ABSTRACT
INTRODUCTION: The study purpose was to evaluate tracheal intubating conditions and cardiovascular effects of rocuronium (roc) and vecuronium (vec) in the transport setting. METHODS: A prospective blinded study of adult patients requiring emergency rapid sequence oral tracheal intubation using direct laryngoscopy. Patients received equipotent doses of roc 1.0 mg/kg (n = 44) or vec 0.15 mg/kg (n = 56) on an alternate day basis. RESULTS: Intubation was successful in 95% of patients in the vec group and 100% in the roc group. The percentage of patients having good or excellent jaw relaxation and vocal cord exposure was similar between groups (vec/79%, roc/77%). Eleven patients (vec/7, roc/4) had difficult intubation as evidenced by Grade III or IV view and more than three attempts. Five patients in the vec group had inadequate neuromuscular blockade versus 1 patient in the roc group (P = 0.17). No cardiovascular differences occurred between groups after intubation. CONCLUSION: Tracheal intubating conditions and clinical evidence of complete neuromuscular blockade tended to be better after roc than after vec.
Subject(s)
Androstanols/administration & dosage , Emergency Medical Services , Intubation, Intratracheal , Neuromuscular Nondepolarizing Agents/administration & dosage , Vecuronium Bromide/administration & dosage , Adult , Androstanols/pharmacology , Female , Hemodynamics/drug effects , Humans , Laryngoscopy , Male , Middle Aged , Neuromuscular Nondepolarizing Agents/pharmacology , Ohio , Prospective Studies , Rocuronium , Transportation of Patients , Vecuronium Bromide/pharmacologyABSTRACT
BACKGROUND: The purpose of this study was to evaluate the efficacy of an experimental approach to forced air warming using hospital blankets or a Bair Hugger warming unit (Augustine Medical Inc., Eden Prairie, MN) to create a tent of warm air. METHODS: Adult patients undergoing major surgery were studied. Patients were randomized to receive forced air warming using either a commercial Bair Hugger blanket (control group, n = 44; set point, 43 degrees C) or standard hospital blankets (experimental group, n = 39; set point, 38 degrees C). Distal esophageal temperatures were monitored. Patients were contacted the following day regarding any problems with the assigned warming technique. RESULTS: Surface area covered was 36 +/- 12% (mean +/- SD) in the experimental group and 40 +/- 10% in the control group. Final temperatures at the end of surgery were similar between groups: experimental, 36.2 +/- 0.6 degrees C; control, 36.4 +/- 0.7 degrees C. A similar number of patients had esophageal temperature less than 36 degrees C at the end of surgery in both groups (experimental, 12 of 39 [31%]; control, 12 of 44 [27%]). The majority of patients were satisfied with their anesthetic and warming technique: experimental, 38 of 39 patients; control, 44 of 44 patients. There were no thermal injuries. CONCLUSIONS: Standard hospital blankets heated to 38 degrees C forced air were equally as effective as commercial blankets heated with forced air at 43 degrees C. However, based on concerns expressed by the manufacturer, this experimental technique should not be used until further safety evaluation has been undertaken.