BrainForest: Neuromorphic Multiplier-Less Bit-Serial Weight-Memory-Optimized 1024-Tree Brain-State Classification Processor.

Personalized brain implants have the potential to revolutionize the treatment of neurological disorders and augment cognition. Medical implants that deliver therapeutic stimulation in response to detected seizures have already been deployed for the treatment of epilepsy. These devices require low-power integrated circuits for life-long operation. This constraint impedes the integration of machine-learning driven classifiers that could improve treatment outcomes. This paper introduces BrainForest, a neuromorphic multiplier-less bit-serial weight-memory-optimized brain-state classification processor. The architecture achieves state-of-the-art energy efficiency using two layers of neuron models to implement the spectral and temporal functions needed for classification: 1) resonate-and-fire neurons are used to extract physiological signal band energy EEG biomarkers 2) leaky integrator neurons are used to build multi-timescale representations for classification. Sparse neural model firing activity is used to clock-gate device logic, thereby decreasing power consumption by 93%. An energy-optimized 1024-tree boosted decision forest performs the classification used to trigger stimulation in response to detected pathological brain states. The IC is implemented in 65nm CMOS with state-of-the-art power consumption (best case: 9.6µW, typical: 118µW), achieving a seizure sensitivity of 97.5% with a false detection rate of 2.08 per hour.

Closed-Loop Control of Functional Electrical Stimulation Using a Selectively Recording and Bidirectional Nerve Cuff Interface.

Discriminating recorded afferent neural information can provide sensory feedback for closed-loop control of functional electrical stimulation, which restores movement to paralyzed limbs. Previous work achieved state-of-the-art off-line classification of electrical activity in different neural pathways recorded by a multi-contact nerve cuff electrode, by applying deep learning to spatiotemporal neural patterns. The objective of this study was to demonstrate the feasibility of this approach in the context of closed-loop stimulation. Acute in vivo experiments were conducted on 11 Long Evans rats to demonstrate closed-loop stimulation. A 64-channel ( 8×8 ) nerve cuff electrode was implanted on each rat's sciatic nerve for recording and stimulation. A convolutional neural network (CNN) was trained with spatiotemporal signal recordings associated with 3 different states of the hindpaw (dorsiflexion, plantarflexion, and pricking of the heel). After training, firing rates were reconstructed from the classifier outputs for each of the three target classes. A rule-based closed-loop controller was implemented to produce ankle movement trajectories using neural stimulation, based on the classified nerve recordings. Closed-loop stimulation was successfully demonstrated in 6 subjects. The number of successful movement sequence trials per subject ranged from 1-17 and number of correct state transitions per trial ranged from 3-53. This work demonstrates that a CNN applied to multi-contact nerve cuff recordings can be used for closed-loop control of functional electrical stimulation.

Fascicle-Selective Ultrasound-Powered Bidirectional Wireless Peripheral Nerve Interface IC.

This paper presents an innovative, minimally invasive, battery-free, wireless, peripheral nervous system (PNS) neural interface, which seamlessly integrates a millimeter-scale, fascicle-selective integrated circuit (IC) with extraneural recording and stimulating channels. The system also incorporates a wearable interrogator equipped with integrated machine-learning capabilities. This PNS interface is specifically tailored for adaptive neuromodulation therapy, targeting individuals with paralysis, amputation, or chronic medical conditions. By employing a neural pathway classifier and temporal interference stimulation, the proposed interface achieves precise deep fascicle selectivity for recording and stimulation without the need for nerve penetration or compression. Ultrasonic energy harvesters facilitate wireless power harvesting and data reception, enhancing the usability of the system. Key circuit performance metrics encompass a 2.2 µVrms input-referred noise, 14-bit ENOB, and a 173 dB Schreier figure of merit (FOM) for the neural analog-to-digital converter (ADC). Additionally, the ultra-low-power radio-frequency (RF) transmitter boasts a remarkable 1.38 pJ/bit energy efficiency. In vivo experiments conducted on rat sciatic nerves provide compelling evidence of the interface's ability to selectively stimulate and record neural fascicles. The proposed PNS neural interface offers alternative treatment options for diagnosing and treating neurological disorders, as well as restoring or repairing neural functions, improving the quality of life for patients with neurological and sensory deficits.

Safety-Optimized Inductive Powering of Implantable Medical Devices: Tutorial and Comprehensive Design Guide.

A tutorial and comprehensive guide are presented for the design of planar spiral inductors with maximum energy delivery in biomedical implants. Rather than maximizing power transfer efficiency (PTE), the ratio of the received power to the square of the magnetic flux density is maximized in this technique. This ensures that the highest power is delivered for a given level of safe electromagnetic radiation, as measured by the specific absorption rate (SAR) in the tissue. By using quasi-static field approximations, the maximum deliverable power under SAR constraints is embedded in a lumped-element model of a 2-coil inductive link, from which planar coil geometries are derived. To compare the proposed methodology with the conventional approach that maximizes PTE, the results of both techniques are compared for three examples of state-of-the-art designs. It is demonstrated that the presented technique increases the maximum deliverable power while operating at a given level of non-ionizing radiation by factors of 8×, 410×, and 560× as compared to the three existing designs, and maintaining moderate link efficiencies of 12%, 23%, and 12%, respectively.

Síndrome de Fournier

Relato de um caso de síndrome de Fournier em paciente de sexo masculino, de 53 anos de idade. São discutidos os aspectos clínicos, etiológicos e terapêuticos