ABSTRACT
The effect of reamberin (1.5% solution of succinic acid and ion complex) on the oxygenation status of the brain was studied in children aged 1 - 14 years during recovery from anesthesia. It is established that reamberin in a dose of 2 ml/kg administered twice at the end of an operation increases the fraction of oxidized hemoglobin and cytochrome oxidase and enhances the regional saturation of brain tissue with oxygen, which is indicative of an increase in the potential of metabolism activation in neurons.
Subject(s)
Brain/drug effects , Meglumine/analogs & derivatives , Neurons/drug effects , Oxygen Consumption/drug effects , Oxygen/metabolism , Succinates/administration & dosage , Adolescent , Anesthesia , Anesthesia Recovery Period , Anesthetics/administration & dosage , Brain/metabolism , Child , Child, Preschool , Drug Administration Schedule , Electron Transport Complex IV/biosynthesis , Humans , Infant , Injections, Intravenous , Male , Meglumine/administration & dosage , Meglumine/therapeutic use , Neurons/metabolism , Oxidation-Reduction , Oxyhemoglobins/biosynthesis , Succinates/therapeutic use , Succinic Acid/chemistryABSTRACT
The possibility of using 1.5% succinic acid solution (reamberin) in order to activate recovery from anesthesia was studied in a group of 91 patients aged 1-14 years. Based on clinical data and BIS-index, it is established that the administration of reamberin during exit from anesthesia stage shortens the wake-up period, decreases the time of restoration of the motor activity and adequate respiration, and accelerates brain function recovery.