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1.
Opt Express ; 17(14): 11652-64, 2009 Jul 06.
Article in English | MEDLINE | ID: mdl-19582080

ABSTRACT

High-contrast adaptive optics systems, such as those needed to image extrasolar planets, are known to require excellent wavefront control and diffraction suppression. The Laboratory for Adaptive Optics at UC Santa Cruz is investigating limits to high-contrast imaging in support of the Gemini Planet Imager (GPI). In this paper we examine the effect of heat sources in the testbed on point-spread-function (PSF) stability. Introducing a heat source primarily introduces image motion. The GPI error budget requires image motion to be less than 0.1 lambda /D. Systematic motion of the PSF core is typically 0.01 lambda /D rms and with a 20 watt heat source introduced near the pupil plane image motion is increased to 0.02 lambda /D rms. Therefore, even a heat source as large as 20 watts near the pupil plane causes errors below the GPI requirement, but the combination of the heat source and additional air turbulence on the system introduced by changes to the enclosure or the fan of other components can produce significantly more motion. Heat also can affect the speckle pattern in the high-contrast region, but in the final instrument other sources of error should be more significant.


Subject(s)
Optics and Photonics , Air , Algorithms , Equipment Design , Hot Temperature , Image Processing, Computer-Assisted/methods , Optical Devices
2.
Opt Express ; 17(5): 4084-94, 2009 Mar 02.
Article in English | MEDLINE | ID: mdl-19259248

ABSTRACT

Ultrahigh-resolution adaptive optics-optical coherence tomography (UHR-AO-OCT) instrumentation allowing monochromatic and chromatic aberration correction was used for volumetric in vivo retinal imaging of various retinal structures including the macula and optic nerve head (ONH). Novel visualization methods that simplify AO-OCT data viewing are presented, and include co-registration of AO-OCT volumes with fundus photography and stitching of multiple AO-OCT sub-volumes to create a large field of view (FOV) high-resolution volume. Additionally, we explored the utility of Interactive Science Publishing by linking all presented AO-OCT datasets with the OSA ISP software.


Subject(s)
Retina/anatomy & histology , Tomography, Optical Coherence/methods , Databases, Factual , Fourier Analysis , Fundus Oculi , Humans , Middle Aged , Optical Phenomena , Software Design , Tomography, Optical Coherence/instrumentation , Tomography, Optical Coherence/statistics & numerical data
3.
Opt Express ; 17(16): 13768-84, 2009 Aug 03.
Article in English | MEDLINE | ID: mdl-19654784

ABSTRACT

The combination of adaptive optics (AO) technology with optical coherence tomography (OCT) instrumentation for imaging the retina has proven to be a valuable tool for clinicians and researchers in understanding the healthy and diseased eye. The micrometer-isotropic resolution achieved by such a system allows imaging of the retina at a cellular level, however imaging of some cell types remains elusive. Improvement in contrast rather than resolution is needed and can be achieved through better AO correction of wavefront aberration. A common tool for assessing and ultimately improving AO system performance is the development of an error budget. Specifically, this is a list of the magnitude of the constituent residual errors of an optical system so that resources can be directed towards efficient performance improvement. Here we present an error budget developed for the UC Davis AO-OCT instrument indicating that bandwidth and controller errors are the limiting errors of our AO system, which should be corrected first to improve performance. We also discuss the scaling of error sources for different subjects and the need to improve the robustness of the system by addressing subject variability.


Subject(s)
Algorithms , Image Interpretation, Computer-Assisted/methods , Lenses , Optical Devices , Tomography, Optical Coherence/instrumentation , Computer Simulation , Computer-Aided Design , Equipment Design , Equipment Failure Analysis , Light , Models, Theoretical , Scattering, Radiation
4.
Appl Opt ; 48(21): 4077-89, 2009 Jul 20.
Article in English | MEDLINE | ID: mdl-19623221

ABSTRACT

High-contrast imaging techniques such as coronagraphy are expected to play an important role in the imaging of extrasolar planets. Instruments like the Gemini Planet Imager (GPI) or the Spectro-Polar-Imetric High-Contrast Exoplanet Research (SPHERE) require high-dynamic range, achieved using coronagraphs to block light coming from the parent star. An extremely good adaptive optics (AO) system is required to reduce dynamic atmospheric wavefront errors to 50-100 nm rms. Systematic wavefront errors must also be controlled at the nanometer-equivalent level to remove persistent speckle artifacts. While precision AO systems can control wavefront phase errors at this level, systematic amplitude or intensity errors can also produce speckle artifacts and are uncontrolled by traditional AO phase conjugation. On the Laboratory for Adaptive Optics (LAO) extreme AO testbed, we observed a discrepancy between the coronagraphic image profile and the profile predicted by simple simulations using the measured optical phase, which could potentially be explained by amplitude variations. Measurements showed up to 7% rms intensity changes across the microelectrical mechanical (MEM) plane of the system. We identified potential sources of amplitude variation and compared them to a Fresnel model of the system. One potential concern was the surface structure of the MEM system's (MEMS) deformable mirror, but analysis shows that it induces at most 2% rms variation. The bulk of the observed intensity variation is due to nonuniform illumination of the system by the input single-mode fiber and phase errors mixing into amplitude at the nonpupil-plane due to the Talbot effect, coupled with residual astigmatism in the pupil imager.

5.
J Vis ; 9(2): 24.1-16, 2009 Feb 27.
Article in English | MEDLINE | ID: mdl-19271934

ABSTRACT

The contributions of optical and neural factors to age-related losses in spatial vision are not fully understood. We used closed-loop adaptive optics to test the visual benefit of correcting monochromatic high-order aberrations (HOAs) on spatial vision for observers ranging in age from 18 to 81 years. Contrast sensitivity was measured monocularly using a two-alternative forced-choice (2AFC) procedure for sinusoidal gratings over 6 mm and 3 mm pupil diameters. Visual acuity was measured using a spatial 4AFC procedure. Over a 6 mm pupil, young observers showed a large benefit of AO at high spatial frequencies, whereas older observers exhibited the greatest benefit at middle spatial frequencies, plus a significantly larger increase in visual acuity. When age-related miosis is controlled, young and old observers exhibited a similar benefit of AO for spatial vision. An increase in HOAs cannot account for the complete senescent decline in spatial vision. These results may indicate a larger role of additional optical factors when the impact of HOAs is removed, but also lend support for the importance of neural factors in age-related changes in spatial vision.


Subject(s)
Aging/psychology , Refraction, Ocular , Refractive Errors/physiopathology , Refractive Errors/psychology , Space Perception , Adolescent , Adult , Aged , Aged, 80 and over , Contrast Sensitivity , Female , Humans , Male , Miosis , Visual Acuity , Young Adult
6.
Opt Express ; 14(12): 5558-70, 2006 Jun 12.
Article in English | MEDLINE | ID: mdl-19516724

ABSTRACT

Ground based high-contrast imaging (e.g. extrasolar giant planet detection) has demanding wavefront control requirements two orders of magnitude more precise than standard adaptive optics systems. We demonstrate that these requirements can be achieved with a 1024-Micro-Electrical-Mechanical-Systems (MEMS) deformable mirror having an actuator spacing of 340 microm and a stroke of approximately 1 microm, over an active aperture 27 actuators across. We have flattened the mirror to a residual wavefront error of 0.54 nm rms within the range of controllable spatial frequencies. Individual contributors to final wavefront quality, such as voltage response and uniformity, have been identified and characterized.

7.
J Biophotonics ; 2(6-7): 398-406, 2009 Jul.
Article in English | MEDLINE | ID: mdl-19569116

ABSTRACT

Imaging the structure and correlating it with the biochemical content of the retina holds promise for fundamental research and for clinical applications. Optical coherence tomography (OCT) is commonly used to image the 3D structure of the retina and while the added functionality of biochemical analysis afforded by Raman scattering could provide critical molecular signatures for clinicians and researchers, there are many technical challenges to combine these imaging modalities. We describe an OCT microscope for ex-vivo imaging combined with Raman spectroscopy capable of collecting morphological and molecular information about a sample simultaneously. We present our first results and discuss the challenges to further development of this dual-mode instrument and limitations for future in-vivo retinal imaging.


Subject(s)
Retina/anatomy & histology , Spectrum Analysis, Raman/instrumentation , Tomography, Optical Coherence/instrumentation , Animals , Feasibility Studies , Humans , Image Processing, Computer-Assisted , In Vitro Techniques , Phantoms, Imaging , Spectrum Analysis, Raman/methods , Systems Integration , Time Factors , Tomography, Optical Coherence/methods
8.
Opt Lett ; 31(5): 565-7, 2006 Mar 01.
Article in English | MEDLINE | ID: mdl-16570399

ABSTRACT

Received October 11, 2005; accepted November 10, 2005; posted December 2, 2005 (Doc. ID 65234) We have measured a contrast of 6.5 x 10(-8) from 10 to 25 lambda/D in visible light on the Extreme Adaptive Optics testbed, using a shaped pupil for diffraction suppression. The testbed was designed with a minimal number of high-quality optics to ensure low wavefront error and uses a phase-shifting diffraction interferometer for metrology. This level of contrast is within the regime needed for imaging young Jupiter-like planets, a primary application of high-contrast imaging. We have concluded that wavefront error, not pupil quality, is the limiting error source for improved contrast in our system.

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