Effects of Astaxanthin supplementation on selected metabolic parameters, anthropometric indices, Sirtuin1 and TNF-α levels in patients with coronary artery disease: A randomized, double-blind, placebo-controlled clinical trial.

Background: Atherosclerosis can develop as a result of an increase in oxidative stress and concurrently rising levels of inflammation. Astaxanthin (AX), a red fat-soluble pigment classified as a xanthophyll, may be able to prevent the vascular damage induced by free radicals and the activation of inflammatory signaling pathways. The objective of the current study is to assess the effects of AX supplementation on cardiometabolic risk factors in individuals with coronary artery disease (CAD). Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 50 CAD patients. Participants were randomly allocated into two groups to intake either AX supplements (12 mg/day) or placebo for 8 weeks. Lipid profile, glycemic parameters, anthropometric indices, body composition, Siruin1 and TNF-α levels were measured at baseline and after 8 weeks. Results: Body composition, glycemic indices, serum levels of TNF-α, Sirtuin1 did not differ substantially between the AX and placebo groups (p > 0.05). The data of AX group showed significant reduction in total cholesterol (-14.95 ± 33.57 mg/dl, p < 0.05) and LDL-C (-14.64 ± 28.27 mg/dl, p < 0.05). However, TG and HDL-C levels could not be affected through AX supplementation. Conclusion: Our results suggest that AX supplementation play a beneficial role in reducing some components of lipid profile levels. However, further clinical investigations in CAD patients are required to obtain more conclusive findings. Clinical trial registration: www.Irct.ir., identifier IRCT20201227049857N1.

Effects of Probiotics Supplementation on CRP, IL-6, and Length of ICU Stay in Traumatic Brain Injuries and Multiple Trauma Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Method: This meta-analysis aims to evaluate the effectiveness of probiotics in reducing inflammatory biomarkers and the length of intensive care unit (ICU) stays. PubMed-Medline, SCOPUS, Embase, and Google Scholar databases up to July 2021 were searched. The meta-analysis was carried out using random-effect analysis. To determine the sources of heterogeneity, subgroup analyses were performed. In case of the presence of publication bias, trim and fill analysis was carried out. The Cochrane Collaboration tool was used for checking the quality assessment. We hypothesized that probiotics would improve inflammatory markers (CRP and IL-6) and the length of ICU stay in traumatic brain injury and multiple trauma patients. Results: The present meta-analysis, which includes a total of seven studies, showed that there were no significant effects of probiotics supplementation on interleukin (IL)-6 (Hedges's g = -2.46 pg/ml; 95% CI: -12.16, 7.25; P=0.39), C-reactive protein (CRP) (Hedges's g = -1.10 mg/L; 95% CI: -2.27, 0.06; P=0.06), and the length of staying in ICU. The overall number of RCTs included in the analysis and the total sample size were insufficient to make firm conclusions. Conclusion: As a result, more carefully designed RCTs are needed to investigate the effect of probiotics on inflammatory biomarkers and the length of ICU stay in traumatic brain injuries and multiple trauma patients in greater detail.

Ammonium metavanadate (NH4VO3): a highly efficient and eco-friendly catalyst for one-pot synthesis of pyridines and 1,4-dihydropyridines.

In this study, we reported the ammonium metavanadate (NH4VO3) as an efficient, cost-effective, and mild catalyst for the synthesis of substituted pyridines via a one-pot pseudo four-component reaction. Furthermore, we investigated Hantzsch 1,4-dihydropyridines (1,4-DHPs) synthesis and oxidation of 1,4-DHPs to their corresponding pyridines. The present approach offers a rapid methodology for accessing various pyridines with broad functional group tolerance and good yields using NH4VO3 catalyst as a green catalyst.

Reorganization Energies for Interfacial Electron Transfer across Phenylene Ethynylene Rigid-Rod Bridges.

A family of three ruthenium bipyridyl rigid-rod compounds of the general form [Ru(bpy)2(LL)](PF6)2 were anchored to mesoporous thin films of tin-doped indium oxide (ITO) nanocrystals. Here, LL is a 4-substituted 2,2-bipyridine (bpy) ligand with varying numbers of conjugated phenylenethynylene bridge units between the bipyridine ring and anchoring group consisting of a bis-carboxylated isophthalic group. The visible absorption spectra and the formal potentials, Eo(RuIII/II), of the surface anchored rigid-rods were insensitive to the presence of the phenylene ethynylene bridge units in 0.1 M tetrabutyl ammonium perchlorate acetonitrile solutions (TBAClO4/CH3CN). The conductive nature of the ITO enabled potentiostatic control of the Fermi level and hence a means to tune the Gibbs free energy change, -ΔG°, for electron transfer from the ITO to the rigid-rods. Pseudo-rate constants for this electron transfer reaction increased as the number of bridge units decreased at a fixed -ΔG°. With the assumption that the reorganization energy, λ, and the electronic coupling matrix element, Hab, were independent of the applied potential, rate constants measured as a function of -ΔG° and analyzed through Marcus-Gerischer theory provided estimates of Hab and λ. In rough accordance with the dielectric continuum theory, λ was found to increase from 0.61 to 0.80 eV as the number of bridge units was increased. In contrast, Hab decreased markedly with distance from 0.54 to 0.11 cm-1, consistent with non-adiabatic electron transfer. Comparative analysis with previously published studies of bridges with an sp3-hybridized carbon indicated that the phenylene ethynylene bridge does not enhance electronic coupling between the oxide and the rigid-rod acceptor. The implications of these findings for practical applications in solar energy conversion are specifically discussed.

Self-Assembled Monolayers for Improved Charge Injection of Silver Back Electrodes in Inverted Organic Electronic Devices.

Self-assembled monolayers (SAMs) formed from thiol compounds bound to Ag and Au electrodes have been used as an important strategy in improving the stability and efficiency of optoelectronic devices. Thiol compounds provide only one binding site with the metal electrode which limits their influence. Dithiolane/dithiol compounds can provide multiple binding sites and could be useful in enhancing the performance of the device. In this study, inverted organic semiconducting hole-only devices were fabricated by using Ag back electrodes in conjunction with SAMs formed from disulfide lipoic acid-based compounds and were compared to a long aliphatic chain thiol. The binding and the electronic properties as well as electrical characteristics of the SAMs on silver were studied to look at the influence of their structure on charge injection in the organic semiconductor devices. It was found that the SAMs formed with (±)-α-lipoic acid, isolipoic acid, and (±)-4-phenylbutyl 5-(1,2-dithiolan-3-yl) pentanoate significantly improved the charge injection by either changing the work function of the Ag or altering the physical interaction between the polymer and the metal surface. This study may lead to an understanding of how the nature of the functional groups of the SAM and the number of bonds formed between each SAM molecule and the metal electrode influence the contact resistance and the performance of organic semiconductor devices.