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1.
Novel conversion of 1,2-disubstituted cis-epoxides to one-carbon homologated allylic alcohols using dimethylsulfonium methylide.
Alcaraz, L; Cridland, A; Kinchin, E.
Org Lett ; 3(25): 4051-3, 2001 Dec 13.
Article in English | MEDLINE | ID: mdl-11735582

ABSTRACT

[reaction: see text] The treatment of cis-epoxides with an excess of dimethylsulfonium methylide affords one-carbon homologated allylic alcohols in good to excellent yields.

2.
Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues.
Bonnert, R V; Brown, R C; Chapman, D; Cheshire, D R; Dixon, J; Ince, F; Kinchin, E C; Lyons, A J; Davis, A M; Hallam, C; Harper, S T; Unitt, J F; Dougall, I G; Jackson, D M; McKechnie, K; Young, A; Simpson, W T.
J Med Chem ; 41(25): 4915-7, 1998 Dec 03.
Article in English | MEDLINE | ID: mdl-9836607

Subject(s)
Adrenergic beta-2 Receptor Agonists , Adrenergic beta-Agonists/chemical synthesis , Anti-Asthmatic Agents/chemical synthesis , Dopamine Agonists/chemical synthesis , Lung Diseases, Obstructive/drug therapy , Receptors, Dopamine D2/agonists , Thiazoles/chemical synthesis , Adrenergic beta-Agonists/pharmacology , Animals , Anti-Asthmatic Agents/pharmacology , Bronchoconstriction/drug effects , Dogs , Dopamine Agonists/pharmacology , Drug Evaluation, Preclinical , Ear/blood supply , In Vitro Techniques , Mucus/drug effects , Rabbits , Respiration/drug effects , Thiazoles/pharmacology , Vasoconstriction/drug effects
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