1.
Am J Med Sci
; 278(3): 207-15, 1979.
Article
in English
| MEDLINE
| ID: mdl-539598
ABSTRACT
Isoniazid, chloramphenicol and ethanol are well known hematopoietic toxins. These agents inhibit in vitro rabbit reticulocyte heme synthesis and, as a result, inhibit protein synthesis. When combinations of isoniazid (2 x 10(-3)M) and ethanol (0.1M), isoniazid and chloramphenicol (10(-3)M) or ethanol and chloramphenicol were present in the same incubation, their inhibitory effects on heme and protein synthesis were additive. These results suggest that the development of clinical hematological toxicity in man may result from additive interaction of chemically unrelated compounds which inhibit the heme synthetic pathway.
Subject(s)
Chloramphenicol/pharmacology , Ethanol/pharmacology , Globins/biosynthesis , Heme/analogs & derivatives , Heme/biosynthesis , Hemin/biosynthesis , Isoniazid/pharmacology , Reticulocytes/drug effects , Animals , Drug Interactions , Rabbits , Reticulocytes/metabolism
2.
Biochem Biophys Res Commun
; 80(4): 722-8, 1978 Feb 28.
Article
in English
| MEDLINE
| ID: mdl-637863