ cation in the 8-rings of the α-cage, together with Na+ cations in the 6-ring, obstructing the diffusion of N2 throughout the zeolite. The positions of the K+ cation in the 8-ring moved slightly (max 0.2 Å) toward the center of the α-cage upon the adsorption of CO2, as revealed by in situ X-ray diffraction. The CO2-over-N2 selectivity was somewhat reduced when the number of K+ cations approached 100%. This was possibly due to the shift in the K+ cation positions in the 8-ring when the number of Na+ was going toward 0%, allowing N2 diffusion through the 8-ring. According to in situ infrared spectroscopy, the amount of chemisorbed CO2 was reduced on zeolite ZK-4s with increasing Si/Al ratio. In the context of potential applications, a kinetically enhanced selection of CO2 could be relevant for applications in carbon capture and bio- and natural gas upgrading.
ABSTRACT
Lipid-based formulations can circumvent the low aqueous solubility of problematic drug compounds and increase their oral absorption. As these formulations are often physically unstable and costly to manufacture, solidification has been suggested as a way to minimize these issues. This study evaluated the physicochemical stability and in vitro performance of lipid-loaded mesoporous magnesium carbonate (MMC) particles with an average pore size of 20 nm. A medium chain lipid was loaded onto the MMC carrier via physical adsorption. A modified in vitro lipolysis setup was then used to study lipid release and digestion with 1H nuclear magnetic resonance spectroscopy. The lipid loading efficiency with different solidification techniques was also evaluated. The MMC, unlike more commonly used porous silicate carriers, dissolved during the lipolysis assay, providing a rapid release of encapsulated lipids into solution. The digestion of the dispersed lipid-loaded MMC therefore resembled that of a coarse dispersion of the lipid. The stability data demonstrated minor degradation of the lipid within the pores of the MMC particles, but storage for three months did not reveal extensive degradation. To conclude, lipids can be adsorbed onto MMC, creating a solid powder from which the lipid is readily released into the solution during in vitro digestion. The chemical stability of the formulation does however merit further attention.
ABSTRACT
Highly porous, strong aerogels with anisotropic structural properties are of great interest for multifunctional materials for applications including insulators in buildings, filters for oil cleanup, electrical storage devices, etc. Contemporary aerogels are mostly extracted from fossil resources and synthesized from bottom-up techniques, often requiring additional strategies to obtain high anisotropy. In this work, a universal approach to prepare porous, strong, anisotropic aerogels is presented through exploiting the natural hierarchical and anisotropic structure of wood. The preparation comprises nanoscale removal of lignin, followed by dissolution-regeneration of nanofibers, leading to enhanced cell wall porosity with nanofibrillated networks occupying the pore space in the cellular wood structure. The aerogels retain structural anisotropy of natural wood, exhibit specific surface areas up to 247 m2/g, and show high compression strength at 95% porosity. This is a record specific area value for wood aerogels/foams and even higher than most cellulose-based aerogels for its assigned strength. The aerogel can serve as a platform for multifunctional composites including scaffolds for catalysis, gas separation, or liquid purification due to its porous matrix or as binder-free electrodes in electronics. To demonstrate the multifunctionality, the aerogels are successfully decorated with metal nanoparticles (Ag) and metal oxide nanoparticles (TiO2) by in situ synthesis, coated by the conductive polymer (PEDOT:PSS), and carbonized to yield conductive aerogels. This approach is found to be a universal way to prepare highly porous anisotropic aerogels.
ABSTRACT
A calcium magnesium carbonate composite (CMC) material containing highly porous amorphous calcium carbonate (HPACC) and mesoporous magnesium carbonate (MMC) was synthesized. CMCs with varying HPACC : MMC mol ratios and high BET surface area (over 490 m2 g-1) were produced. The CMCs retained the morphology shared by HPACC and MMC. All these materials were built up of aggregated nanometer-sized particles. We tested the CO2 uptake properties of the synthesized materials. The CMCs were calcined at 850 °C to obtain the corresponding calcium magnesium oxide composites (CMOs) that contained CaO : MgO at different mol ratios. CMO with CaO : MgO = 3 : 1 (CMO-3) showed comparable CO2 uptake at 650 °C (0.586 g g-1) to CaO sorbents obtained from pure HPACC (0.658 g g-1) and the commercial CaCO3 (0.562 g g-1). Over 23 adsorption-desorption cycles CMOs also showed a lower CO2 uptake capacity loss (35.7%) than CaO from HPACC (51.3%) and commercial CaCO3 (79.7%). Al was introduced to CMO by the addition of Al(NO3)3 in the synthesis of CMC-3 to give ACMO after calcination. The presence of â¼19 mol% of Al(NO3)3 in ACMO-4 significantly enhanced its stability over 23 cycles (capacity loss of 5.2%) when compared with CMO-3 (calcined CMC-3) without adversely affecting the CO2 uptake. After 100 cycles, ACMO-4 still had a CO2 uptake of 0.219 g g-1. Scanning electron microscope images clearly showed that the presence of Mg and Al in CMO hindered the sintering of CaCO3 at high temperatures and therefore, enhanced the cycle stability of the CMO sorbents. We tested the CO2 uptake properties of CMO and ACMO only under ideal laboratory testing environment, but our results indicated that these materials can be further optimized as good CO2 sorbents for various applications.