Dorsal root ganglion-pulsed neuromodulation radiofrequency treatment has significant clinical efficacy in chronic spinal-origin pain, bringing noticeable improvement in symptoms and sleep quality for patients.

BACKGROUND: Chronic spinal-origin pain poses a substantial clinical challenge, prompting the investigation of novel treatment modalities. This study aims to evaluate the potential application of spinal nerve dorsal root ganglion (DRG) radiofrequency treatment in addressing chronic spinal-origin pain. METHODS: The study encompassed patients undergoing treatment for chronic spinal-origin pain, with a particular focus on those experiencing pain localized in specific regions. Inclusion criteria comprised patients with conditions such as a herniated intervertebral disc or foraminal stenosis leading to compression of descending or exiting nerve roots, accompanied by reported radicular pain in the lower limb. RESULTS: There was no significant difference in comparability between the two groups (p > 0.05). The clinical effective rate in the study group was significantly higher than that in the control group (p < 0.05). The VAS scores of the study group at 2 weeks and 1 month after treatment were significantly lower than those of the control group (p < 0.05). The PSQI index of the study group after treatment was significantly lower than that of the control group (p < 0.05). There was no significant difference in the incidence of complications between the two groups (p > 0.05). CONCLUSION: Spinal nerve DRG radiofrequency treatment has significant clinical efficacy in chronic spinal-origin pain, bringing noticeable improvement in symptoms and sleep quality for patients. The occurrence of complications is relatively low, and it can be reduced through strict operational standards and preoperative and postoperative management. However, caution should be exercised in its widespread application, but it is worthy of broad clinical use.

[1H-MRS study on the metabolites of first dorsal interossei].

OBJECTIVE: To estimate the application of prognosis evaluation of ulnar nerve injury by 1H-magnetic resonance spectroscopy (1H-MRS). METHODS: The metabolites of first dorsal interossei (FDI) of two hands from 12 healthy volunteers and 1 volunteer with complete ulnar nerve injury were detected by 1H-MRS and the data were statistically analyzed. RESULTS: For the FDI of healthy adults, the female peaks area of extra-myocellular lipids (EMCL) was higher than the male (P < 0.05); There was no significant difference in Cho, Cr and intra-myocellular lipids (IMCL) between male and female (P > 0.05); There was no significant difference in all the peaks area between the left and right hand (P > 0.05). The EMCL peak of the injury side was higher than that of the healthy side, and the area of FDI was reduced in the volunteer with ulnar nerve injury. CONCLUSION: Noninvasive and quantitative detection of 1H-MRS may be valuable for prognosis evaluation of peripheral nerve injury.

Analysis of Clinical Effect after Treatment of Patients with Femoral Neck Fracture Using Total or Hemihip Arthroplasty.

OBJECTIVE: To investigate the difference in clinical outcomes between total hip arthroplasty (THA) and hemiarthroplasty (HA) in patients with femoral neck fracture. METHOD: To retrospectively analyze 96 patients (96 hips) with femoral neck fracture treated in our hospital and distinguish them into THA group (50 patients with 50 hips) and HA group (46 patients with 46 hips) according to the difference of their chosen surgical procedure, and to compare the difference in perioperative indexes, postoperative hip function, occurrence of near and long-term complications, long-term imaging performance, and revision rate between the two groups. RESULT: The operating time, intraoperative blood loss, and total drainage were greater in the THA group than in the HA group (P < 0.05). At 6 months after surgery, the Harris score of the hip joint was higher in the HA group than in the THA group. At 3 years after surgery, the Harris score was higher in the THA group than in the HA group (P < 0.05). At 3 years after surgery, the excellent hip function rates were 86.00% and 67.39% in the THA and HA groups, respectively, with statistically significant difference between the groups. The incidence of long-term complications was significantly lower in the THA group than in the HA group (P < 0.05). The anteversion and abduction angles of patients in the HA group were smaller than those in the THA group at 6 months after surgery (P < 0.05). The WOMAC scores of the THA group were better than those of the HA group at 3 years after surgery (P < 0.05). CONCLUSION: Compared with hemiarthroplasty, total hip arthroplasty has a longer operative time and more postoperative bleeding, but the complication rate is relatively lower in the long term, and the patients have better long-term hip function recovery, so total hip arthroplasty is recommended for patients with femoral neck fracture with an expected survival time longer than 3 years.

[Anatomy study of MGA in Chinese and its effect on legal expertise].

OBJECTIVE: This study aimed to clarify the morphology of the Martin-Gruber anastomosis (MGA) in Chinese. METHODS: One hundred and five Chinese upper limbs (36 males and 20 femalese) were dissected to find the connections between medial nerve and ulnar nerve. The MGA was classified as previously described by Lee. RESULTS: MGA was found in 24 cases (22.9%), in 11 of the 36 male and 5 of the 20 female. There was no obvious difference in the frequency of MGA in both upper limbs. Most MGA ulnar position was located at the medial and distal segment of the forearm. CONCLUSION: MGA anatomy could play important role in forensic diagnosis of ulnar nerve injury in Chinese population.

[Estimation of postmortem interval using myofibril fragmentation index].

OBJECTIVE: To study the relationship between postmortem interval and the myofibril fragmentation index of skeletal muscle. METHODS: Rabbit skeletal muscle were left in the room temperature for different postmortem intervals, and the protein concentration of each sample was detected by using biuret method. Furthermore, the myofibril fragmentation index of each sample was measured under the protein concentration level of 0.5 mg/mL. RESULTS: The myofibril fragmentation index increased obviously according to the postmortem interval prolongation. CONCLUSION: The myofibril fragmentation index may be used on the estimation of early postmortem interval.

[Study of CTnI immunohistochemistry on acute myocardial infarction in rabbits].

OBJECTIVE: To investigate the signification of CTnI in acute myocardial infarction. METHODS: The model of myocardial infarction was established by ligating the left ventricle branch. Immunohistochemistry and image analysis were used to detect the change of CTnI in the model, and The sensitivity of immunohistochemistry and HE coloration were also compared. RESULTS: The acute myocardial infarction tissue showed obvious depletion of CTnI, there was no characterization of myocardial infarction in HE coloration. CONCLUSION: CTnI is sensitive to diagnosis of acute myocardial infarction.

Immunohistochemical analysis of cardiac troponin inhibitor in an experimental model of acute myocardial infarction experimental model and in human tissues.

Acute obstruction of coronary arteries leads to acute myocardial infarction (AMI), which causes unexpected death in humans. However, AMI cannot be easily detected in forensic examinations with traditional hematoxylin and eosin (H&E) staining. We analyzed whether cardiac troponin inhibitor (CTnI) could serve as a sensitive and specific early marker for diagnosing AMI in forensic medicine. We established an AMI model in rabbits by ligating the left ventricular branch and observed CTnI expression with immunohistochemistry after different ligation times. We found increased CTnI staining at the 0.5-h time point and depletion of CTnI staining with a 1-h ligation. The areas in which CTnI staining was depleted as seen with immunohistochemical analysis were consistent with the results of H&E staining. Next, human myocardium tissues from 30 persons who died from AMI and were subsequently examined in our forensic center were studied using immunohistochemistry with an antibody to human CTnI. Areas of infarction also showed depletion of CTnI staining. These findings suggested that immunohistochemical detection of CTnI is earlier, more sensitive, and myocardial tissue - specific as compared with H&E staining. CTnI may serve as an ideal marker for diagnosing AMI in forensic investigations.