ABSTRACT
The COVID-19 pandemic represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge on pathophysiological mechanisms of neuropsychiatric diseases. One of these opportunities is the study of the relationships between inflammation, brain development and an increased risk of suffering neuropsychiatric disorders. Based on the hypothesis that neuroinflammation during early stages of life is associated with neurodevelopmental disorders and confers a greater risk of developing neuropsychiatric disorders, we propose a cohort study of SARS-CoV-2-infected pregnant women and their newborns. The main objective of SIGNATURE project is to explore how the presence of prenatal SARS-CoV-2 infection and other non-infectious stressors generates an abnormal inflammatory activity in the newborn. The cohort of women during the COVID-19 pandemic will be psychological and biological monitored during their pregnancy, delivery, childbirth and postpartum. The biological information of the umbilical cord (foetus blood) and peripheral blood from the mother will be obtained after childbirth. These samples and the clinical characterisation of the cohort of mothers and newborns, are tremendously valuable at this time. This is a protocol report and no analyses have been conducted yet, being currently at, our study is in the recruitment process step. At the time of this publication, we have identified 1,060 SARS-CoV-2 infected mothers and all have already given birth. From the total of identified mothers, we have recruited 537 SARS-COV-2 infected women and all of them have completed the mental health assessment during pregnancy. We have collected biological samples from 119 mothers and babies. Additionally, we have recruited 390 non-infected pregnant women.
ABSTRACT
OBJETIVOS: conocer los factores relacionados con el incremento de la infertilidad, así como las causas y criterios de derivación delas parejas estériles y revisar el proceso de las diferentes alternativas terapéuticas que se pueden proponer fruto de las nuevas tecnologías. MÉTODO: revisión narrativa en la que se realiza una búsqueda bibliográfica en las bases de datos Cochrane, Medline y Cuiden y consulta en páginas de sociedades científicas. El criterio de selección se limitó a artículos originales y revisiones en los últimos 15años, con texto disponible en abstracto a texto completo, en español y en inglés. RESULTADOS Y CONCLUSIONES: se recuperaron un total 56 referencias, de las cuales se seleccionaron 19. Del análisis de los 19artículos y documentos seleccionados se generaron tres categorías principales: factores relacionados con la infertilidad, causas de infertilidad y tratamientos de la misma. El retraso del deseo reproductivo y el estilo de vida explican un posible incremento delos problemas de infertilidad, siendo la causa única o múltiple. Para su tratamiento, la elección de una técnica u otra (inseminación artificial, fecundación in vitro y donación de ovocitos) varía en función de la etiología de la esterilidad. En España se estima que casi un 15% de las parejas tienen problemas de esterilidad. La velocidad a la que evolucionan las técnicas de reproducción humana asistida y los tratamientos de infertilidad ponen en relieve la necesidad de formación constante de los profesionales relacionados con la reproducción
OBJECTIVES: to understand those factors associated with an increase in infertility, as well as the causes and referral criteria for infertile couples and to review the process of different therapeutic alternatives which can be offered, as a result of new technologies. METHOD: narrative review involving a bibliographic research in the Cochrane, Medline and Cuiden databases, and a search in webpages by scientific societies. The selection criteria was limited to original articles and reviews within the past 15 years, with text available as abstract or full text, in Spanish and in English. RESULTS AND CONCLUSIONS: in total, 56 references were collected,and 19 of these were selected. From the analysis of these selected19 articles and documents, three main categories were generated: factors associated with infertility, causes of infertility, and treatments for this condition. The delay of the reproductive desire, as well as lifestyle, can explain a possible increase in infertility problems, which may have a single cause, or multiple causes. For treatment, the selection of a technique over another (artificial insemination, in vitro fecundation, and ovocyte donation) varies according to the etiology of sterility. It is estimated that almost15% of couples in Spain have sterility problems. The fast rate of evolution of assisted human reproduction and infertility treatments highlight the need for constant training targeting those professionals associated with reproduction