Somatic profile in lung cancers is associated to reproductive factors in never-smokers women: Results from the IFCT-1002 BioCAST study.

BACKGROUND: Lung cancer in women is on the rise, with a higher proportion occurring in lifelong never-smokers. Lung cancer in never-smokers (LCINS) exhibits a high frequency of driver oncogene alterations. In this study, we aimed to investigate whether exposure to reproductive factors in women with LCINS may modulate the molecular pattern. METHODS: All newly diagnosed LCINSs were included in a prospective, observational study (IFCT-1002 BioCAST). Each patient responded to a questionnaire including reproductive factors. Biomarker test results were also collected. RESULTS: Two hundred and sixty women were included in this analysis, and 166 alterations were characterized. EGFR mutation frequency proved greater among patients with late menarche (74% in age>14 vs. 40% and 41% for 12-14 and ≤12 years, respectively; P=0.020) and tended to decrease with increasingly late age at menopause. In multivariate analysis, EGFR mutation frequency increased by 23% per increment of 1 year of age at menarche (P=0.048), and by 9% for each year at age at first birth (P=0.035). ALK alteration frequency was greater in women with high parity (50% in≥5 vs. 12% and 7% for 1-4 and nulliparity, respectively; P=0.021). CONCLUSION: In a cohort of women LCINSs, female hormonal factors appear to impact molecular pattern.

[Predictive factors of complications during CT-guided transthoracic biopsy]. / Facteurs prédictifs de complications des ponctions transpariétales thoraciques.

INTRODUCTION: CT-guided transthoracic core-needle biopsy (TTNB) is frequently used for the diagnosis of lung nodules. The aim of this study is to describe TTNBs' complications and to investigate predictive factors of complications. METHODS: All consecutive TTNBs performed in three centers between 2006 and 2012 were included. Binary logistic regression was used for multivariate analysis. RESULTS: Overall, 970 TTNBs were performed in 929 patients. The complication rate was 34% (life-threatening complication in 6%). The most frequent complications were pneumothorax (29% included 4% which required chest-tube) and hemoptysis (5%). The mortality rate was 0.1% (n=1). In multivariate analysis, predictive factor for a complication was small target size (AOR=0.984; 95% CI [0.976-0.992]; P<0.001). This predictive factor was also found for occurrence of life-threatening complication (AOR=0.982; [0.965-0.999]; P=0.037), of pneumothorax (AOR=0.987; [0.978-0.995]; P=0.002) and of hemoptysis (AOR=0.973; [0.951-0.997]; P=0.024). CONCLUSION: One complication occurred in one-third of TTNBs. The proportion of life-threatening complication was 6%. A small lesion size was predictive of complication occurrence.

[Lung function in patients with diabetes mellitus]. / Fonction pulmonaire du patient diabétique.

INTRODUCTION: Diabetes mellitus is a disease affecting a lot of organs. One of the little known diabetes complication is impairment of pulmonary function. The aim of this study was to compare pulmonary function in two groups: diabetic individuals and obese non-diabetic individuals and to investigate predictive factors of alteration of diffusing capacity of lung for carbon monoxide (DLCO). PATIENTS AND METHOD: We retrospectively included all patients hospitalized in department of endocrinology between 1st July 2013 and 31 December 2013 and who underwent pulmonary function tests. All these medical charts of patients were reviewed and patients were classified in two groups: diabetic and obese non-diabetic individuals. RESULTS: Overall, 89 patients were included, 62 diabetic patients and 27 obese non-diabetic patients. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), medium expiratory flow, expiratory residual volume, total lung capacity (TLC) and DLCO were significantly lower in patients with diabetes mellitus compared to obese non-diabetic patients. A low DLCO was significantly associated with diabetic neuropathy, macrovascular complication (carotid atheroma), impairment of renal function, and insulin treatment. CONCLUSION: Respiratory function is impaired in diabetes mellitus, with a significant decrease in FVC, FEV1, TLC and DLCO.