The effect of interpersonal relationship and epidemic attention on negative emotion among medical students: the mediating role of social satisfaction.

BACKGROUND: Individuals are required to avoid close contact to reduce the probability of contracting the virus during the epidemics, which can lead to social isolation and exacerbate interpersonal relationship issues. Social satisfaction plays a crucial role in management in the period of pandemics and is strongly correlated with negative emotion. Medical students, as a special group of students, have a heavier burden of academic workload and greater pressure. They are also more likely to have access to epidemic information, which increases their susceptibility to negative emotions such as depression and anxiety. Therefore, it is necessary to investigate the impact and mechanisms among interpersonal, epidemic attention, social satisfaction, and negative emotions during the epidemics outbreak among medical students for improving the level of mental health in the post-epidemic era. METHODS: A total of 1,451 university students were included in this study. Self-administered questionnaires, including the Comprehensive Interpersonal Relationship Diagnostic Scale, the Self-Rating Anxiety Scale, and the Self-Rating Depression Scale, were utilized to construct structural equations to examine the mediating effects of social satisfaction. The study employed a multi-stage whole-group sampling approach for university students. RESULTS: Interpersonal relationships and epidemic attention positively predicted negative emotion levels. Interpersonal relationships negatively predicted social satisfaction, while epidemic attention positively predicted social satisfaction. Moreover, social satisfaction negatively predicted negative emotion levels. Notably, both interpersonal relationships and epidemic attention indirectly affected negative emotions through the mediating effect of social satisfaction. CONCLUSIONS: Social satisfaction plays a mediating role in the effect of interpersonal relationships and epidemic attention on negative emotion. In the post-epidemic era, it is crucial to enhance support from family, school and society to improve social satisfaction of medical students. Immediate identification of negative emotions is essential, and targeted strategies should be developed to address mental health issues among medical students.

The rewarding compensatory mechanism of music enhances the sense of fairness.

Whether music can influence moral judgment is controversial in the aesthetics and philosophy of music. Aesthetic Autonomy pointed out that music had a morally educational function because of its lyrics or a particular context. The key to resolving the divergence is to select absolute music without lyrics or specific context as the eliciting material. In this study, 84 participants were recruited and randomly divided into three groups to complete the Ultimatum Game (UG) after listening to different stimuli: absolute music, white noise, and no sound. Behavioral results indicated that the participants' acceptance of unfair offers was significantly lower in the music group. Also, participants in the music group have a shorter reaction time for rejecting an unfair offer than other unfair conditions. However, ERP comparison showed no significant difference in medial frontal negativity (MFN) amplitude, which reflects fairness levels, between the music group and the no sound group for either accepting or rejecting the moderately unfair offer. Brain network analyses revealed that participants in the music group showed stronger activation of rewarding circuits, including the ventral striatum, during the decision-making process of rejecting unfair offers, before the decision especially, compared to the no sound group. These results suggest that absolute music can influence fair decision-making. The reward activated by music compensates participants vicariously for the reward they receive for choosing self-interest in an unfair offer, participants no longer have to choose between self-interest and fairness norms, so the participants reject the unfair offer due to the negative emotions induced by the unfair offer.

The Benefits of Music Listening for Induced State Anxiety: Behavioral and Physiological Evidence.

BACKGROUND: Some clinical studies have indicated that neutral and happy music may relieve state anxiety. However, the brain mechanisms by which these effective interventions in music impact state anxiety remain unknown. METHODS: In this study, we selected music with clinical effects for therapy, and 62 subjects were included using the evoked anxiety paradigm. After evoking anxiety with a visual stimulus, all subjects were randomly divided into three groups (listening to happy music, neutral music and a blank stimulus), and EEG signals were acquired. RESULTS: We found that different emotional types of music might have different mechanisms in state anxiety interventions. Neutral music had the effect of alleviating state anxiety. The brain mechanisms supported that neutral music ameliorating state anxiety was associated with decreased power spectral density of the occipital lobe and increased brain functional connectivity between the occipital lobe and frontal lobe. Happy music also had the effect of alleviating state anxiety, and the brain mechanism was associated with enhanced brain functional connectivity between the occipital lobe and right temporal lobe. CONCLUSIONS: This study may be important for a deep understanding of the mechanisms associated with state anxiety music interventions and may further contribute to future clinical treatment using nonpharmaceutical interventions.

Functional abnormalities of striatum are related to the season-specific effect on schizophrenia.

Schizophrenia is a syndrome that is typically accompanied by delusions, hallucinations and cognitive impairments. Specifically, abundant evidences support the notion that more people diagnosed with schizophrenia are born during fall-winter than spring-summer. Although pathophysiological of schizophrenia might be associated with abnormal brain functional network, little is currently known the relationship between season and deficient brain functional network of schizophrenia. To investigate this issue, in this study 51 schizophrenic subjects and 72 healthy controls underwent MRI scanning to detect the brain functional mapping, each at spring-summer and fall-winter season throughout the year. The data-driven method was used to measure the blood oxygen metabolism variability (BOMV). Decreased BOMV in spring-summer while increased in fall-winter were observed within dopaminergic network of schizophrenic subjects, including striatum, thalamus, and hippocampus. The post hoc analysis exploring the coupling among changed BOMV regions, confirmed that a positive relationship, between pallidum and hippocampus existed in fall-winter healthy controls, but not in fall-winter schizophrenic subjects. These findings identified that seasonal effect on striatum might be associated with modulation of striatum-hippocampus. Our results provide a new insight into the role of season in understanding the pathophysiological of schizophrenia.

Sad Music Modulates Pain Perception: An EEG Study.

BACKGROUND: Music has shown positive effects on pain management in previous studies. However, the relationship between musical emotional types and therapeutic effects remains unclear. To investigate this issue, this study tested three typical emotional types of music and discussed their neural mechanisms in relation to pain modulation. SUBJECTS AND METHODS: In this experiment, 40 participants were exposed to cold pain under four conditions: listening to happy music, listening to neutral music, listening to sad music and no sound. EEG and pain thresholds were recorded. The participants were divided into the remission group and the nonremission group for analysis. Differences among conditions were quantified by the duration of exposure to the pain-inducing stimulus in the remission group. EEG data were obtained using a fast Fourier transform (FFT) and then correlated with the behavioral data. RESULTS: We found that sad music had a significantly better effect on alleviating pain, as a result of brain oscillations in a higher beta band and the gamma band at the O2 and P4 electrodes. The comparison between the remission group and the nonremission group suggested that personality may affect music-induced analgesia, and dominance, liveliness and introvert and extrovert personality traits were associated with pain modulation by sad music. Additionally, in the network analysis, we compared brain networks under the three conditions and discussed the possible mechanisms underlying the better analgesic effect of sad music. CONCLUSION: Sad music may have a better effect on alleviating pain, and its neural mechanisms are also discussed. This work may help understand the effects of music on pain modulation, which also has potential value for clinical use.