Immunohistochemical and morphological characteristics of tissues response to polylactic acid membranes with silver nanoparticles.

BACKGROUND: The aim of this research was to study anti-microbial and anti-inflammatory characteristics of silver nanoparticles helping bone structures to recover during late stage of parodontitis, which afterwards will increase the effect of bone regeneration operations. MATERIALS AND METHODS: We assessed colloid solution-derived silver nanoparticles coating of polylactic acid membrane regarding tissue foreign body response. Thirty eight polylactic acid membranes were implanted intracranially in rabbits - ten unmodified (control group) and twenty eight with silver nanoparticles coating (experimental group). In controls, penicillin was used for infection prophylaxis. Tissue response was assessed by light microscopy and immunohistochemistry (CD3, CD15, CD30) 2 weeks after implantation. RESULTS: inflammation markers in experimental group were significantly lower than in control group, there were no signs of forming a fibrosis capsule nor infectious signs. CONCLUSIONS: colloid silver solution can be used as a source of nanoparticles for anti-microbial and anti-inflammatory biodegradable membranes' coating.

[The Medical Social Aspects of Health and Satisfaction of Parents with Medical Care of Children with Oncologic Diseases].

The article presents analysis of social economic health determinants of parents of children with oncologic diseases. The evaluation of their satisfaction with accessibility of qualitative medical care was carried out. The questionnaire covered issues concerning medical social aspects of health and satisfaction with quality of medical care. the sampling included 284 parents of children with oncologic diseases receiving treatment in the profile departments of Krasnodar, Stavropol, Volgograd, Makhachkala, Grozny, Cherkessk, Nalchik and Astrakhan in August-September 2015. The parents answered to questionnaire independently. The filled questionnaires handed over to the responsible physician. The responsible physician was fully instructed how to proceed with survey. The study established that oncologic disease of child effects quality of life of parents in 33.2% of cases. The relationships within family deteriorate in 19.7% of cases. According opinion of parents, they have high level of literacy in health issues. Only every second parent trusts official medicine and certain percentage of respondents resorts to non-traditional care including psychic individuals and priests. The analysis of answers permitted to derive that hospitalization provides no difficulties though dissatisfaction with treatment costs and attitude of medical personnel remains.It is established that parents of children with oncologic diseases suffer from anxiety and depression on clinical and sub-clinical level that requires implementation of complex of measures of psychological support. The direct dependence is established concerning between presence of anxiety and depression and also presence of depression and physical indisposition of respondents.