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1.
Morphologie ; 104(346): 217-220, 2020 Sep.
Article in English | MEDLINE | ID: mdl-32576529

ABSTRACT

INTRODUCTION: The pancreatic heterotopia of fortuitous operational discovery remains rare because of the medical imagery progress. We report a mesenteric localisation of aberrant pancreas identified during the assumption of responsibility of an abdominal emergency. OBSERVATION: A 26-year-old man was allowed with the urgencies for an acute obstruction of the small bowel. Surgical exploration revealed a distal support an ileo-parietal adherence near to an inflammatory hearth of appendicular origin. We noted, in addition to the mesentery of the first jejunal loop, a bilobate mass of glandular-like tissue with a pancreatic aspect. The adjacent jejunal handles were macroscopically healthy. The Pathological examination of the mass confirmed the existence of a mixed glandular exocrine and endocrine origin of pancreatic tissue, type I of the Heinrich's classification. CONCLUSION: This rare topographic entity of fortuitous discovery underlines the need for a meticulous surgical exploration of the abdominal cavity particularly in urgency when a summarized radiological assessment does not permit a complete morphological study.


Subject(s)
Mesentery , Pancreas , Adult , Humans , Male , Pancreas/anatomy & histology
2.
Clin Exp Immunol ; 196(1): 86-96, 2019 04.
Article in English | MEDLINE | ID: mdl-30580455

ABSTRACT

Merozoite surface proteins (MSPs) are critical for parasite invasion; they represent attractive targets for antibody-based protection against clinical malaria. To identify protection-associated target MSPs, the present study analysed antibody responses to whole merozoite extract (ME) and to defined MSP recombinant antigens in hospitalized patients from a low endemic urban area as a function of disease severity (mild versus cerebral malaria). Sera from 110 patients with confirmed severe cerebral malaria (CM) and 91 patients with mild malaria (MM) were analysed (mean age = 29 years) for total and subclass immunoglobulin (Ig)G to ME and total IgG to MSP1p19, MSP2, MSP3, MSP4 and MSP5 by enzyme-linked immunosorbent assay (ELISA). Functional antibody responses were evaluated using the antibody-dependent respiratory burst (ADRB) assay in a subset of sera. There was a trend towards higher IgG1 and IgG4 levels to ME in CM compared to MM; only ME IgM responses differed significantly between fatal and surviving CM patients. Increased prevalence of IgG to individual MSPs was found in the CM compared to the MM group, including significantly higher levels of IgG to MSP4 and MSP5 in the former. Sera from fatal (24·5%) versus surviving cases showed significantly lower IgG to MSP1p19 and MSP3 (P < 0·05). ADRB assay readouts correlated with high levels of anti-MSP IgG, and trended higher in sera from patients with surviving compared to fatal CM outcome (P = 0·07). These results document strong differential antibody responses to MSP antigens as targets of protective immunity against CM and in particular MSP1p19 and MSP3 as prognostic indicators.


Subject(s)
Antigens, Protozoan/immunology , Cell Extracts/immunology , Malaria, Cerebral/immunology , Malaria, Falciparum/immunology , Merozoites/immunology , Plasmodium falciparum/immunology , Urban Population , Adolescent , Adult , Aged , Antibodies, Protozoan/blood , Child , Child, Preschool , Disease Progression , Female , Hospitalization , Humans , Immunoglobulin M/blood , Infant , Malaria, Cerebral/mortality , Malaria, Falciparum/mortality , Male , Merozoite Surface Protein 1/immunology , Middle Aged , Recombinant Proteins/immunology , Survival Analysis , Treatment Outcome , Young Adult
3.
Prog Urol ; 28(7): 377-381, 2018 Jun.
Article in French | MEDLINE | ID: mdl-29627339

ABSTRACT

OBJECTIVE: To report our experience with anastomotic uretroplasty (AU) due to male urethral stricture disease (USD) and to identify factors affecting the results. PATIENTS AND METHODS: We conducted a retrospective study over a period of 4 years and 6 months (July 2012 to December 2016). Any subsequent use of endoscopic urethrotomy or new urethroplasty was considered a failure. RESULTS: Forty-eight cases were included. The mean age of patients was 53.5±17.3 years (23-87 years). Urinary retention was the reason for consultation in 42 cases (87.5%). The most common localization of USD was the bulbar urethra (n=45). The mean length of USD was 1.23±0.62cm (0.5-3cm) with a median length of 1cm. The etiology was post-infectious in 56.3% of cases. More than half (58.3%) of patients had already undergone at least one urethral manipulation. After an average follow-up of 21.1±12.6 months (1 to 52 months), the overall success rate was 77.1%. In univariate analysis, length, cause and location of the stricture, age of patient, the presenting symptoms of the stricture, previous urethral manipulation and surgeon experience did not significantly impact on the success rate of anastomotic urethroplasty at one and two years follow-up. CONCLUSION: The AU had provided good results in our practice. The infectious origin of the stricture and previous urethral manipulation did not significantly impact the result of this surgical technique. LEVEL OF EVIDENCE: 4.


Subject(s)
Anastomosis, Surgical/methods , Urethral Stricture/surgery , Urologic Surgical Procedures, Male/methods , Adult , Aged , Aged, 80 and over , Follow-Up Studies , Humans , Male , Middle Aged , Plastic Surgery Procedures/methods , Retrospective Studies , Treatment Outcome , Urethral Stricture/etiology , Urethral Stricture/pathology , Young Adult
4.
Prog Urol ; 24(12): 771-6, 2014 Oct.
Article in French | MEDLINE | ID: mdl-25158327

ABSTRACT

PURPOSE: To report our experience with Flexible Ureteroscopy-laser (FU-L) in the treatment of renal and/or ureteric stones. PATIENTS AND METHODS: We conducted a retrospective study of 191 kidney and/or ureteric stones treated in the urology department of New Civil Hospital (Strasbourg) over a period of 2 years. Two hundred and nineteen FU-L were performed. We were interested in the indications of FU-L, its complications, treatment outcomes and predictors of obtaining a stone-free outcome. Postoperative complications were reported according to the Clavien-Dindo classification. RESULTS: The indications were first line in 62.3% of cases, failures of shock wave lithotripsy in 26.2% of cases and failure of alkalinization of urine in 5.2% of cases. As intraoperative complications, we had one case of ureteropelvic avulsion and one case of bronchospasm leading to stop ureteroscopy. Postoperative complications occurred after 38 FU-L (17.3%). All grades combined these postoperative complications were infectious in 50% of cases. They were grade I, II, III, IV and V respectively in 5.9; 7.3; 2.7; 1.3 et 0% of cases. Their occurrence was not significantly correlated to the size of the stones or the unilateral or bilateral nature of the FU-L. The overall rate of stone-free was 71.7%. The factors determining significantly a stone-free outcome were the size of kidney stone and experience of the operator. CONCLUSION: In our center, the FU-L is increasingly used as first-line option due to its low morbidity and excellent results especially for the treatment of kidney stones less than 20mm and ureteric stones. It is a quality alternative to PCNL in kidney stones over 20mm.


Subject(s)
Kidney Calculi/therapy , Lithotripsy, Laser , Ureteral Calculi/therapy , Ureteroscopy , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Retrospective Studies , Treatment Outcome , Young Adult
5.
Prog Urol ; 24(6): 346-8, 2014 May.
Article in French | MEDLINE | ID: mdl-24821556

ABSTRACT

Scrotal calcinosis is a rare pathology and etiology still discussed. We report five cases in patients without particular history of another disease. Clinical examination revealed scrotal wall with painless nodules of various sizes producing a whitish substance, pasty. The phosphate levels were normal in all patients. They all had a resection of the lesions associated with scholarships plasty recovery. Histopathological study revealed calcified epidermoid cysts in 4 cases.


Subject(s)
Calcinosis/etiology , Epidermal Cyst/pathology , Genital Diseases, Male/pathology , Scrotum/pathology , Urologic Surgical Procedures, Male , Adult , Calcinosis/surgery , Epidermal Cyst/complications , Epidermal Cyst/surgery , Genital Diseases, Male/etiology , Genital Diseases, Male/surgery , Humans , Male , Middle Aged , Scrotum/surgery , Treatment Outcome , Urologic Surgical Procedures, Male/methods
6.
Prog Urol ; 24(10): 665-9, 2014 Sep.
Article in French | MEDLINE | ID: mdl-25214297

ABSTRACT

PURPOSE: To describe the epidemiological, anatomico-clinical and therapeutic aspects of the patent vaginoperitoneal canal (PVPC) in urological practice and to compare our results with those of pediatric teams. PATIENTS AND METHODS: We performed a retrospective descriptive study of PVPC cases operated in a urology unit. The following parameters were studied: medical history, age, method of installation, the anatomo-clinical type, side and the results of the treatment. RESULTS: A total of 163 cases were collected over a period of 5 years. The average age was 7.5 ± 7 years with a range of 2 months and 39 years. Thirty-four patients had less than or equal to age 2 ears and 28 patients were adults. The reason for consultation was an inguinal or scrotal inguinal, painless and intermittent swelling in 72.3% of cases. Installation mode was progressive in 45 patients (27.6%). The PVPC was sitting right in 81 patients (49.7%) and was bilateral in 12 patients (7.3%). The anatomo-clinical types were dominated by the communicating hydrocele (52%). The treatment was carried out in controlled surgery in all patients and the mean duration of hospitalization was 24 hours. The postoperative course was marked by 5 cases of scrotal hematoma and 2 cases of parietal suppuration. Postoperative mortality was zero. After a mean postoperative decrease of 2 years we observed 3 cases of testicular atrophy and two recurrences. CONCLUSION: Our results in terms of morbidity and mortality although satisfactory were lower than those of pediatric teams. LEVEL OF EVIDENCE: 5.


Subject(s)
Cysts/congenital , Cysts/surgery , Hernia, Inguinal/congenital , Hernia, Inguinal/surgery , Peritoneum/abnormalities , Peritoneum/surgery , Spermatic Cord , Testicular Hydrocele/congenital , Testicular Hydrocele/surgery , Adolescent , Child , Child, Preschool , Genital Diseases, Male/complications , Genital Diseases, Male/surgery , Humans , Infant , Male , Retrospective Studies , Urologic Surgical Procedures, Male/methods , Young Adult
7.
Prog Urol ; 24(1): 67-9, 2014 Jan.
Article in French | MEDLINE | ID: mdl-24365632

ABSTRACT

Bilharzioma are inflammatory pseudotumors, which often pose the problem of differential diagnosis with neoplastic processes. Using the keywords "testicular" and "schistosomiasis", there are only 14 cases of testicular bilharzioma identified on PubMed. The authors report two new cases in a 6-year-old child and an adult of 38 years, collected over a period of 5 years. In both cases, orchidectomy was performed and histological analysis of the surgical specimen was allowed to diagnose testicular bilharzioma by Schistosomia haematobium. The authors emphasize the need to evoke a bilharzioma before any testicular nodule in a patient living in an endemic area.


Subject(s)
Schistosomiasis haematobia , Testicular Diseases/parasitology , Adult , Child , Humans , Male , Schistosomiasis haematobia/diagnosis , Schistosomiasis haematobia/surgery , Testicular Diseases/diagnosis , Testicular Diseases/surgery
8.
Prog Urol ; 23(10): 884-9, 2013 Sep.
Article in French | MEDLINE | ID: mdl-24034801

ABSTRACT

OBJECTIVE: Describe the epidemiology, diagnosis and treatment of vesicovaginal fistula (VVF). PATIENTS AND METHODS: We conducted a retrospective descriptive study of all cases of VVF secondary to hysterectomy. The following parameters were studied: age, parity, indication for hysterectomy, risk factors, the consultation period, the anatomical type of VVF, the paraclinical, the surgical approach and results of the cure. RESULTS: Fourteen cases were identified over 10 years. All hysterectomies were performed by laparotomia. The average age of patients was 54.3±13 years. Hysterectomy was performed in view of a uterine leiomyoma in eight cases, a cancer of the cervix in four cases, a menometrorrhagia in one case and a choriocarcinoma in one case. Four patients had received neoadjuvant radiotherapy. The mean time from injury was 13.5±18 months. Examination under valve was allowed to find 11 VVF type 1 and three type 2 VVF. IVU was normal in seven patients and allowed to find an ureterohydronephrose stage III in one patient. VVF was addressed by high in ten cases including 5 by transperitoneovaginale and 5 by transvesical pure. The postoperative course was uneventful in 11 patients (78%) but marked by vesicocutaneous fistula, parietal suppuration and one failure. CONCLUSION: In this short series of post-hysterectomy VVF treated by laparotomia, we observed a rate of cure satisfying in spite of an important psychosocial morbidity.


Subject(s)
Hysterectomy/adverse effects , Vesicovaginal Fistula/etiology , Adult , Aged , Choriocarcinoma/therapy , Female , Humans , Leiomyoma/surgery , Middle Aged , Parity , Radiotherapy, Adjuvant/statistics & numerical data , Retrospective Studies , Risk Factors , Time-to-Treatment , Uterine Cervical Neoplasms/therapy , Uterine Neoplasms/surgery , Vesicovaginal Fistula/surgery
9.
Prog Urol ; 22(16): 1010-4, 2012 Dec.
Article in French | MEDLINE | ID: mdl-23178097

ABSTRACT

OBJECTIVES: To evaluate the results of Anderson-Hynes open pyeloplasty in our institution. And then to compare them to those of laparoscopic procedure and identify what can be considered now as the indications of the open procedure. PATIENTS AND METHODS: It was a retrospective study on 30 cases of ureteropelvic junction syndrome managed by Anderson-Hynes open procedure. The clinical, biological and radiologic characteristics of the patients as well as the surgical technique and its results were taken into account. The patients were classified, according to Valdeyer and Cendron classification as type II in eight cases (26.7%), type III in ten cases (33.3%) and type IV in four cases (13.3%). There were also eight cases of giant hydronephrosis (26.7%). The operating time, the length of hospital stay and the outcomes were studied and compared with those of the laparoscopic pyeloplasty found in the medical literature. RESULTS: The mean operating time was 115 ± 33.4 minutes (90-230 min). The mean length of hospital stay was 10.4 ± 5.1 days. Six patients (20%) had postoperative complications. After a mean follow-up of 28 ± 13.7 months (13-48 months), our first-hand success rate was 90% (n=27). CONCLUSION: Anderson-Hynes open pyeloplasty reached good results but nowadays its indications can be limited to laparoscopic contraindications, severe hydronephrosis (grade IV or giant hydronephrosis) and second-hand cases. The two latter indications depend on the surgeon experience in laparoscopic surgery.


Subject(s)
Hydronephrosis/surgery , Kidney Pelvis/surgery , Laparoscopy , Ureteral Obstruction/surgery , Urologic Surgical Procedures/methods , Adolescent , Adult , Child , Child, Preschool , Dilatation, Pathologic , Female , Follow-Up Studies , Humans , Hydronephrosis/diagnosis , Kidney Pelvis/pathology , Laparoscopy/methods , Length of Stay , Male , Middle Aged , Retrospective Studies , Severity of Illness Index , Syndrome , Time Factors , Treatment Outcome
10.
Med Trop (Mars) ; 71(5): 495-8, 2011 Oct.
Article in French | MEDLINE | ID: mdl-22235626

ABSTRACT

PURPOSE: To report epidemiological, clinical and paraclinical features of pyonephrosis and describe current management methods in Senegal. PATIENTS AND METHODS: This retrospective study includes a series of patients admitted for pyonephrosis to the Urology Department of the Aristide Le Dantec Hospital in Dakar between 1995 and 2009. The following information was collected for each patient: age, sex, clinical manifestations, diagnostic findings, treatment modalities and outcomes. RESULTS: A total of 44 patients with a mean age of 34 years were included. The most common clinical manifestations were acute flank pain, sepsis and renal mass. Diagnostic was usually based on medical imaging, i.e., renal utrasonography and computed tomography. Urolithiasis was the underlying etiology in 73.2% of cases. Nephrectomy was performed in 83% of cases with or without preliminary nephrostomy catheterization. CONCLUSION: Development of both diagnostic (medical imaging) and therapeutic methods for management of pyonephrosis has been consistent with the rarity of this condtion in Senegal.


Subject(s)
Pyonephrosis/diagnosis , Pyonephrosis/therapy , Adolescent , Adult , Aged , Anti-Bacterial Agents/therapeutic use , Child , Child, Preschool , Diagnostic Imaging , Female , Flank Pain/etiology , Humans , Male , Middle Aged , Nephrectomy/statistics & numerical data , Pyonephrosis/etiology , Retrospective Studies , Senegal/epidemiology , Sepsis/etiology , Urolithiasis/complications , Young Adult
11.
Med Trop (Mars) ; 71(6): 613-4, 2011 Dec.
Article in French | MEDLINE | ID: mdl-22393631

ABSTRACT

The purpose of this report is to describe four cases of nocardiosis observed over an eight-year period in medical units of Principal Hospital in Dakar, Senegal. It is a rare infection occurring mainly in people with weakened immune systems. Pulmonary forms are predominate and clinical and laboratory presentation can mimic pulmonary tuberculosis. Diagnosis should be suspected in patients presenting pulmonary infections and negative sputum bacilloscopy. Nocardia bacteria should be identified before starting antibiotic treatment. Patients require long-term antibiotic treatment with third generation cephalosporins or sulfamethoxazole-trimethoprim.


Subject(s)
Nocardia Infections/diagnosis , AIDS-Related Opportunistic Infections/complications , AIDS-Related Opportunistic Infections/diagnosis , AIDS-Related Opportunistic Infections/drug therapy , Adult , Anti-Bacterial Agents/therapeutic use , Diagnosis, Differential , Female , HIV Infections/complications , HIV Infections/drug therapy , HIV-1/physiology , Humans , Immunocompromised Host/physiology , Male , Middle Aged , Nocardia Infections/drug therapy , Nocardia Infections/etiology , Radiography, Thoracic , Senegal , Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use , Tuberculosis, Pulmonary/diagnosis
12.
Prog Urol ; 21(8): 521-6, 2011 Sep.
Article in French | MEDLINE | ID: mdl-21872154

ABSTRACT

OBJECTIVE: To study current epidemiological and clinical features of adult renal cancer in Senegal and the evolution of these features over the two past decades. PATIENTS AND METHODS: We conducted a retrospective ten years study (2000-2009) that analyzed all the renal cell cancer in adult admitted in the urology department and the pathology department of the university teaching hospital Aristide-Le-Dantec (Dakar). The results of this study were compared with those of the previous decade. RESULTS: We included 74 cases of renal cell cancer. The median age of patients was 49 years (18-72 years). There was a slight female predominance (51.3%). Twenty-eight (37.8%) patients presented at least with one renal cell cancer risk factor. The median duration of symptoms was 10 months (1-96 months). The localization of the renal cancer was right in 42 patients (56.7%) and left in 32 cases (43.8%). Almost all the tumors were symptomatic. Symptoms were dominated by loin pain (87.8%) and abdominal mass (77%). There were only two cases (2.7%) of incidental renal cell cancer. The median tumor size was 12 cm (2.4-26 cm). The more frequent tumor stages according to the TNM 2002 staging system were T2 (39.2%) and T3 (33.7%). Metastases were found in 23 (31%) patients. Forty-four patients underwent nephrectomy (43 radical and one partial). No adjuvant treatment or metastasectomy were done. The main histological subtype of tumors was renal cell carcinoma (47 cases). The mean duration of the follow up was 30.5 ± 33.6 months. Among the 44 patients who underwent nephrectomy, no tumor recurrence was found on 35 cases. Tumor recurrence occurred on nine patients. The specific mortality rate was 47.3%. Epidemiological and clinical features of the adult renal cell cancer in Senegal haven't significantly changed over the 20 past years. CONCLUSION: The adult renal cell cancer incidence was low in Senegal. Its clinical profile was characterized by a predominance of locally advanced and metastatic forms.


Subject(s)
Carcinoma, Renal Cell/diagnosis , Carcinoma, Renal Cell/epidemiology , Kidney Neoplasms/diagnosis , Kidney Neoplasms/epidemiology , Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Retrospective Studies , Senegal/epidemiology , Time Factors , Young Adult
13.
Med Trop Sante Int ; 1(3)2021 09 30.
Article in French | MEDLINE | ID: mdl-35686171

ABSTRACT

The population's adherence to preventive measures is crucial for the success of the fight against the Covid-19 epidemic, whether it is a question of respecting barrier gestures or vaccination. We conducted a socio-anthropological survey in five countries of the Economic Community of West African States (Burkina Faso, Cape Verde, Côte d'Ivoire, Guinea Bissau, and Sierra Leone) on the representations of Covid-19 that may influence this adherence. Our results showed that raising the awareness of barrier gestures was extremely well-received by the population and is perfectly understood, but that a substantial part of the population denies the presence of Covid-19 in their country, that the transmission of SARS-CoV2 by asymptomatic persons is mostly ignored, that the risk factors of severe forms of the disease are insufficiently known and that a majority of the respondents fear contracting Covid-19 when visiting a health center. The "infodemia" circulating on social networks does not seem to contribute to the various misconceptions we have highlighted, which are the product of the interviewees' observations and interpretation. We propose a reorientation of communication about Covid-19 based on the results of our survey.


Subject(s)
COVID-19 , COVID-19/epidemiology , Communication , Cote d'Ivoire , Humans , RNA, Viral , SARS-CoV-2 , Surveys and Questionnaires
14.
Med Trop (Mars) ; 70(4): 367-70, 2010 Aug.
Article in French | MEDLINE | ID: mdl-22368935

ABSTRACT

INTRODUCTION: The bacteriological characteristics of Helicobacter pylori (HP) vary in function of time and place. The aim of this study was to update histological and bacteriological feature of HP infection in patients presenting gastroduodenal lesions in Dakar, Senegal. PATIENTS AND METHOD: This prospective study included patients with gastroduodenal lesions managed over a 6-month period in a digestive endoscopy center in Dakar. In all cases gastric biopsy was performed to obtain specimens for histological diagnosis according Sydney modified classification and HP culture with antibiogram. RESULTS: A total of 158 patients were included. Mean patient age was 48.7 years and the sex-ratio was 1.2. Endoscopic lesions were ulcer in 88 cases, gastritis in 54 cases and tumors in 16. Histological examination demonstrated chronic gastritis in 100% of cases, inflammatory activity in 79.1%, metaplasia in 78.5%, gastric atrophy in 41.1%, adenocarcinoma in 7.6%, dysplasia in 5.7%, and MALT lymphoma in 2.5% with presence of HP in 72.8% of cases. Cultures were positive for HP in 65.8% of cases. Antibiograms indicated that HP was sensitive to amoxicilline in 100% of cases, clarithromycine in 96.6%, ciprofloxacine in 84.1%, and métronidazole in 29.5%. CONCLUSION: Chronic gastritis is a constant feature of gastroduodenal lesions in Dakar. Histology combined with culture showed HP infection in 78.5% of cases. The antibiotic sensitivity of HP in Dakar has changed over the past decade.


Subject(s)
Gastrointestinal Diseases/microbiology , Helicobacter Infections/diagnosis , Adolescent , Adult , Aged , Aged, 80 and over , Anti-Bacterial Agents/therapeutic use , Child , Chronic Disease , Female , Gastrointestinal Diseases/drug therapy , Gastrointestinal Diseases/epidemiology , Helicobacter Infections/drug therapy , Helicobacter Infections/epidemiology , Helicobacter pylori , Humans , Male , Middle Aged , Prospective Studies , Senegal/epidemiology , Young Adult
15.
Med Trop (Mars) ; 70(5-6): 475-8, 2010 Dec.
Article in French | MEDLINE | ID: mdl-21520650

ABSTRACT

UNLABELLED: To describe clinical and therapeutic features of ischemic priapism associated with sickle cell disease (SSD) in Senegalese men and to identify risk factors for erectile dysfunction (ED). PATIENTS AND METHODS: The charts of all patients admitted to the Urology Department of Aristide Le Dantec University Teaching Hospital (Dakar) for ischemic priapism associated with SSD between January 2000 and September 2008 were retrospectively reviewed. RESULTS: A total of 22 patients with a mean age of 19.5 +/- 9.9 years (6 - 41 years) were identified. The most affected age group was between 21 and 30 years. The mean duration between onset of the episode and admission was 89.6 +/- 103.1 hours (4 - 384 hours). Nine patients (40.9%) were admitted within 24 hours after the onset. Eight patients (36.3%) had a history of stuttering priapism. The sickle cell phenotype identified by electrophoresis was SS in 18 patients and AS in four. The main treatment modalities were corporeal aspiration that was performed with or without intracavernosal injection of sympathomimetics drugs and Al Ghorab shunt surgery that was used in ten patients with a success rate of 90 % (complete detumescence). With a mean follow-up of 3.8 +/- 1.5 years, nine (69.2%) of the 13 patients older than 16 years developed ED. The incidence of ED was significantly correlated with the duration of the priapism but not with SSD phenotype. CONCLUSION: In Senegal ischemic priapism associated with sickle cell disease occurs mainly in young people. The incidence of ischemic priapism appears to be low but ED is common due to the prolonged duration of priapism.


Subject(s)
Anemia, Sickle Cell/complications , Erectile Dysfunction/etiology , Priapism/etiology , Acute Disease , Adolescent , Adult , Child , Follow-Up Studies , Humans , Male , Retrospective Studies , Risk Factors , Senegal , Young Adult
16.
Prog Urol ; 22(6): 344-9, 2010 May.
Article in French | MEDLINE | ID: mdl-22541904

ABSTRACT

PURPOSE: To report the oncologic results and morbidity of bilateral pulpectomy and to identify factors that make this method of androgen suppression therapy the most used in our country. PATIENTS AND METHODS: We conducted a prospective study in the urology department of Aristide Le-Dantec hospital (Dakar) between January 2008 and June 2010 (30 months). It included 84 cases of prostate cancer treated by bilateral pulpectomy under local anesthesia. RESULTS: The mean age of patients was 72.17±12.48 years (53-91). The median PSA level was 101 ng/mL (12.18-9990). Metastasis have been detected in 75% of cases. The Gleason score was higher than 7 in 40 patients (47.6%). Three months after pulpectomy, an improvement of performance status was seen in 76 patients (90.4%). The back pain significantly decreased in intensity or disappeared in 65.3% (32/49) of cases. A complete recovery of lower limbs motor deficit was observed in 50% of cases (7/14). The PSA levels decreased in 57 of the 76 patients alive and the mean PSA level was then 72±11.7 ng/mL (3.8-2433). At six months, of the 53 patients in urinary retention, 18 had recovered spontaneous and complete urination. The PSA level was below 4 ng/mL in 33.8% (22/65) of cases and between 4 and 10 ng/mL in 52.3% (34/65) of cases. At 12 months, the median PSA nadir was 0.76 ng/mL (0,002-8,17) and 57.4% of the 54 patients alive had a PSA nadir less than 2 ng/mL. The mean follow-up was 11.08±10.34 months (1-30). A rising PSA occurred in 17 patients (20.2%) after an mean progression-free survival of 10.5 months (6-25). The overall survival at 6, 12 and 24 months were respectively 77.3, 64.3 and 52.3%. The overall cost of pulpectomy was 50 000 FCFA (76€). The specific morbidity of pulpectomy was two cases (2.4%) of infection of the operative site. CONCLUSION: The bilateral pulpectomy was a method of androgen suppression immediately effective, efficacious with a low morbidity. Its very low cost is the main reason why it is still the most used method in our country.


Subject(s)
Orchiectomy/methods , Prostatic Neoplasms/surgery , Aged , Aged, 80 and over , Humans , Male , Middle Aged , Prospective Studies
17.
Prog Urol ; 19(2): 101-6, 2009 Feb.
Article in French | MEDLINE | ID: mdl-19168012

ABSTRACT

OBJECTIVE: To assess the feasibility of selective clamping of segmental renal arteries during partial nephrectomy, in order to limit renal infarction to the pathological area to be resected. MATERIALS AND METHODS: A dissection of renal artery and its extraparenchymal branches was realised. The study included 30 kidneys from recent nonformolised corpses. The size, distribution, and accessibility of the arteries were considered. All the corpses underwent a lombotomy with or without rib resection. RESULTS: The majority of dissected kidneys had a unique artery (96.66% of cases). The number of segmental arteries was zero in five cases (16.66%), one in four cases (13.33%), two in four cases (13.33%), three in one case (3%), four in 15 cases (50%) and five in five cases (16.66%). The posterior and inferior segmental arteries were more accessible to isolate with a respective ratio of 94 and 100% at segmental level. Apical and middle segmental arteries were least accessible with a respective ratio of 73 and 80%. The majority of accidents during dissection occurred with the middle segmental artery (62.5% of vascular lesions). CONCLUSION: This anatomic dissection on corpses showed that selective renal segmental arteries is possible in the majority of cases. This dissection is better indicated in partial nephrectomies for renal tumours located posteriorly or in the lower pole.


Subject(s)
Nephrectomy/methods , Renal Artery , Adult , Cadaver , Constriction , Feasibility Studies , Female , Humans , Male
18.
Arch Pediatr ; 15(9): 1393-7, 2008 Sep.
Article in French | MEDLINE | ID: mdl-18757186

ABSTRACT

OBJECTIVE: Sickle cell disease is a public health problem in Africa. The aim of this prospective study was to evaluate per and post-operative complications of laparoscopic cholecystectomy in sickle cell children in Senegal. METHODS: from January 1999 to December 2006, an anesthetic protocol was applied to 39 sickle cell children undergoing a cholecystectomy. Among them, 20 experienced laparoscopic cholecystectomy. RESULTS: All these 20 patients had previously suffered from sickle cell visceral complications and were classified as ASA II (11 cases) and as ASA III (9 cases). Blood transfusion program aimed at sustaining haemoglobin level between 10 and 12 g/dl was implemented. The preoperative monitoring and anesthesia management were the same for these patients. During perioperative period, the prevention of pain, hypovolemia, hypothermia and acidosis was achieved. The mean insufflation duration of laparoscopy was 23 min (17-60 min), the mean surgery duration was 55 min (40-110 min), and the mean anesthesia duration was 78 min (88-135 min). Postoperative complications occurred in 9 patients: acute chest syndrome (n=2), postoperative hemolysis (n=5), vaso-occlusive crisis (n=2). CONCLUSION: Laparoscopic cholecystectomy can be carried out in sickle cell children affected with gallstones, provided that general anaesthetic rules were respected. An appropriate pre-, per- and postoperative anaesthesia is mandatory to reduce postoperative complications in children with sickle cell disease. Searching for early diagnosis of gallstones before occurrence of visceral complications should allow further optimal laparoscopic surgery.


Subject(s)
Anemia, Sickle Cell/complications , Cholecystectomy, Laparoscopic , Perioperative Care , Adolescent , Child , Gallstones/surgery , Humans , Prospective Studies
19.
Dakar Med ; 53(1): 32-7, 2008.
Article in French | MEDLINE | ID: mdl-19102115

ABSTRACT

Management of exocrine pancreatic tumors is very difficult: Their impact is in upsurge and their diagnosis is very often made to an advanced stage that only allows the therapeutic palliative. To value the management of these tumors to the surgical clinic of Aristide Le Dantec hospital, authors achieved a retrospective survey on 8years (October 1994 to October 2002). Hundred twenty nine (129) cases of exocrine pancreatic tumors had been counted. It was about 71 men and 58 women of middle age of 56, 96 years. The length of middle evolution of the illness was of 8 months. The most frequent sign was jaundice, recovered at 80.9% of patients. Followed the thinning (79%), the pain (69%), the digestive stenosis (35%). Ultrasonography, scanner and x-ray of lungs permitted to make the diagnosis and the balance of extension. A laparoscopy had been made at 13 patients. A clinic and radiological classification had been used to distribute the tumors in 3 stages. At 46 patients in III stage, a therapeutic abstention had been decided. Patients to the II stage (n=77) had benefitted a palliative surgical treatment. It was about 74 biliary and digestive shunt and 3 alcoholic splanchnicectomy. The 6 patient to the I stage had benefitted a surgical resection. The middle hospitalization length was of 10.75 days. The rate of morbidity was 45.78%. Mortality was 29%. The median survival was of 3.6 months. The palliative surgical treatment had again indications facing these obstructive and locally advanced tumors. But the salute will come from the precocious diagnosis of these tumors to hope for a curative gesture.


Subject(s)
Pancreatic Neoplasms , Adult , Aged , Aged, 80 and over , Female , Humans , Laparoscopy , Male , Middle Aged , Neoplasm Staging , Palliative Care , Pancreas/pathology , Pancreatic Neoplasms/diagnosis , Pancreatic Neoplasms/diagnostic imaging , Pancreatic Neoplasms/mortality , Pancreatic Neoplasms/pathology , Pancreatic Neoplasms/surgery , Pancreaticoduodenectomy , Retrospective Studies , Time Factors , Tomography, X-Ray Computed
20.
Prog Urol ; 18(1): 71-3, 2008 Jan.
Article in French | MEDLINE | ID: mdl-18342160

ABSTRACT

Abdominoscrotal hydrocele is a very rare clinical entity especially in childhood with less than 100 paediatric cases reported in the literature. It is associated with various complications and its pathogenesis is still a matter for debate. The authors report a case of abdominoscrotal hydrocele in the child. The methods of the diagnosis as well as the specific treatment are pointed out.


Subject(s)
Hydronephrosis/complications , Testicular Hydrocele/complications , Testicular Hydrocele/surgery , Ureteral Diseases/complications , Child , Humans , Hydronephrosis/diagnosis , Male , Testicular Hydrocele/diagnostic imaging , Ultrasonography , Ureteral Diseases/diagnosis
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