Nutritive value of fermented soybean grains for ruminants.

Fermented soybean grain (FSBG) is considered improper to use as a protein source in animal nutrition, since it is assumed that defects cause changes on its chemical composition and favor mycotoxins production, but chemical composition data does not support this theory and in vivo studies are missing. Thus, this study aimed to evaluate the effects of FSBG in feedlot lamb diets. For that, two types of FSBG (partially fermented and completely fermented, PFSBG and CFSBG) and one standard soybean grain (SSBG) were obtained and evaluated alone or as a component of experimental diets by in vitro and in vivo studies, where FSBG totally replaced SSBG in feedlot lamb diets, which was included in the experimental diets in 17.4% on dry matter basis as protein source. Before the studies, both soybeans were sent to a specialized laboratory where no mycotoxins were detected. As a result, lower DM and carbohydrate contents but higher crude protein, fiber, and indigestible NDF contents were measured in CFSBG than in SSBG. Furthermore, both types of FSBG showed lower digestibility in vitro dry matter (IVDMD) than SSBG when evaluated separately; however, when evaluated in experimental diets, the substitution of SSBG for FSBG did not affect IVDMD. It was also observed that FSBG also had less rumen-degradable protein than SSBG (mean 47.9 vs 86.4%). In the in vivo study, FSBG did not affect nutrient intake, apparent digestibility, or animal performance (i.e., average daily gain and carcass gain). Thus, mycotoxins-free FSBG may be an alternative to totally replace SSBG in feedlot lamb diets.

Brazilian version of the Pasero Opioid-Induced Sedation Scale: cross-cultural adaptation study.

OBJECTIVE: Perform a cross-cultural adaptation of the Pasero Opioid-induced Sedation Scale to the Brazilian setting. METHOD: This is a methodological study using Beaton's framework, which consists in six stages: translation, synthesis of translations, re-translation, expert committee, pre-test, and sending the adapted version of the instrument to the author of the original. The study was carried out from April to December 2021. The research was conducted in a private hospitalin the city of São Paulo, in the adult hospitalization and critical care units. It was approved by the research ethics committee. RESULTS: After translation, translation synthesis and back-translation steps, the version was evaluated by the expert committee, requiring two rounds to obtain acceptable CVI values above 0.80. In the pre-test phase, the scale was well understood, with a CVI of 0.98. CONCLUSION: The scale was adapted for the Brazilian context; however, further studies will be needed to analyze validity and reliability evidence.

Pain paths among post-COVID-19 condition subjects: A prospective cross-sectional study with in-person evaluation.

BACKGROUND: New-onset chronic pain has been acknowledged as part of the post-COVID-19 condition. However, available fine-grained data about its clinical phenotype, trajectories and main associated characteristics remain scarce. We described the distinct temporal evolutions of post-COVID-19 pain and their epidemiological and phenotypical features. METHODS: A prospective cross-sectional study enrolled post-COVID-19 condition patients (i.e. who had persisting COVID-19-related symptoms over 30 days since their first positive laboratory test), whose COVID-19 diagnosis had been supported by RT-PCR of oral/nasopharyngeal swab or serology. They underwent in-person evaluations with a structured interview, pain and quality-of-life-related questionnaires and thorough physical examination. Chronic pain (CP) and probable neuropathic pain (NP) were defined according to IASP criteria. RESULTS: The present study included 226 individuals, 177 (78.3%) of whom presented over 3 months since their first COVID-19 symptom. New-onset pain occurred in 170 (75.2%) participants and was chronic in 116 (68.2%). A chronic course was associated with COVID-19-related hospitalization, new-onset fatigue, lower cognitive performance, motor and thermal sensory deficits, mood and sleep impairments and overall lower quality-of-life levels. Probable NP occurred in only 7.6% new-onset pain patients, and was associated with pain chronification, new-onset fatigue, motor and thermal sensory deficits, mechanical allodynia and lower rates of SARS-CoV-2 vaccination. Previous CP was reported by 86 (38.1%) individuals and had aggravated after the infection in 66 (76.7%) of them, which was associated with orthostatic hypotension. CONCLUSIONS: Post-COVID pain phenomena follow different paths, which are associated with specific clinical and epidemiological features, and possibly distinct underlying mechanisms, prognostic and therapeutic implications. SIGNIFICANCE: COVID-19-related pain usually follows a chronic course and is non-neuropathic. Its possible courses and phenotypes are associated with distinct clinical and epidemiological features. This suggests differing underlying mechanisms, which may have significant prognostic and therapeutic implications.

Water masses seasonality and meteorological patterns drive the biogeochemical processes of a subtropical and urbanized watershed-bay-shelf continuum.

Understanding the different scales of temporal variability is crucial to improve the knowledge of the biogeochemical processes in the land-ocean interface. In this study, we evaluated the role of continental runoff and intrusion of oceanic water masses in the trophic state of the Bay of Santa Catarina Island (BSCI) over the last three decades (1993-2019) by using multiple biogeochemical and eutrophication assessment tools. The sub-watersheds of BSCI showed high concentrations of nutrients, fecal coliform and chlorophyll-a, directly correlated to the number of inhabitants. Worst-case scenarios were found in summer and fall seasons due to sewage inputs caused by mass tourism and the inefficiency or even absence of treatment systems, boosted by strong rainfall. The intrusion of the South Atlantic Central Water and the Plata Plume Water into the BSCI favored autotrophy in the summer and heterotrophy in the winter, coupled with low and high residence time, respectively. El Niño events enhanced rainfall and continental runoff, exporting elevated nutrients and phytoplankton biomass loads from the eutrophic rivers to the continental shelf. The pattern reverses during La Niña, when chlorophyll and nutrient peaks were detected inside the bay. Eutrophication evaluation indicated that the trophic state oscillated from moderate to high and that these conditions tend to remain the same in future scenarios due to the moderate residence time of the water, anthropogenic pressures, periodic algal blooms and the intrusion of nutrient-rich oceanic water masses. Management actions, such as the improvement of the wastewater treatment system and wetlands restoration, are needed in order to mitigate eutrophication and the loss of ecosystem services and functions.

Effects of Ultraviolet Radiation (UV-A+UV-B) on the Antioxidant Metabolism of the Red Macroalga Species Acanthophora spicifera (Rhodophyta, Ceramiales) From Different Salinity and Nutrient Conditions.

Acanthophora spicifera (M.Vahl) Børgesen is a macroalga of great economic importance. This study evaluated the antioxidant responses of two algal populations of A. spicifera adapted to different abiotic conditions when exposed to ultraviolet-A+ultraviolet-B radiation (UV-A+UV-B). Experiments were performed using the water at two collection points for 7 days of acclimatization and 7 days of exposure to UVR (3 h per day), followed by metabolic analyses. At point 1, water of 30 ± 1 practical salinity unit (psu) had concentrations of 1.06 ± 0.27 mm NH 4 + , 8.47 ± 0.01 mm NO 3 - , 0.17 ± 0.01 mm PO 4 - 3 and pH 7.88. At point 2, water of 35 ± 1 psu had concentrations of 1.13 ± 0.05 mm NH 4 + , 3.73 ± 0.01 mm NO 3 - , 0.52 ± 0.01 mm PO 4 - 3 and pH 8.55. Chlorophyll a, phycobiliproteins, carotenoids, mycosporins, polyphenolics and antioxidant enzymes (catalase, superoxide dismutase and guaiacol peroxidase) were evaluated. The present study demonstrates that ultraviolet radiation triggers antioxidant activity in the A. spicifera. However, such activation resulted in greater responses in samples of the point 1, with lower salinity and highest concentration of nutrients.

Brazilian version of the Pasero Opioid-Induced Sedation Scale: cross-cultural adaptation study / Versión brasileña de la escala Pasero Opioid-Induced Sedation Scale: estudio de adaptación transcultural / Versão brasileira da Pasero Opioid-Induced Sedation Scale: estudo de adaptação transcultural

ABSTRACT Objective: Perform a cross-cultural adaptation of the Pasero Opioid-induced Sedation Scale to the Brazilian setting. Method: This is a methodological study using Beaton's framework, which consists in six stages: translation, synthesis of translations, re-translation, expert committee, pre-test, and sending the adapted version of the instrument to the author of the original. The study was carried out from April to December 2021. The research was conducted in a private hospitalin the city of São Paulo, in the adult hospitalization and critical care units. It was approved by the research ethics committee. Results: After translation, translation synthesis and back-translation steps, the version was evaluated by the expert committee, requiring two rounds to obtain acceptable CVI values above 0.80. In the pre-test phase, the scale was well understood, with a CVI of 0.98. Conclusion: The scale was adapted for the Brazilian context; however, further studies will be needed to analyze validity and reliability evidence.

RESUMEN Objetivo: Realizar la adaptación transcultural de la escala de Pasero Opioid-induced Sedation Scale para el contexto brasileño. Método: Estudio metodológico, utilizando el marco de referencia de Beaton, que consta de seis fases: traducción, síntesis de traducciones, traducción inversa, comité de expertos, prueba previa, y envío del instrumento adaptado ala autora del instrumento original. El estudio se realizó de abril a diciembre de 2021, y a la investigación se condujo en un hospital privado, ubicado en la ciudad de São Paulo, en las unidades de hospitalización de adultos y cuidados críticos. Recibió la aprobación del comité de ética. Resultados: Después de las etapas de traducción, síntesis de traducción y traducción inversa, la versión fue evaluada por un comité de expertos, con dos rondas para obtener valores aceptables de índice de validez de contenido superiores a 0,80. En la fase previa a la prueba, la escala mostró una buena comprensión, con una puntuación de 0,98. Conclusión: La escala fue adaptada para el contexto brasileño, sin embargo, serán necesarios más estudios para analizar las evidencias de validez y confiabilidad.

RESUMO Objetivo: Realizar adaptação transcultural da escala Pasero Opioid-Induced Sedation para o cenário brasileiro. Método: Estudo metodológico, utilizado referencial de Beaton, composto por seis fases: tradução, síntese das traduções, retradução, comitê de especialistas, pré-teste e envio dos instrumentos adaptados ao autor do instrumento original. Estudo foi realizado de abril a dezembro de 2021. A pesquisa desenvolveu-se em um hospital privado, localizado no município de São Paulo, nas unidades de internação e críticas adultos. Recebeu aprovação do comitê de ética. Resultados: Após as etapas de tradução, síntese de tradução e retrotradução a versão foi avaliada pelo comitê de especialistas, com duas rodadas para obtenção de valores aceitáveis de índice de validade de conteúdo acima de 0,80. Na fase de pré-teste a escala apresentou boa compreensão com score de 0,98. Conclusão: A escala foi adaptada para o contexto brasileiro, no entanto, novos estudos serão necessários para análises de evidências de validade e confiabilidade.

Trayectorias del dolor en sujetos con afección post-COVID-19: estudio prospectivo y transversal con evaluación presencial / Pain paths among post-COVID-19 condition subjects: a prospective cross-sectional study with in-person evaluation

Antecedentes: El dolor crónico de nueva aparición se considera que forma parte de la condición o afección post-COVID-19. Sin embargo, los datos detallados existentes sobre el fenotipo clínico, las trayectorias y las principales características asociadas siguen siendo escasos. Describimos las distintas evoluciones temporales del dolor post-COVID-19 y sus rasgos epidemiológicos y fenotípicos. Métodos: Estudio prospectivo y transversal de pacientes con afección post-COVID-19 (es decir, con síntomas persistentes relacionados con la COVID-19 durante 30 días desde la primera prueba positiva de laboratorio) cuyo diagnóstico de COVID-19 estuviera basado en la RT-PCR de un frotis oral/nasofaríngeo o una serología. Se sometieron a evaluaciones presenciales mediante una entrevista estructurada, cuestionarios de dolor y calidad de vida y una exploración física exhaustiva. El dolor crónico (DC) y el dolor neuropático (DN) probablemente se definieron conforme a los criterios IASP.Resultados: El presente estudio incluyó 226 individuos, 177 (78,3 %) de los cuales se presentaron pasados más de 3 meses desde el primer síntoma de COVID-19. Tenían dolor de nueva aparición 170 (75,2 %) de los participantes y dolor crónico 116 (68,2 %). El curso crónico se asociaba a hospitalización por COVID-19, fatiga de nueva aparición, menor rendimiento cognitivo, déficits motores y sensitivos térmicos, alteraciones del ánimo y el sueño, y niveles generalmente inferiores de calidad de vida. El DN probable afectaba a solo el 7,6 % de los pacientes con dolor de nueva aparición y se asociaba a cronificación del dolor, fatiga de nueva aparición, déficits motores y de sensación térmica, alodinia mecánica y tasas menores de vacunación frente al SARS-CoV-2. Referían DC previo 86 (38,1 %) individuos, y este había empeorado tras la infección en 66 (76,7 %) de ellos, lo que se asociaba a hipotensión ortostática...(AU)

Background: New-onset chronic pain has been acknowledged as part of the post-COVID-19 condition. However, available fine-grained data about its clinical phenotype, trajectories and main associated characteristics remain scarce. We described the distinct temporal evolutions of post-COVID-19 pain and their epidemiological and phenotypical features.Methods: A prospective cross-sectional study enrolled post-COVID-19 condition patients (i.e. who had persisting COVID-19-related symptoms over 30 days since their first positive laboratory test), whose COVID-19 diagnosis had been supported by RT-PCR of oral/nasopharyngeal swab or serology. They underwent in-person evaluations with a structured interview, pain and quality-of-life-related questionnaires and thorough physical examination. Chronic pain (CP) and probable neuropathic pain (NP) were defined according to IASP criteria.Results: The present study included 226 individuals, 177 (78.3 %) of whom presented over 3 months since their first COVID-19 symptom. Newonset pain occurred in 170 (75.2 %) participants and was chronic in 116 (68.2 %). A chronic course was associated with COVID-19-related hospitalization, new-onset fatigue, lower cognitive performance, motor and thermal sensory deficits, mood and sleep impairments and overall lower quality-of-life levels. Probable NP occurred in only 7.6 % new-onset pain patients, and was associated with pain chronification, new-onset fatigue, motor and thermal sensory deficits, mechanical allodynia and lower rates of SARSCoV-2 vaccination. Previous CP was reported by 86 (38.1 %) individuals and had aggravated after the infection in 66 (76.7 %) of them, which was associated with orthostatic hypotension.Conclusions: Post-COVID pain phenomena follow different paths, which are associated with specific clinical and epidemiological features, and possibly distinct underlying mechanisms, prognostic and therapeutic implications...(AU)

[Discrepancy between IGF-1 and GH during 75 g oral glucose tolerance test measures to acromegaly screening in a patient with macroprolactinoma--case report and literature review]. / Discordância entre IGF-1 e GH pós-sobrecarga de glicose no rastreamento de acromegalia em paciente com macroprolactinoma--relato de caso e revisão sobre o tema.

We describe a patient with macroprolactinoma and discrepant insulin-like growth factor (IGF-1) concentration (elevated) and growth hormone (GH) values during a 75 g oral glucose tolerance test (normal), that were measured to evaluate the co-secretion of GH by tumor. With the bromocriptin use, the patient achieved normalization of prolactin, but persisted with high levels of IGF1, suggesting to be subclinical acromegaly. After the development of new more sensitive GH assays, cases of discrepant GH and IGF-1 results have been observed and taken to some authors to suggest that GH nadir concentration during 75 g OGTT used to acromegaly diagnosis and treatment could be lower than values considered currently normal. Thus, if this is confirmed, subclinical and oligosymptomatic acromegaly cases could have earlier diagnoses.

[Cerebral calcifications due to hypoparathyroidism: considerations about cases diagnosed many years after partial thyroidectomy]. / Calcificações cerebrais por hipoparatireoidismo: considerações sobre o diagnóstico, longo tempo após a tireoidectomia.

The diagnosis of hypoparathyroidism with neurological findings occurring years after thyroid surgery is considered to be rare. The authors describe 3 cases of hypoparathyroidism associated to brain calcifications diagnosed many years after partial thyroidectomy. Two patients were admitted to Emergency Services presenting with seizures, without a previous diagnosis of hypoparathyroidism. The diagnosis was suspected adding the biochemical analysis to the scar on the neck. The CT, which was performed more than 20 years after surgery, showed large cerebral calcifications in both cases. The third patient did not have neurological symptoms, but presented basal and cerebellar calcifications that were demonstrated in the CT. All patients were treated with calcium and vitamin D with great improvement of clinical status. Adding to a case published previously, we count 4 cases from the same region. Thyroidectomies were very common in this region poor in dietary iodide. Since the clinical follow up was inadequate, we suspect that undetected cases similar to these may exist in the present moment.

Phosphorus dynamics in water and sediments in urbanized and non-urbanized rivers in Southern Brazil.

Phosphorus flux models show that the removal tends to be a common feature in polluted estuarine systems whereas the release of P to the adjacent coastal area occurs in pristine environments. This study analyzes the distribution of P in water and sediments along six rivers in the south coast of Brazil. Three rivers located inside protected areas were considered non-polluted and used as a control of urbanization. The other three, situated within urbanized areas, were considered as having highly elevated concentrations of P. Results showed a different behavior of P in water and sediments located in urbanized and non-urbanized areas. The concentrations of dissolved organic (P-org) and inorganic (P-inorg) phosphorus in water, and the total phosphorus (P-tot) and polyphosphate (P-poly) in sediments where higher in the urbanized rivers compared to the non-urbanized ones. Both P of punctual origin and of diffuse origin contributed to the maintenance of elevated concentrations and disturbed the natural fluxes along the polluted rivers. The minimum and maximum concentrations in urbanized areas varied from 0.39 to 12.45 (microM) for P-org and 0.00 to 5.92 (microM) for P-inorg in water, and in sediments from 89.90 to 808.16 (microM g(-1)) for P-tot and 0.00 to 76.51 (microM g(-1)) for P-poly. In non-urbanized areas concentrations in water varied from 0.22 to 1.20 (microM) for P-inorg and 4.43 to 5.56 (microM) for P-org, and in sediments from 45.91 to 652.26 (microM g(-1)) for P-tot and 0.00 to 8.61 (microM g(-1)) for P-poly. Using a hierarchical sampling design and a simple model of variation of P (K(d) model) it was possible to demonstrate that urbanized and non-urbanized estuaries may act as sinks or sources of P. The variation of P analysis in different points along each of the six rivers showed that release and removal areas may occur within a same river independently of its urbanization.

Evaluation of reaction factors for deposition of silica (SiO2) nanoparticles on cellulose fibers.

This study aimed to evaluate reaction conditions for deposition of SiO2 nanoparticles on the surface of cellulose fibers and their influence on moisture adsorption of the hybrid organic-inorganic material formed. SiO2 nanoparticle deposition was carried out with the sol-gel process testing four reaction times (2, 12, 18, and 24h) and three contents of the tetraethyl-orthosilicate (TEOS) precursor (1.9, 4.2 and 8.4g g(-1) of cellulose fiber). Modification time and TEOS content directly influence the amount of Si deposited on the fiber surface, nanoparticle diameter distribution, thermal stability, and resistance to moisture adsorption. There is a tendency of slight increase of nanoparticle size and the amount of Si deposited with increasing reaction time. SiO2 nanoparticles were bonded on the surface of the cellulose fibers and are able to improve thermal stability of the material, increasing onset degradation temperature. The moisture adsorption capacity of the modified cellulose fiber was reduced up to 50%.

The impact of coastal urbanization on the structure of phytobenthic communities in southern Brazil.

The anthropogenic pressures on coastal areas represent important factors affecting local, regional, and even global patterns of distribution and abundance of benthic organisms. This report undertakes a comparative analysis of the community structure of rocky shore intertidal phytobenthos in both pristine like environments (PLE) and urbanized environments (UBE) in southern Brazil, characterizing variations on different spatial scales. Multivariate analysis of variance indicated that the PLE is characterized by a larger number of taxa and an increased occurrence of Rhodophyta species in relation to UBE. In contrast, UBE were dominated by opportunistic algae, such as Cladophora and Ulva spp. Significance tests further indicated higher species richness and Shannon-Wiener diversity on the PLE in relation to UBE. Here we provide data showing the magnitude of seaweed biodiversity loss and discuss direct and indirect consequences of unplanned urbanization on these communities.

Carga interna de treinamento em diferentes aulas pré formatadas do sistema Les Mills® / Internal training load in different pre standardized workouts of Les Mills® system

O objetivo do presente estudo foi quantificar a carga interna de treinamento imposta em diferentes aulas pré-formatadas do sistema Les Mills® e comparar a percepção de esforço planejada pelo instrutor com a percebida pelas alunas. A amostra foi constituída por 20 mulheres jovens. Foram monitoradas 10 aulas, em duas semanas consecutivas. A carga interna foi determinada pelo método da percepção subjetiva do esforço da sessão (PSE-sessão). Os valores da PSE-sessão não diferiram significativamente da 1ª para a 2ª semana (Body Combat© = 252 ± 36 vs. 258 ± 39 UA – p=0,64; Body Pump© (terça-feira) = 171 ± 35 vs. 177 ± 30 UA – p=0,33; Body Step© = 246 ± 51 vs. 252 ± 46 UA– p=0,43; Body Pump© (quinta-feira) = 183 ± 30 vs. 225 ± 38 UA– p=0,06; Power Jump© = 291 ± 44 vs. 315 ± 42 UA– p=0,06). Houve diferença em 50% das aulas no tocante à intensidade planejada pelo instrutor e a experimentada pelas alunas: Body Combat© (Instrutor: 3 vs. Alunas: 4,2 ± 0,6 – p<0,01), Body Pump© (terça-feira) (Instrutor: 2 vs. Alunas: 2,8 ± 0,6 – p<0,01) e Power Jump© (Instrutor: 6 vs. Alunas: 4,8 ± 0,7 – p<0,01) ministradas na 1ª semana e nas aulas de Body Step© (Instrutor: 5 vs. Alunas: 4,2 ± 0,7 – p<0,01) e Power Jump© (Instrutor: 6 vs. Alunas: 5,2 ± 0,5 – p<0,01) ministradas na 2ª semana. Os resultados sugerem que as aulas analisadas mantiveram o mesmo padrão de carga interna quando repetidas em semanas distintas. Entretanto, houve discrepância entre a intensidade planejada pelo instrutor e a experimentada pelas alunas. Estes resultados apontam a importância do monitoramento das cargas de treinamento em aulas pré-formatadas, especialmente no contexto do fitness.

The aim of this study was to quantify internal training loadimposed on different pre-formatted classes Les Mills® system and compare the perception ofeffort planned by the instructor with perceived by the students. The sample consisted of 20young women. 10 lessons were monitored for two consecutive weeks. The internal loadwas determined by the perceived exertion of the session (session-PSE) method. thevalues of PSE-session did not differ significantly from the 1st to 2nd week (Body Combat ©= 252 ± 36 vs. UA 258 ± 39 - p = 0.64; © Body Pump (Tuesday) = 171 ± 35 vs. 177 ± 30AU - p = 0.33; Body Step © = 246 ± 51 vs. UA- 252 ± 46 p = 0.43; © Body Pump (Thursday)= 183 ± 30 vs. 225 ± 38 UA- p = 0.06; Power Jump © = 291 ± 44 vs. UA- 315 ± 42 p = 0.06).Was no difference in 50% of lessons regarding the intensity planned by the instructor and theexperienced by the students: Body Combat © (Instructor: Students vs. 3: 4.2 ± 0.6 - p <0.01), Body© Pump (Tuesday) (Instructor: Students vs. 2: 2.8 ± 0.6 - p <0.01) and Power Jump © (Instructor: 6vs. Students: 4.8 ± 0.7 - p <0.01) in the 1st week and taught classes in Body Step © (Instructor:5 vs. Students: 4.2 ± 0.7 - p <0.01) and Power Jump © (Instructor: Students vs. 6: 5.2 ± 0.5 - p <0.01)held in the 2nd week. The results suggest that the classes analyzed maintained the samestandard internal load when repeated in different weeks. However, there was a discrepancybetween the intensity planned by the instructor and experienced by the students. these resultsindicate the importance of monitoring training loads at pre-formatted classes,especially in the context of fitness.

Efeito da caminhada sobre a qualidade de vida e auto-eficácia de mulheres com síndrome da fibromialgia / Effect of practical of walk on the quality life and self- efficacy of women with fibromyalgia syndrome

Verificar o efeito da prática de 10 sessões de caminhada sobre a qualidade de vida e auto-eficácia de mulheres com Síndrome da Fibromialgia (FM). Método: Participaram do estudo oito mulheres com diagnóstico clínico de FM, selecionadas de forma não-probabilística intencional. As avaliações foram realizadas antes e após 10 sessões da prática de caminhada. Os instrumentos utilizados foram o Questionário Sócio-demográfico e Clínico, o Questionário de Impacto da Fibromialgia e a Escalade Auto-eficácia para Dor Crônica. Após a verificação da normalidade através do teste Shapiro-Wilk, osdados foram tratados com estatística descritiva (freqüência, média e desvio padrão) e inferencial (teste t de Student e teste de Pearson). Resultados: A média de idade das participantes foi de 49 anos (+12,8), o impacto da síndrome da fibromialgia na qualidade de vida no pré-teste foi de 53,64 pontos e no pós-teste de 51,99 pontos (p=0,73) e a Auto-eficácia no pré-teste foi de 147,57 pontos e no pós-teste foi de 172,27 pontos (p=0,15). Em relação aos três domínios deste questionário, apenas o domínio da Auto-eficácia para lidar com outros sintomas apresentou diferença significativa entre o pré e pós-teste (p=0,02). Houve correlação negativa pós-teste (r=-0,72; p=0,042) entre o impacto da fibromialgia e a auto-eficácia. Conclusão: Apesar do curto período de intervenção realizado, a prática de caminhada melhorou o domínio da auto-eficácia para lidar com outros sintomas em mulheres com FM. Em relação à qualidade de vida, não ocorreram melhoras.

Objective: Verify the effect of practical of 10 walk sessions on the quality life and self efficacy of women with Fibromyalgia Syndrome (FM). Method: eight women with clinical diagnosis of FM had participated of the study. The evaluations were before and after 10 sessions of the practical of walking. The used instruments were the “Questionário Sócio-Demográfico e Clínico”, “The Fibromyalgia Impact Questionnaire”, and the “Chronic Pain Self-efficacy Scale”. After the verification of normality through the Shapiro-Wilk test, the data were dealt with descriptive statistics (frequency, average and deviation standard), test t and Pearson. Results: The average of age of the participants was of 49 years (±12,8), the impact of the fibromyalgia syndrome in the quality of life in the daily pay-test was of 53,64 points and in the after-test of 51,99 points (p=0,73) and the self-efficacy in the daily pay-test was of 147,57 points and in the after test was of 172,27 points (p=0,15). In respect to the three domains of this questionnaire, only the domain of the self-efficacy to deal with other symptoms presented significant difference between the daily pay and after-test (p=0,02). After test had negative correlation (r=-0,72; p=0,042) on the impact of the fibromyalgia and self-efficacy. Conclusion: Although the small number of accomplished sessions (10 sessions), the practical of walking improved the domain of the self-efficacy to deal with other symptoms in women with FM. In the analysis of the quality of life, had not occurred improvements.

Evaluation of impacts of climate change and local stressors on the biotechnological potential of marine macroalgae: a brief theoretical discussion of likely scenarios

Climate change can be associated with variations in the frequency and intensity of extreme temperatures and precipitation events on the local and regional scales. Along coastal areas, flooding associated with increased occupation has seriously impacted products and services generated by marine life, in particular the biotechnological potential that macroalgae hold. Therefore, this paper analyzes the available information on the taxonomy, ecology and physiology of macroalgae and discusses the impacts of climate change and local stress on the biotechnological potential of Brazilian macroalgae. Based on data compiled from a series of floristic and ecological works, we note the disappearance in some Brazilian regions of major groups of biotechnological interest. In some cases, the introduction of exotic species has been documented, as well as expansion of the distribution range of economically important species. We also verify an increase in the similarities between the Brazilian phycogeographic provinces, although they still remain different. It is possible that these changes have resulted from the warming of South Atlantic water, as observed for its surface in southeastern Brazilian, mainly during the winter. However, unplanned urbanization of coastal areas can also produce similar biodiversity losses, which requires efforts to generate long-term temporal data on the composition, community structure and physiology of macroalgae.

Fatores associados à adesão e desistência ao exercício físico de pacientes com fibromialgia: uma revisão / Factors of adhesion and abandonment to exercise of patients with fibromyalgia: a review

O tratamento proposto atualmente aos pacientes com Fibromialgia (FM) baseia-se na tríade exercício físico, apoio psicológico e terapia medicamentosa. Porém, muito tem sido evidenciado com relação à baixa adesão desses pacientes ao exercício físico. Dessa forma, este estudo teve como objetivo revisar a literatura sobre motivos de adesão e desistência ao exercício físico de pacientes com FM e sobre estratégias de intervenção propostas. Para isso foi realizada uma revisão da literatura de artigos científicos publicados entre os anos de 1990 a 2010 com as palavras-chave exercício, adesão, desistência, fibromialgia. Os estudos demonstraram que os principais fatores de adesão ao exercício físico por pacientes com FM foram ter baixos níveis de depressão, menor faixa etária, maior grau de escolaridade, alta percepção de auto-eficácia e bom convívio social. Os principais fatores relacionados à desistência foram intolerância a exercícios de alta intensidade e altos níveis de dor nas pacientes com FM. As estratégias de intervenção para a adesão ao exercício identificadas nos estudos revistos foram a educação sobre importância dos exercícios físicos, ter uma equipe multidisciplinar nos programas de tratamento, ter um bom vínculo terapeuta-paciente e prescrição do exercício por escrito e individualizada.

The Fibromyalgia (FM) treatment is based on a triad that involves physical exercise, psychology and medication. However, a low adhesion to physical exercise has been indicated. Thus, the aim of the study was to review the literature over adhesion and abandonment of physical exercise of FM patients and over intervention strategies. For so, a literature review was performed over articles published between 1990 and 2010, looking with the key-words exercise, adhesion, abandonment, fibromyalgia. Researches shown that the major factors of physical exercise adhesion of FM patients were: low levels of depression, lower age, higher education level, high perception of self-efficacy and good social life. The factors related to abandonment were described as intolerance to high intensity of physical exercise and high levels of pain. The intervention strategies proposed for adhesion to exercise identified in the studies reviewed were education on the importance of exercise, multidisciplinarity on treatment programs, have a good therapist-patient relationship and exercise prescription written and individualized.

Perfil de humor de mulheres com fibromialgia / Profile's mood in women with fibromyalgia

OBJETIVO: O objetivo deste estudo foi verificar o perfil dos estados de humor de mulheres com fibromialgia, bem como analisar sua associação com características sociodemográficas e clínicas. MÉTODOS: Cento e seis participantes responderam ao Questionário Sociodemográfico e Clínico (QSDC) e à Escala de Humor de Brunel (BRUMS). O QSDC é constituído por perguntas sobre dados pessoais e aspectos clínicos, enquanto o BRUMS avalia o humor por meio de seis fatores, a saber: tensão, depressão, raiva, vigor, fadiga e confusão mental. Os dados foram tratados com estatística descritiva e por meio dos testes de Kruskal-Wallis e Mann-Whitney. RESULTADOS: As variáveis negativas do humor estiveram em níveis elevados, em especial a tensão, a depressão, a fadiga e a confusão mental, enquanto o vigor esteve baixo. Verificou-se ainda que as participantes mais jovens que trabalham com diagnóstico de depressão e, principalmente, as que possuíam maior número de sintomas relacionados à fibromialgia apresentavam humor mais deprimido do que seus pares. CONCLUSÃO: Mulheres com fibromialgia apresentaram tendência de humor deprimido, sendo que essa característica se apresentou associada a fatores sociodemográficos e clínicos.

OBJECTIVE: The aim of this study was to verify the association between mood states with clinical and sociodemographic characteristics of women with fibromyalgia. METHODS: One hundred six participants answered the Sociodemographic and Clinical Questionnaire (QSDC) and the Brunel Mood Scale (BRUMS). The QSDC is composed of questions about personal and clinical aspects, while BRUMS evaluates mood state over six components: tension, depression, anger, vigor, fatigue and mental confusion. Data was treated with descriptive statistics and the Kruskal-Wallis and Mann-Whitney test. RESULTS: The negative mood variables whore elevated, especially the tension, depression, fatigue and mental confusion, while the vigor was considered in low-level. It was also found that younger participants, who work, with a diagnosis of depression and particularly those having increased symptoms related to fibromyalgia had more depressed mood than their peers. CONCLUSION: Women with fibromyalgia had a trend toward depressed mood, and this feature is presented associated with sociodemographic and clinical factors.

Acidentes ocupacionais: conhecimento, atitudes e experiências de estudantes de odontologia da Universidade Federal da Paraíba / Occupational hazards: knowledge, attitude and experience of undergraduate dental students of the Federal University of Paraiba, Brazil

Objetivo: Identificar a ocorrência de acidentes ocupacionais em alunos de graduação da Universidade Federal da Paraíba e analisar o conhecimento destes sobre a conduta a ser adotada.Método: Utilizou-se abordagem indutiva, com procedimento estatístico-descritivo e técnica de observação direta extensiva, por meio de questionário. A amostra foi de 168 alunos (83,6%) do Curso de Odontologia regularmente matriculados do 5º ao 10º período. Realizou-se previamente um estudo piloto com 20 alunos para garantir a validade do instrumento da pesquisa.Resultados: Observou-se que 100 (59,5%) estudantes relataram ter sofrido acidente ocupacional, existindo predomínio do gênero masculino (62%) e dos estudantes do 8º ao 10º períodos. Os acidentes superficiais foram citados por 101 acadêmicos e os percutâneos por 29, sendo a distração (24,2%), a pressa (18,9%) e a pouca experiência (15,4%) as principais causas relatadas. A agulha anestésica (19,4%) e a sonda exploradora nº5 (16,4%); a dentística (28,5%) e a cirurgia (25,1%) foram os instrumentos e clínicas mais citados, respectivamente. Aproximadamente 60% dos acidentes ocorreram durante a lavagem dos instrumentais. O uso incompleto do EPI foi observado em 80 estudantes (80%) que sofreram acidentes, enquanto o uso completo em 73,5% dos que nunca sofreram acidentes. Dos estudantes que obtiveram conhecimento prévio sobre como proceder em caso de acidentes, 90 (56,8%) responderam corretamente. Um percentual de 65,5% e 22% dos estudantes possuem imunização completa para hepatite B e tétano, respectivamente.Conclusão: A experiência com acidentes ocupacionais aumenta à medida que os acadêmicos evoluem no curso, sendo o cuidado com a biossegurança e a imunização deficientes. Os pontos críticos encontrados foram: negligência nas condutas mediatas pós-acidente, lavagem do instrumental, ausência de luvas de borracha e imunização incompleta.

Discordância entre IGF-1 e GH pós-sobrecarga de glicose no rastreamento de acromegalia em paciente com macroprolactinoma: relato de caso e revisão sobre o tema / Discrepancy between IGF-1 and GH during 75 g oral glucose tolerance test measures to acromegaly screening in a patient with macroprolactinoma: case report and literature review

Neste artigo, descrevemos o caso de um paciente com diagnóstico de macroprolactinoma, que apresentava valores discordantes entre IGF-1 (elevado) e GH (hormônio de crescimento) pós-teste de tolerância oral à glicose (normal) realizados para pesquisa de co-secreção de GH pelo tumor. Houve normalização dos níveis de prolactina após uso de bromocriptina, porém, durante o acompanhamento, o paciente persistiu com níveis elevados de IGF-1 sem clínica aparente, sugerindo tratar-se de possível forma subclínica de acromegalia. Após o desenvolvimento de novos métodos laboratoriais, mais sensíveis, para a dosagem de GH, casos de discordância entre esses testes vêm sendo observados, levando alguns autores a sugerir que o nadir de GH pós-teste de tolerância à glicose oral (TTGO) para diagnóstico e tratamento da acromegalia pode ser bem menor do que o limite considerado atualmente (1,2). Assim, se isto for confirmado, casos subclínicos ou oligossintomáticos de acromegalia serão diagnosticados mais precocemente.

We describe a patient with macroprolactinoma and discrepant insulin-like growth factor (IGF-1) concentration (elevated) and growth hormone (GH) values during a 75 g oral glucose tolerance test (normal), that were measured to evaluate the co-secretion of GH by tumor. With the bromocriptin use, the patient achieved normalization of prolactin, but persisted with high levels of IGF1, suggesting to be subclinical acromegaly. After the development of new more sensitive GH assays, cases of discrepant GH and IGF-1 results have been observed and taken to some authors to suggest that GH nadir concentration during 75 g OGTT used to acromegaly diagnosis and treatment could be lower than values considered currently normal. Thus, if this is confirmed, subclinical and oligosymptomatic acromegaly cases could have earlier diagnoses.