Nutraceutical value and safety of tomato fruits produced by mycorrhizal plants.

Tomato fruit has assumed the status of 'functional food' due to the association between its consumption and a reduced likelihood of certain types of cancers and CVD. The nutraceutical value of tomatoes can be affected by the cultivation conditions, e.g. the phytochemical content of the fruits may increase with the establishment of beneficial mycorrhizal symbioses in the plants. A multidisciplinary study was carried out to gain knowledge on the antioxidant, oestrogenic/anti-oestrogenic and genotoxic activity of tomato fruits produced by mycorrhizal plants. The present results showed that the symbiosis positively affected the growth and mineral nutrient content of tomato plants and enhanced the nutritional and nutraceutical value of tomato fruits through modifications of plant secondary metabolism, which led to increased levels of lycopene in fruits obtained from mycorrhizal plants, compared with controls. Moreover, such changes did not result in the production of mutagenic compounds, since tomato extracts induced no in vitro genotoxic effects. Fruit extracts, both hydrophilic and the lipophilic fractions, originating from mycorrhizal plants strongly inhibited 17-ß-oestradiol-human oestrogen receptor binding, showing significantly higher anti-oestrogenic power compared with controls. The present study shows that beneficial plant symbionts, such as mycorrhizal fungi, can lead to the production of safe and high-quality food, which is an important societal issue strongly demanded by both consumers and producers.

Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E(2)-dependent plaque instability.

BACKGROUND: Studies have implicated a role for prostaglandin (PG) E(2)-dependent matrix metalloproteinase (MMP) biosynthesis in the rupture of atherosclerotic plaque. Cyclooxygenase-2 (COX-2) and PGE synthase (PGES) are coregulated in nucleated cells by inflammatory stimuli. The aim of this study was to characterize the expression of COX-2 and PGES in carotid plaques and to correlate it with the extent of inflammatory infiltration and MMP activity and with clinical features of patients' presentation. METHODS AND RESULTS: Plaques were obtained from 50 patients undergoing carotid endarterectomy and divided into 2 groups (symptomatic and asymptomatic) according to clinical evidence of recent transient ischemic attack or stroke. Plaques were analyzed for COX-2, PGES, MMP-2, and MMP-9 by immunocytochemistry and Western blot, whereas zymography was used to detect MMP activity. Immunocytochemistry was used to identify CD68+ macrophages, CD3+ T lymphocytes, and HLA-DR+ cells. The percentage of macrophage-rich areas was larger (P<0.0001) in symptomatic plaques. COX-2, PGES, and MMPs were detected in all specimens; enzyme concentration, however, was significantly higher in symptomatic plaques. COX-2, PGES, and MMPs were especially noted in shoulders of symptomatic plaques, colocalizing with HLA-DR+ macrophages. All symptomatic plaques contained activated forms of MMPs. Finally, inhibition of COX-2 by NS-398 was accompanied by decreased production of MMPs that was reversed by PGE(2). CONCLUSIONS: This study demonstrates the colocalization of COX-2 and PGES in symptomatic lesions and provides evidence that synthesis of COX-2 and PGES by activated macrophages is associated with acute ischemic syndromes, possibly through metalloproteinase-induced plaque rupture.

Elevated circulating levels of monocyte chemoattractant protein-1 in patients with restenosis after coronary angioplasty.

Inflammation plays a pathogenic role in the development of restenosis after percutaneous transluminal coronary angioplasty (PTCA). Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant of monocytes; however, its role in the pathophysiology of restenosis is still unclear. We set out to investigate the role of MCP-1 in restenosis after PTCA. In addition, we tested the hypothesis that MCP-1 exerts its effect, at least in part, by inducing O(2)(-) generation in circulating monocytes. Plasma levels of MCP-1 were measured before and 1, 5, 15, and 180 days after PTCA in 50 patients (30 males and 20 females, aged 62+/-5 years) who underwent PTCA and who had repeated angiograms at 6-month follow-up. Restenosis occurred in 14 (28%) patients. The MCP-1 level was no different at baseline between patients with or without restenosis. However, after the procedure, restenotic patients, compared with nonrestenotic patients, had statistically significant (P<0.0001) elevated levels of MCP-1. In contrast, plasma levels of other chemokines, such as RANTES and interleukin-8, did not differ between the 2 groups after PTCA. Higher MCP-1 throughout the study was correlated with restenosis. Moreover, increased MCP-1 was significantly correlated with increased monocyte activity, as reflected by enhanced O(2)(-) generation. Finally, multivariate regression analysis showed that the MCP-1 plasma level measured 15 days after PTCA was the only statistically significant independent predictor of restenosis (beta=0.688, P<0.0001). This study suggests that MCP-1 production and macrophage accumulation in the balloon-injured vessel may play a pivotal role in restenosis after PTCA. MCP-1 may induce luminal renarrowing, at least in part, by inducing O(2)(-) release in monocytes. Further understanding of the mechanism(s) by which MCP-1 is produced and acts after arterial injury may provide insight into therapies to limit the progression of atherosclerosis and restenosis after balloon angioplasty.

Relationship between reduced BCL-2 expression in circulating mononuclear cells and early nephropathy in type 1 diabetes.

Microalbuminuria is the earliest clinical evidence of diabetic nephropathy, but the mechanisms linking hyperglycemia and kidney complications are not clear. The aim of this study was to evaluate whether enhanced oxidative stress in patients with microalbuminuria can contribute to diabetic nephropathy development through downregulation of the antiapoptotic gene Bcl-2 that promotes in turn a pro-inflammatory status. We studied 30 patients with type 1 diabetes (15 with and 15 without microalbuminuria) compared to 15 matched healthy controls. Plasma oxidant status, and expression of Bcl-2, activated NF-kB, inducible Nitric Oxide synthase (iNOS), and monocyte chemoattractant protein (MCP)-1 in circulating monocytes were evaluated at baseline and after 8-week oral vitamin E treatment (600 mg b.i.d.). Bcl-2 expression was significantly reduced in microalbuminuric diabetic patients as a consequence of increased oxidant burden secondary to persistent hyperglycemia. Bcl-2 down-regulation was associated with enhanced expression of NF-kB, iNOS and MCP-1, and showed a strong correlation with the albumin excretion rate. Low Bcl-2 expression and high inflammatory status were normalized by vitamin E both in vivo and in vitro. Our study showed that Bcl-2 down-regulation in diabetic patients with poor glycemic control results in the activation of the NF-kB pathway leading to the development of nephropathy. Vitamin E might provide a novel form of therapy for prevention of nephropathy in diabetic patients in which an acceptable glycemic control is difficult to achieve despite insulin therapy.

Relations of employment status to emotional distress among chronic pain patients: a path analysis.

OBJECTIVE: This cross-sectional study evaluated the extent to which relations between employment status and emotional distress are mediated by pain-related and psychosocial measures among employed and unemployed persons with chronic pain. DESIGN: A total of 40 unemployed and 43 employed persons reporting chronic pain were recruited from pain services at a tertiary-care hospital and community-based organizations. Volunteers completed self-report measures of pain severity, subjective financial stress, time structure, emotional distress, and background data. RESULTS: A path analysis indicated that pain severity had direct associations with both emotional distress and employment status. In addition, employment status was only indirectly related to emotional distress; this relation was mediated by levels of reported financial strain and structured purposeful time use. CONCLUSIONS: Findings suggest that pain severity and the quality of specific experiences related to being employed or unemployed as opposed to employment status per se correspond directly to levels of emotional distress reported by some persons with chronic pain.

Magnetic resonance angiography compared with basic magnetic resonance in intracranial vascular diseases.

The diagnostic value of magnetic resonance angiography (MR-Angio) in the study of intracranial vascular diseases was compared with that of basic magnetic resonance (MR) in 35 patients presenting with a total of 45 pathologies (13 vascular malformations, 17 aneurysms, 3 vascular stenoses, all also examined by standard angiography, and 12 cases of dolichobasilar artery). A joint reading of the results was carried out by two radiologists who evaluated the basic MR and MR-Angio separately and thereafter filled in a fixed-choice answer form. In the author's opinion, MR-Angio may be considered a complementary technique to basic MR, offering a greater capacity for identification and characterization of these intracranial lesions. In vascular malformations and aneurysms, MR-Angio may be performed as a preliminary to digital subtraction angiography.

[Auditory brain stem evoked potentials in the evaluation of chronic fatigue syndrome]. / I potenziali evocati uditivi troncoencefalici nella valutazione della sindrome da fatica cronica.

The Chronic Fatigue Syndrome (CFS) was formally defined to describe disabling fatigue of multifactorial ethology with depression and immunologic dysfunctions linked to some currently recognized infectious agents. In most cases neurophysiological tests reveal abnormalities. In this paper the Authors use low (11 pps) and high (51-71 pps) frequency ABR to evaluate the electrophysiological function of auditory brainstem responses. Eighteen patients with suspected CFS, between the ages of 17 and 63, were examined. Eleven subjects had clinically diagnosed "true" CFS (CDC criteria modified by Fukuda). The 11 pps frequency test did not reveal a high number of abnormalities in the patients in question. However, the high frequency stimulation test (with 51 and 71 pps) which was statistically significant (P = 0.009) revealed numerous aberrations in 7 patients; absence of the first wave in 1 case, in 5 numerous wave gap delays and in 1 patient absence of the first wave and numerous wave gap delays. The high frequency test did not show many abnormalities for the 4 remaining patients. For the 7 "non CFS" subjects, the clinical-audiological comparison showed no statistical significance (P = 0.920). The Authors hypothesize that the absence of the first wave in the CFS Subject may well indicate a cyto-neural junction disease in the organ of Corti. The combined analysis of clinical and audiological data showed that the described tests are more reliable when employed in dealing with patients with clinically assessed "true" CFS.

Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus: effect of improved metabolic control.

AIMS/HYPOTHESIS: Inflammation plays a pathogenic role in the development of accelerated atherosclerosis in diabetes. Soluble CD40 ligand (sCD40L) is enhanced in diabetes; however, the molecular mechanisms linking sCD40L to accelerated atherosclerosis in diabetes are still unclear. We tested the hypothesis that sCD40L may be involved in the vascular complications in diabetes and exerts its effect by triggering inflammatory reactions on mononuclear and endothelial cells (ECs). METHODS: We studied 70 patients, 40 with type 2 and 30 with type 1 diabetes, with a history or physical examination negative for cardiovascular disease, and 40 non-diabetic and 30 healthy subjects, matched with the type 2 and type 1 diabetic patients, respectively. Plasma and serum sCD40L, and plasma soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, E-selectin and monocyte chemo-attractant protein-1 (MCP-1) were measured. Adhesion molecules and MCP-1 release, the ability to repair an injury in ECs, and O2- generation in monocytes were analysed in vitro after stimulation with serum from patients or controls. RESULTS: Type 2 and type 1 diabetic patients had significantly higher sCD40L levels than controls. Furthermore, high sCD40L was associated with in vitro adhesion molecules and MCP-1 release, impaired migration in ECs and enhanced O2- generation in monocytes. Improved metabolic control was associated with a reduction of plasma sCD40L by 37.5% in 12 type 1 diabetic patients. Furthermore, elevated sCD40L in diabetic patients was significantly correlated with HbA1c levels. CONCLUSIONS/INTERPRETATION: Upregulation of sCD40L as a consequence of persistent hyperglycaemia in diabetic patients results in EC activation and monocyte recruitment to the arterial wall, possibly contributing to accelerated atherosclerosis development in diabetes.

The impact of psychosocial features of employment status on emotional distress in chronic pain and healthy comparison samples.

This study examined the extent to which measures of psychosocial features of employment status predict emotional distress in chronic pain (n = 83) and healthy comparison (n = 88) samples. Participants completed measures of emotional distress, pain severity, psychosocial features of employment status, and demographic data. After controlling for length of current unemployment, number of pain sites, and level of current pain severity, psychosocial measures (structured and purposeful time use, perceived financial security, skill use, social support form formal sources) were significant predictors of emotional distress in the chronic pain sample. Similar results were obtained for the healthy comparison sample. Structured and purposeful time use emerged as the most significant individual predictor of emotional distress for both samples. Findings are discussed in terms of their potential implications for treating chronic pain patients and the need to develop multidimensional measures that assess features of employment status within chronic pain samples.

The differential effects of employment status on chronic pain and healthy comparison groups.

We evaluated the differential effects of employment status on chronic pain and healthy comparison groups. Forty unemployed and 43 employed individuals with chronic pain, as well as 43 unemployed and 45 employed healthy comparison participants completed a series of measures assessing background information physical and psychological adjustment, and psychosocial features of employment status. In general, participants experiencing both chronic pain and unemployment reported poorer adjustment than the other groups and more financial strain, less structured and purposeful activity, fewer opportunities for skill use and task variety, and decreased social support than the employed chronic pain and healthy comparison groups. Groups did not differ, however, in work ethic values. Scores on measures of pain severity and features of employment status accurately predicted the group membership of more than 70% of respondents from four groups. The study suggests that there is utility in understanding experiences of chronic pain patients on the basis of features of their current employment status and points to a need for multidimensional measures that evaluate psychosocial facets of employment and unemployment specifically for chronic pain samples.

[Carotid bifurcation: angiography with magnetic resonance versus carotid angiography]. / Biforcazione carotidea: angiografia con risonanza magnetica versus carotidografia.

The reliability of Magnetic Resonance Angiography (MRA) was investigated in the study of stenosis and obstruction of carotid bifurcation; digital carotidography was the gold standard. Twenty-five consecutive patients with clinical suspicion of cerebrovascular insufficiency entered the study. MRA was performed with a 1.5 T superconductive magnet (Magnetom Siemens) and a linear head coil. The TOF 3D (FA 20 degrees, TR 30 ms, TE 7 ms) technique was applied. Images were acquired on the sagittal plane and rotated in postprocessing according to MIP on the z axis from 60 to 120 degrees (step 5). MRA exhibit 80.5% sensitivity, 96% specificity, 89.4% accuracy, 94.7% positive predictive value and 86.3% negative predictive value. When calculating the interrupted flow relative to hemodynamically significant stenoses (range 31%-occlusions), MRA sensitivity was 80.5%, specificity 100%, negative predictive value 86.3%, positive predictive value 94.7% and overall diagnostic accuracy 91.2%. MRA is to be considered a diagnostically reliable procedure in the study of carotid bifurcation and its diagnostic accuracy may even be increased in the future by the possible assessment of over- and underestimated cases.

[Whole body MR angiography. Physiologic presaturation++ of the inferior vena cava]. / Angio-RM del corpo. Presaturazione fisiologica della vena cava inferiore.

Whole-body MRA, performed with the time-of-flight (TOF) technique requires presaturation pulses adequately positioned and to eliminate the arterial and/or venous signal (FRODO technique: "Flow Respiratory artifact Obliteration with Directed Orthogonal pulses"). Additional presaturation pulses involve an increase in the radiofrequency dose absorbed by the patient, frequently over 0.4 watt x kg, which is the threshold absorption per kg. In the present paper, the possible saturation of caval system exploiting the modulation of apnea in whole-body MRA was investigated. Ten volunteers and 10 patients with different diseases were studied. All subjects underwent abdominal MRA with the TOF 2D (FA 18 degrees, TR 22 ms, TE 10 ms) technique. Images were acquired with three modulations of apnea: maximum inspiration, expiration, Müller maneuver. With respect to the anteroposterior diameter of inferior vena cava in inspiration, the inferior cava was reduced by 21.7% in expiration and by 35.7% in Müller maneuver. The lower caliber of vena cava allowed selective angiogram of the aorta. Expiration maneuvers are suggested as an alternative to caval flow saturation by the FRODO technique. As for expiration maneuvers, the volunteers and patients studied preferred to modulate the apnea in forcible expiration. Müller maneuver, through more effective (in 4 cases total caval collapse was obtained) is nonetheless more difficult.

Randomised trial of oral morphine for chronic non-cancer pain.

BACKGROUND: The use of opioid analgesics for chronic non-cancer pain is controversial. Some surveys report good pain relief and improvement in performance while others suggest a poor outcome with a propensity to psychological dependence or addiction. METHODS: We undertook a randomised double-blind crossover study to test the hypothesis that oral morphine relieves pain and improves the quality of life in patients with chronic regional pain of soft tissue or musculoskeletal origin who have not responded to codeine, anti-inflammatory agents, and antidepressants. Morphine was administered as a sustained-release preparation in doses up to 60 mg twice daily and compared with benztropine (active placebo) in doses up to 1 mg twice daily over three-week titration, six-week evaluation, and two-week washout phases. Pain intensity, pain relief, and drug liking were rated weekly and psychological features, functional status, and cognition were assessed at baseline and at the end of each evaluation phase. FINDINGS: After dose titration in the 46 patients who completed the study, the mean daily doses of drugs were morphine 83.5 mg and benztropine 1.7 mg. On visual analogue scales, the morphine group showed a reduction in pain intensity relative to placebo in period I (p = 0.01) and this group also fared better in a crossover analysis of the sum of pain intensity differences from baseline (p = 0.02). No other significant differences were detected. INTERPRETATION: In patients with treatment-resistant chronic regional pain of soft-tissue or musculoskeletal origin, nine weeks of oral morphine in doses up to 120 mg daily may confer analgesic benefit with a low risk of addiction but is unlikely to yield psychological or functional improvement.

Magnetic resonance angiography of the left renal vein.

The authors evaluated magnetic resonance angiography (MRA) as a possible diagnostic method to image the left renal vein. Twenty-five patients with abdominal aortic aneurysm underwent both plain and contrast-enhanced CT, as well as two-dimensional (2D) sequential time of flight (TOF) MRA. MRA images were evaluated on the basis of the results of CT, taken as the "gold standard" for vessel demonstration. MRA was performed with a 1.5 T superconductive magnet (Magnetom), fast imaging with steady-state free precession (FISP) 2D sequence (TR 40 ms, TE 10 ms, FA 18 degrees). Images were acquired in breath-hold on the coronal and sagittal plane and reconstructed according to maximum intensity projection (MIP) and targeted-MIP techniques. MRA images acquired on the sagittal plane correctly showed the retroaortic course on the left renal v. in six cases. On the coronal plane, targeted-MIP reconstructions for the course of the left renal v. correctly detected its outlet at the level of the inferior vena cava in five cases and of the left iliac v. in one case. MRA appears to be a promising noninvasive vascular imaging technique capable of correctly detecting the course and the outlet of the left renal v. We particularly noticed that the left renal v. can be imaged in a few seconds by using only one scout view with 2D sequential TOF technique on the sagittal plane at the level of the abdominal aorta.

Somatothymia in chronic pain patients.

Somatothymia is the use of somatic language to communicate affective distress. A total of 152 chronic pain patients completed a systems review checklist and the Minnesota Multiphasic Personality Inventory. Associated features of somatic symptoms and the meaningfulness of somatic symptoms as a communication, common physical areas of somatic focus, patterns of affective distress in high and low somatothymics, and the utility of select variables classifying high and low somatothymics were evaluated. The results indicate that a systems review checklist can be used as a quick, useful, and initial screen for somatothymia and that somatic symptoms can in fact communicate affective distress.

[Aneurysm of the abdominal aorta. Angiography with magnetic resonance versus color Doppler ultrasonography]. / Aneurismi dell'aorta addominale. Angiografia con risonanza magnetica versus eco color Doppler.

This prospective study was aimed at comparing the diagnostic accuracy of Magnetic Resonance Angiography (MRA) with that of color-Doppler ultrasonography (color-Doppler US) in the detection and assessment of abdominal aortic aneurysms. Twenty patients with abdominal aortic aneurysms underwent MRA, color-Doppler US, digital subtraction angiography (DSA) and Computed Tomography (CT) on three consecutive days. Fourteen patients underwent surgical repair of the aneurysm. MRA and color-Doppler findings were compared with DSA, surgical and pathologic findings, which were considered as the gold standard. In the 6 patients who refused surgery, CT and DSA were considered the gold standard. MRA always correctly assessed the size and site of the aneurysm, the involvement of the renal and common iliac arteries, the retroarotic course of the left renal vein, the thrombotic component and calcifications. Color-Doppler US always correctly assessed the size and site of the aneurysm, the thrombotic component and calcifications and the involvement of the iliac arteries. In one case color-Doppler US failed to demonstrate the involvement of the renal arteries and the retroaortic course of the left renal vein. Our preliminary results suggest MRA as the best non-invasive technique to study abdominal aortic aneurysms.

[Neoplasms of the glomus caroticum: magnetic resonance angiography versus magnetic resonance]. / Neoplasie del glomo carotideo: angiografia con risonanza magnetica versus risonanza magnetica.

This work was aimed at investigating the diagnostic role of Magnetic Resonance angiography (MRA) versus spin-echo images in the study of carotid paragangliomas. Ten patients affected with carotid paragangliomas were studied; surgery was the gold standard. MR examinations were performed with a superconductive 1.5 T magnet and a linear head coil. T1-weighted (TR 500 ms, TE 15 ms, 256 x 256 matrix) and T2-weighted (TR 2000 ms, TE 15/90 ms, 256 x 256 matrix) spin-echo sequences were acquired. TOF 3D (flash: FA 25 degrees, TR 30 ms, TE 7 ms) MRA images were acquired; coronal and sagittal images were rotated according to the MIP. Spin-echo images demonstrated the typical "salt and pepper" pattern in all cases. In 6 cases (lesion diameter > 3 cm) the vascular structures of the paragangliomas and carotid dislocation were clearly demonstrated by MRA. MRA also depicted carotid dislocation in all cases. In conclusion, in the evaluation of carotid paragangliomas > 3 cm diameter, MRA yields complementary information on vascular structures and dislocation of carotid vessels to spin-echo MR sequences.

[Staging of pulmonary apex tumors. Computerized tomography versus magnetic resonance]. / Stadiazione dei tumori dell'apice polmonare. Tomografia computerizzata versus risonaza magnetica.

Apical lung cancers account for about 5% of pulmonary lesions and can be divided into two groups: Pancoast and non-Pancoast lesions. Recently, the use of MRI has been suggested in combination with CT to stage this kind of lung cancer. In this paper the authors' experience is reported relative to the current role of MRI and CT in the staging of apical lung cancers. Twelve male patients (mean age: 60.5 years) with apical lung cancers underwent conventional X-ray, CT and MR examinations of the chest. CT and MR images were studied by two independent radiologists with specific experience; surgery was the gold standard in three patients and MR and clinical symptoms in the patients not referred for surgery. In 15/108 cases (13.8%) CT and MR findings were in disagreement but in 93/108 cases (86.2%) they were in agreement. The highest disagreement rate was observed in the study of apical chest wall infiltration (33.3%), while in the study of anonymous vein involvement CT and MRI were always in agreement. The correct assessment of the regional extent of apical lung cancers is mandatory for treatment planning. In this kind of tumors MRI can be considered the method of choice thanks to its high contrast resolution and multiplanar imaging capabilities.

[2D TOF angio-MR of the thoraco-abdominal aorta. Technique and clinical applications]. / Angio-RM 2D TOF dell'aorta toraco-addominale. Tecnica e applicazinoni cliniche.

The diagnostic role of Magnetic Resonance Angiography (MRA) was investigated in the study of the thoracic and abdominal aorta. Thirty-two patients with different conditions were examined: the thoracic aorta was affected in 7 cases (3 aneurysms, 2 dissections, 2 tumors) and the abdominal aorta in 25 cases (21 aneurysms, 3 stenoses and 1 dissection). Moreover, 2 kinkings and 1 dextroposition of the thoracic aorta were observed as occasional findings, together with 15 abdominal aorta kinking cases. A 1.5-T superconductive magnet (Magnetom, Siemens) with circular polarization body coil and the 2D TOF (FL 18 degrees, TR 30 ms, TE 10 ms, ST 5 mm, 1-mm overlap) technique were used. The images acquired on the coronal and sagittal or parasagittal planes were rotated from -45 degrees to 45 degrees and from 60 degrees to 120 degrees during post-processing, according to MIP. Digital angiography was the gold standard in all cases, angiography and CT were the gold standards for aneurysms, and surgery for the lesions reaching the thoracic aorta. The 2D TOF technique allowed excellent visualization of both the thoracic and the abdominal aorta. In thoracic aorta conditions, MRA always identified aneurysms and assessed their relationship to epiaortic branchings. Moreover, MRA identified 2 cases of thoracic aorta dissection. In one case (1/2) MRA failed to depict aortic wall infiltration by tumor. In 21 abdominal aorta aneurysms, MRA always correctly demonstrated both the extent of the aneurysm and its relationships to renal and iliac arteries. Moreover, the thrombotic aneurysmal component was demonstrated, together with left renal vein course, which was retroaortic in 4 cases. Abnormal course, stenoses (2 cases) and dissection of the abdominal aorta were always identified by MRA.