ABSTRACT
The purpose of this study was to determine the relationship between sarcoma tumor grade and the quantitative tumor metabolism value for [F-18]fluorodeoxyglucose (FDG) determined by positron emission tomography (PET) imaging. Seventy patients with bone or soft-tissue sarcomas underwent PET scanning with quantitative determination of tumor FDG metabolic rate (MRFDG) before treatment. MRFDG (micromol/g/min) for each tumor was compared with National Cancer Institute tumor grade, S-phase percentage, and percentage of aneuploidy of the tumor population. The pretreatment quantitative determination of tumor MRFDG by PET correlates strongly with tumor grade but not with the other selected histopathological tumor correlates. In addition, overlap of MRFDG PET values with tumor grade suggests that PET, an objective tumor measurement, may provide an alternative means of assessing tumor biological potential or may have the potential to overcome some of the limitations of traditional pathological evaluation. FDG PET can uniquely provide a metabolic profile of a diverse group of sarcomas noninvasively and provide clinically relevant tumor biological information.
Subject(s)
Fluorodeoxyglucose F18 , Radiopharmaceuticals , Sarcoma/diagnostic imaging , Soft Tissue Neoplasms/diagnostic imaging , Adult , Aged , Aged, 80 and over , Disease Progression , Fluorodeoxyglucose F18/pharmacokinetics , Humans , Middle Aged , Radiopharmaceuticals/pharmacokinetics , Sarcoma/metabolism , Sarcoma/pathology , Soft Tissue Neoplasms/metabolism , Soft Tissue Neoplasms/pathology , Tomography, Emission-ComputedABSTRACT
A retrospective study in children with simple or unicameral bone cysts treated with curettage, cryosurgery, and bone grafting was conducted. The purpose of this study was to evaluate local tumor control and bony healing after this method of treatment. Five (12%) of 42 treated patients had a local recurrence with a mean clinical follow-up of 24.5 months. Surgical complications consisted of two superficial wound infections, one radial nerve palsy, and two fractures, which all resolved completely. A review of the literature was performed to compare our results with historic controls using steroid-injection therapy and curettage with bone grafting alone. We believe that the use of cryosurgery as adjuvant therapy in the surgical treatment of simple bone cysts is of value in controlling local recurrences and achieving bony consolidation.