Bistable Aryl Azopyrazolium Ionic Photoswitches in Water.

We report a new class of arylazopyrazolium-based ionic photoswitches (AAPIPs). These AAPIPs with different counter ions have been accessed through a modular synthetic approach in high yields. More importantly, the AAPIPs exhibit excellent reversible photoswitching and exceptional thermal stability in water. The effects of solvents, counter ions, substitutions, concentration, pH, and glutathione (GSH) have been evaluated using spectroscopic investigations. The results revealed that the bistability of studied AAPIPs is robust and near quantitative. The thermal half-life of Z isomers is extremely high in water (up to years), and it can be lowered electronically by the electron-withdrawing groups or highly basic pH.

Photoswitchable Azoheteroarene-Based Chelating Ligands: Light Modulation of Properties, Aqueous Solubility and Catalysis.

We report the design and synthesis of eight photoswitchable phenylazopyridine- and phenylazopyrazole-based molecular systems as chelation-type light-controllable ligands. Besides the studies on fundamental photoisomerization behaviour, the ligands were also screened for light-tuneable properties such as photochromism, phase transition, and solubility, especially in the aqueous medium. This investigation demonstrates how the modulation of aqueous solubility can be achieved through photoisomerization and can further be utilized towards controlling the amount of catalytically active Cu(I) species in the aqueous conditions. Through this approach, light control over the catalytic activity was achieved for Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, along with a partial recovery of the catalytically active species.

Structure-Property Relationship for Visible Light Bidirectional Photoswitchable Azoheteroarenes and Thermal Stability of Z-Isomers.

A modular approach has been adopted to synthesize a wide range of visible light-driven photoswitchable azoheteroarenes. In this regard, we considered ortho substitution of cyclic amines in the aryl ring and varied substitution patterns. Using detailed spectroscopic studies, we established a relationship between structure and photoswitching ability and also half-lives of the Z-isomers. Through this, we envision tunable and bidirectional longer wavelength photoswitches.

Tuning of Bistability, Thermal Stability of the Metastable States, and Application Prospects in the C3 -Symmetric Designs of Multiple Azo(hetero)arenes Systems.

Light-responsive molecular systems with multiple photoswitches in C3 -symmetric designs have enormous application potential. The design part of such molecular systems is critical due to its influence in several properties associated with the photoswitches. In order to tune, and in the evaluation of the design-property relationship, we synthesized 18 tripodal systems with variations in the core, linkers, connectivity, and azo(hetero)arene photoswitches. Through extensive spectroscopic and computational studies, we envisaged the factors controlling near-quantitative photoisomerization in both the directions (bistability) and the thermal stability of the metastable states. Furthermore, we also evaluated the impact of designs in obtaining reversible photo-responsive sol-gel phase transitions, solvatochromism, photo- and thermochromism.