ABSTRACT
A double-blind, comparative study between urea ointment and a placebo ointment (the urea vehicle) in the treatment of industrial acne is presented herein. The possible reasons as to why both treatments presented equally favorable results are discussed.
Subject(s)
Acne Vulgaris/drug therapy , Dermatitis, Occupational/drug therapy , Urea/therapeutic use , Dose-Response Relationship, Drug , Double-Blind Method , Humans , Ointments , PlacebosABSTRACT
Dermatological manifestations of chronic renal failure were studied in 35 cases. Xerosis was seen in 16 cases. Pruritus was observed in 12 cases and hyperpigmentation on exposed areas was seen in 8 patients. Acquired perforating disorder and half and half nail were seen in 6 cases each. Skin Biopsies performed in 6 cases of APD showed typical changes only in 3 cases.
ABSTRACT
Background : Vitiligo is a condition of major social and cosmetic concern in India. An epidemiological study of large number of patients from India was indicated.
Subject(s)
Skin/physiopathology , Sweat Glands/pathology , Vitiligo/physiopathology , Adolescent , Adult , Child , Child, Preschool , Electric Conductivity , Female , Humans , Male , Middle Aged , Vitiligo/pathologyABSTRACT
Fundamental factors influencing formation and subsequent behaviour of melanin are enumerated. Three most favoured hypotheses rea ng etiology of vitiligo are - 1 vitiligo is gardi an autoimmune disorder. 2. vitiligo is a neuro7 genic disorder. 3. vitiligo is caused as the result of self destruction of tnelanocytes. Steroids have proved very effective, in acute phase of autoimmune diseases and have anti-inflarnmatory action. On the assumption that these factors might be operative in, some vitiligo cases, ACTH therapy was instituted in, 27 cases. Effectiveness of treatment and untoward reactions have been discussed as also, some cases reports. It is concluded that the treatment is effective and duration of therapy considerably reduced.
ABSTRACT
A histological study of 74 vitiligo cases revealed inflammatory and degenerative changes in the epidermis, papillation, blood vessels, sweat glands and ducts, sebaceous glands and hair follicles, dermis (connective tissue), and dermal nerves and nerve endings.
Subject(s)
Skin/pathology , Vitiligo/pathology , Adolescent , Adult , Biopsy , Child , Child, Preschool , Female , Humans , Male , Middle Aged , Sebaceous Glands/pathology , Skin/innervation , Sweat Glands/pathologyABSTRACT
A 10-year-old girl developed epidermal nevus, shortness of limb, scoliosis, hemiatrophy with history of multiple pathological fractures. Bone biopsy revealed fibrous dysplasia. This is an extremely rare combination of epidermal nevus with fibrous dysplasia.