ABSTRACT
137 cases of unfavourable outcome in IUD insertion (i.e. early removal or expulsion because of complications) were investigated as regards age, parity, previous intrauterine contraception, previous induced abortion, type of device inserted, and type of complications observed. Moreover, this group was compared for each feature mentioned with a control group of 454 women who successfully concluded the prescribed period from the insertion. All the devices were inserted with a significantly higher rate of favourable outcome in pluriparous versus nulliparous patients; age probably didn't affect the outcome, but strongly conditioned the prevalence of particular complications such as PID and abnormal bleeding. Progesterone-loaded IUD didn't show a more favourable outcome than copper devices.
PIP: The factors associated with 137 cases of IUD expulsion or early removal due to complications were investigated in a case-control study conducted at an Italian family planning clinic. The 454 controls were women who did not experience adverse IUD outcomes. Complications in the study group included: bleeding (35%), expulsion (13%), pregnancy (13%), pelvic pain (15%), and pelvic inflammatory disease (24%). The majority of complications occurred 6-12 months after IUD insertion. Previous IUD use and the type of IUD inserted were unrelated to outcome. Most significant in terms of outcome was parity. There was a statistically significant (p .001) difference between the percentage of nulliparae in the study group (34%) compared with the control group (17%). Although most of the nulliparae in the study group were under 20 years of age, age did not have a significant correlation with IUD outcome. Pelvic inflammatory disease was significantly more prevalent in women under 30 years of age, while excessive bleeding was more common in cases above this age.
Subject(s)
Intrauterine Devices/adverse effects , Adult , Age Factors , Aged , Humans , Middle AgedABSTRACT
This case report demonstrates the interface histology of hydroxyapatite-coated dental implants placed in a human vascularized iliac bone graft. Microscopic evaluation found a direct contact of lamellar bone to the implant surface even in areas of loose trabeculation. The hydroxyapatite coating was intact, with no evidence of resorption. This study appears to show that the healing response to hydroxyapatite-coated implants placed in vascularized bone grafts is similar to previously reported findings in nongrafted sites.
Subject(s)
Bone Transplantation , Dental Implantation, Endosseous , Dental Implants , Durapatite , Mandible/surgery , Aged , Bone Transplantation/methods , Bone Transplantation/pathology , Durapatite/chemistry , Humans , Ilium , Male , Mandible/pathology , Mandibular Diseases/surgery , Odontogenic Cysts/surgery , Osseointegration , Surface Properties , Wound HealingABSTRACT
The authors report the preliminary results of an experience of treatment with clarythromycin in Chlamydia trachomatis endocervicitis/endourethritis; 100% of 51 outpatients treated had negative ELISA results 7-10 days after the end of treatment with clarythromycin 500 mg. b.i.d. for 7 days. Among 64 female outpatients with chlamydial cervicitis treated with erythromycin 1 g b.i.d. for 7 days, 88% were negative at ELISA at the same intervals after therapy. The authors conclude that the efficacy of clarythromycin in this experience makes it use worthy of other and more extensive studies.
Subject(s)
Chlamydia Infections/drug therapy , Clarithromycin/therapeutic use , Genital Diseases, Female/drug therapy , Genital Diseases, Male/drug therapy , Adult , Chlamydia Infections/microbiology , Enzyme-Linked Immunosorbent Assay , Female , Genital Diseases, Female/microbiology , Genital Diseases, Male/microbiology , Humans , Male , Middle Aged , Urethritis/drug therapy , Urethritis/microbiology , Uterine Cervicitis/drug therapy , Uterine Cervicitis/microbiologyABSTRACT
Apelin is an endogenous ligand of the human orphan receptor APJ. This peptide is produced through processing from the C-terminal portion in the pre-pro-protein consisting of 77 amino acid residues and exists in multiple molecular forms. Although the main physiological functions of apelin have not yet been clarified, it is known that apelin is involved in the regulation of blood pressure, blood flow and central control of body fluid homeostasis in different organs. Since human placenta is a tissue where vasculogenesis, blood pressure and flow are dramatically important to allow a normal embryonic and fetal growth and development, the aim of the present study was to investigate the immunohistochemical distribution of apelin and APJ in normal placentas throughout pregnancy and in preeclampsia-complicated placentas. Specifically, we observed that in normal placentas the expression levels of apelin decreased from the first to the third trimester of gestation in both cytotrophoblast and syncytiotrophoblast cells and in the stroma of placental villi, in contrast with increased expression levels of APJ in the cytoplasm of cytotrophoblast cells and in the cytoplasm of endothelial cells of normal placenta samples. In contrast, in preeclampsia-complicated pregnancies, we observed a very strong increase of expression levels of both apelin and APJ receptor in all the placental compartments, cytotrophoblast, syncytiotrophoblast and stroma with a particular increase in endothelial cells inside preeclamptic placental villi. Our data seem to indicate an important role of apelin and APJ in the regulation of fetal development through a correct regulation of human placenta formation during pregnancy. Moreover, the strong expression levels of apelin and APJ in preeclamptic placentas, suggest their possible involvement in the onset of this pathology.
Subject(s)
Gene Expression Regulation , Intercellular Signaling Peptides and Proteins/biosynthesis , Placenta/metabolism , Pre-Eclampsia/metabolism , Pregnancy Complications, Cardiovascular , Receptors, G-Protein-Coupled/biosynthesis , Adult , Apelin , Apelin Receptors , Female , Humans , Immunohistochemistry , Ligands , PregnancyABSTRACT
The reconstruction of cranial vault deformities resulting from trauma presents many challenges. The need to provide good esthetic contour as well as protection for underlying neural structures is paramount. We present two cases of craniorbital defects successfully treated using three-dimensional computer-generated models to fabricate surgical prostheses. The use of these models provided excellent esthetic and functional results with minimal blood loss, relatively short operating time, and less exposure of the patient to the complication of prolonged anesthesia.
Subject(s)
Prostheses and Implants , Skull/injuries , Skull/surgery , Adult , Computer Simulation , Female , Humans , Male , Models, StructuralABSTRACT
Numerous surgical procedures have been proposed for the correction of the skeletal open-bite deformity. Mandibular ramus procedures have not been uniformly successful due to the amount of observed relapse in both the horizontal and vertical dimensions. The authors studied 20 patients who underwent correction of an open-bite deformity using the inverted L ramus osteotomy technique. Results indicated that this procedure may have more stability in both the horizontal and vertical dimensions than previously reported ramus procedures.