[Treatment of zoster oticus with acyclovir. Report from general practice and a small hospital department]. / Die Behandlung des Zoster oticus mit Aciclovir. Bericht aus Praxis und kleiner Krankenhausabteilung.

Findings in patients having zoster oticus infection are reported following treatment in an oto-rhino-laryngological practice connected to a small hospital department. Treatment involved intravenous administration of acyclovir and-in most cases-additional infusions of dextran, cortisone and naftidrofuryl, as adapted from a drug regimen proposed by Stennert. Although treatment was not effective in all cases, several very good results and some partial results were found that justified continued use of this combination therapy.

Plasma catecholamine concentration in hypertensive subjects with chronic renal failure before and during treatment with the beta-receptor blocking drug metipranolol.

In seven male hypertensive patients with chronic renal failure (serum creatinine level 6.9 +/- 4.1 mg%) plasma catecholamine levels were in the same range as in five normotensive healthy volunteers. Treatment with the beta-receptor blocker metipranolol (2 x 20 mg/day orally for 2 weeks) significantly elevated plasma catecholamine levels in the hypertensive patients with chronic renal failure, but not in the healthy volunteers. Blood pressure and heart rate were reduced in both groups.

[Preoperative chemotherapy of squamous cell carcinoma of the head and neck with V-T-M schedule (author's transl)]. / Präoperativ- chemotherapeutische Behandlung bei Plattenepithelkarzinomen im Kopf-Hals-Bereich mit dem V-B-M-Schema.

13 patients with far advanced squamous cell carcinoma of the head and neck were treated with a low dose combination chemotherapy of Vincristine, Bleomycin and Methrotrexate during 7--8 weeks prior to surgery or radio-therapy. V-B-M was given as an out- patient regimen. 9 patients were treated the first time ever, 4 patients suffered of tumor-recurrence. 5 patients i.e. 38% achieved complete remission of all measurable disease, a total of 9 patients i.e. 69% achieved a partial remission of more than 50%. Prior treatment or localisation of tumor did not influence the results. Competent application warranted, toxicity was mild. The significance of pre-operatively achieved complete remission is discussed. Short-term follow up does not yet permit any statement upon survival.

[Palliative chemotherapy of inoperable squamous cell cancer of the head and neck with V-B-M-schedule (author's transl)]. / Palliative Chemotherapie bei inoperablen Plattenepithel-Carcinomen im Kopf-Hals-Bereich mit dem V-B-M-Schema.

12 patients with far advanced head and neck squamous cell carcinoma, no longer apt to curative therapy, were submitted to palliative chemotherapy by V-B-M- schedule. Palliative therapy has great importance in this type of tumor, which due to its localisation causes terrible deformities and thus psychologically and sociologically forms a heavy burden. Nearly all patients became free of pain, exulcerations could be reduced, successfully general status could be improved. Due to an out patient regimen patients remained at home. Most of all this last circumstance helped to realize true palliative therapy; toxicity was mild.