Prediction of household wastewater treatment systems' in situ performance based on standardized tests.

This paper presents a comparative analysis on operating conditions of onsite wastewater treatment systems. Actual EU Member States' national regulations require in situ treatment thresholds expressed in effluent concentrations. CE marking of onsite wastewater treatment system is mandatory according to standardized test (EN 12566-3 + A2) with performance declared in removal efficiency. Recent study indicates that in situ raw sewage concentrations are 1.5 times higher than those on test platforms. In this context, performance comparison between platform tests and in situ discharge threshold cannot be based on effluent concentrations but rather on removal efficiency to fulfill environmental and health requirements. This study compares: (i) results from eight standardized tests, (ii) over 300 measurements of in situ raw sewage, and (iii) several national-level thresholds focusing on carbon parameters. To meet French effluent thresholds, a minimum removal efficiency of 96% in SS and 95% in BOD5 is required. A beta law model assesses the efficiency measured during standardized testing and establishes a robustness characteristic with a probability above 80%. When a septic tank is used, its efficiency can be incorporated into the prediction. Although the new performance criteria are more stringent, some of the eight products evaluated still meet the requirements.

[Healthy eating counseling : Clinical and community perspectives]. / Conseils pour une alimentation saine : perspectives cliniques et communautaires.

Given the significant impact of diet on human health and its role in the primary and secondary prevention of many diseases, interventions aimed at modifying dietary behavior are increasingly considered as medical interventions. In this context, clinicians need more education and training on the appropriateness and use of these interventions, including the prescription of therapeutic meals. Both in-office counselling, for example with a dietician, and structural public health measures improve dietary behaviours. These coordinated clinical and community actions are important to reverse the unbalanced dietary trends observed in national surveys in Switzerland.

Vu l'impact important de l'alimentation sur la santé humaine et son rôle dans la prévention primaire et secondaire de nombreuses maladies, les interventions visant à modifier le comportement alimentaire tendent de plus en plus à être considérées comme des interventions médicales. Dans ce contexte, les cliniciens ont besoin de plus d'éducation et de formation sur la pertinence et l'utilisation de ces interventions, notamment pour la prescription de repas thérapeutiques. Autant le conseil au cabinet, par exemple en interprofessionnalité avec un·e diététicien·ne, que les mesures structurelles de santé publique améliorent les comportements alimentaires. Ces actions coordonnées cliniques et communautaires sont importantes pour faire évoluer les tendances alimentaires non équilibrées, observées lors d'enquêtes nationales en Suisse.

Hydrogen molecular ions and the violent birth of the Solar System.

Many pieces of evidence indicate that the Solar System youth was marked by violent processes: among others, high fluxes of energetic particles (greater than or equal to 10 MeV) are unambiguously recorded in meteoritic material, where an overabundance of the short-lived 10Be products is measured. Several hypotheses have been proposed to explain from where these energetic particles originate, but there is no consensus yet, mostly because of the scarcity of complementary observational constraints. In general, the reconstruction of the past history of the Solar System is best obtained by simultaneously considering what we know of it and of similar systems nowadays in formation. However, when it comes to studying the presence of energetic particles in young forming stars, we encounter the classical problem of the impossibility of directly detecting them toward the emitting source (analogously to what happens to galactic cosmic rays). Yet, exploiting the fact that energetic particles, such as cosmic rays, create [Formula: see text] and that an enhanced abundance of [Formula: see text] causes dramatic changes on the overall gas chemical composition, we can indirectly estimate the flux of energetic particles. This contribution provides an overview of the search for solar-like protostars permeated by energetic particles and the discovery of a protocluster, OMC-2 FIR4, where the phenomenon is presently occurring. This article is part of a discussion meeting issue 'Advances in hydrogen molecular ions: H3+, H5+ and beyond'.

Rumor Classification through a Multimodal Fusion Framework and Ensemble Learning.

The proliferation of rumors on social media has become a major concern due to its ability to create a devastating impact. Manually assessing the veracity of social media messages is a very time-consuming task that can be much helped by machine learning. Most message veracity verification methods only exploit textual contents and metadata. Very few take both textual and visual contents, and more particularly images, into account. Moreover, prior works have used many classical machine learning models to detect rumors. However, although recent studies have proven the effectiveness of ensemble machine learning approaches, such models have seldom been applied. Thus, in this paper, we propose a set of advanced image features that are inspired from the field of image quality assessment, and introduce the Multimodal fusiON framework to assess message veracIty in social neTwORks (MONITOR), which exploits all message features by exploring various machine learning models. Moreover, we demonstrate the effectiveness of ensemble learning algorithms for rumor detection by using five metalearning models. Eventually, we conduct extensive experiments on two real-world datasets. Results show that MONITOR outperforms state-of-the-art machine learning baselines and that ensemble models significantly increase MONITOR's performance.

High-LET radiation-induced response of microvessels in the Hippocampus.

The hippocampus is critical for learning and memory, and injury to this structure is associated with cognitive deficits. The response of the hippocampal microvessels after a relatively low dose of high-LET radiation remains unclear. In this study, endothelial population changes in hippocampal microvessels exposed to (56)Fe ions at doses of 0, 0.5, 2 and 4 Gy were quantified using unbiased stereological techniques. Twelve months after exposure, mice that received 0.5 Gy or 2 Gy of iron ions showed a 34% or 29% loss of endothelial cells, respectively, in the hippocampal cornu ammonis region 1 (CA1) compared to age-matched controls or mice that received 4 Gy (P < 0.05). We suggest that this "U-shaped" dose response indicates a repopulation from a sensitive subset of endothelial cells that occurred after 4 Gy that was stimulated by an initial rapid loss of endothelial cells. In contrast to the CA1, in the dentate gyrus (DG), there was no significant difference in microvessel cell and length density between irradiated groups and age-matched controls. Vascular topology differences between CA1 and DG may account for the variation in dose response. The correlation between radiation-induced alterations in the hippocampal microvessels and their functional consequences must be investigated in further studies.

Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors.

Integrin alpha5beta1 is among the proteins overexpressed on tumor vessels and is a potential target for diagnostics and therapeutics. Here, we mapped the distribution of alpha5beta1 integrin in three murine tumor models and identified sites of expression that are rapidly accessible to intravascular antibodies. When examined by conventional immunohistochemistry, alpha5beta1 integrin expression was strong on most blood vessels in RIP-Tag2 transgenic mouse tumors, adenomatous polyposis coli (apc) mouse adenomas, and implanted MCa-IV mammary carcinomas. Expression increased during malignant progression in RIP-Tag2 mice. However, immunoreactivity was also strong in normal pancreatic ducts, intestinal smooth muscle, and several other sites. To determine which sites of expression were rapidly accessible from the bloodstream, we intravenously injected anti-alpha5beta1 integrin antibody and 10 minutes to 24 hours later examined the amount and distribution of labeling. The injected antibody strongly labeled tumor vessels at all time points but did not label most normal blood vessels or gain access to pancreatic ducts or intestinal smooth muscle. Intense vascular labeling by anti-alpha5beta1 integrin antibody co-localized with the uniform CD31 immunoreactivity of tumor vessels and contrasted sharply with the patchy accumulation of nonspecific IgG at sites of leakage. This strategy of injecting antibodies revealed the uniform overexpression and rapid accessibility of alpha5beta1 integrin on tumor vessels and may prove useful in assessing other potential therapeutic targets in cancer.

Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung.

Profiling gene expression in endothelial cells advances the understanding of normal vascular physiology and disease processes involving angiogenesis. However, endothelial cell purification has been challenging because of the difficulty of isolating cells and their low abundance. Here we examine gene expression in endothelial cells freshly isolated from lung capillaries after in vivo labeling with fluorescent cationic liposomes and purification by fluorescence-activated cell sorting (FACS). Of the 39,000 genes and expressed sequence tags evaluated on custom oligonucleotide arrays, 555 were enriched in endothelial cell fraction. These included familiar endothelial cell-associated genes such as VEGF, VEGF receptor (VEGFR)-1, VEGFR-2, angiopoietin-2, Tie1, Tie2, Edg1 receptor, VE-cadherin, claudin 5, connexin37, CD31, and CD34. Also enriched were genes in semaphorin/neuropilin (Sema3c and Nrp1), ephrin/Eph (ephrin A1, B1, B2, and EphB4), delta/notch (Hey1, Jagged 2, Notch 1, Notch 4, Numb, and Siah1b), and Wingless (Frizzled-4 and Tle1) signaling pathways involved in vascular development and angiogenesis. Expression of representative genes in alveolar capillary endothelial cells was verified by immunohistochemistry. Such expression reflects features that endothelial cells of normal lung capillaries have in common with embryonic and growing blood vessels. About half of the enriched genes, including exostosin 2, lipocalin 7, phospholipid scramblase 2, pleckstrin 2, protocadherin 1, Ryk, scube 1, serpinh1, SNF-related kinase, and several tetraspanins, had little or no previous association with endothelial cells. This approach can readily be used to profile genes expressed in blood vessels in tumors, chronic inflammation, and other sites in which endothelial cells avidly take up cationic liposomes.