ABSTRACT
Under the influence of microwaves is migration of chemical and metals used in manufacture for these furnaces. This confirms the need for research to develop modes of training materials used in the manufacture of utensils used in microwave ovens.
Subject(s)
Food Packaging , Food , Microwaves , Models, ChemicalABSTRACT
Analysis of the medical records of 122 patients with nodular polyarteritis showed that the most frequent visceral manifestations were renal (93.4%), cardial (72%), and gastrointestinal (57.4%) ones. Central nervous system (CNS), pulmonary, and peripheral arterial lesions were less frequent (36.8%, 17.2%, and 6.6%, respectively). Renal lesions were manifested by arterial hypertension (AH) in 107 patients, urinary syndrome in 97, nephrotic syndrome in 7, and rapidly progressing glomerulonephritis in 5 patients. Monofactor analysis revealed the following predictors of poor prognosis: malignant AH, nephrotic proteinuria, male sex, body mass reduction, intestinal ulcers, gastrointestinal hemorrhage, CNS lesion, heart failure, and pulmonary lesion. The relative risk of lethal outcome was the highest in nephrotic proteinuria (3.5) and malignant AH (2.9). In 56% of cases death was caused by cardiovascular complications, in 18%--chronic renal failure, in 11%--abdominal complications.
Subject(s)
Kidney Diseases/etiology , Polyarteritis Nodosa/complications , Acute Kidney Injury/etiology , Adult , Cardiovascular Diseases/etiology , Cardiovascular Diseases/mortality , Central Nervous System Diseases/etiology , Gastrointestinal Diseases/etiology , Humans , Hypertension, Renal/etiology , Kidney Failure, Chronic/etiology , Lung Diseases/diagnostic imaging , Lung Diseases/etiology , Male , Nephrotic Syndrome/etiology , Polyarteritis Nodosa/mortality , Polyarteritis Nodosa/therapy , Prognosis , Radiography, Thoracic , Risk , Sex FactorsABSTRACT
Previous studies have demonstrated functional roles for microRNAs (miRNAs) in various aspects of normal and malignant hematopoiesis, including lineage commitment, differentiation, apoptosis and maturation. In vivo delivery of naked DNA, oligonucleotides and miRNAs is complicated by their low stability, rapid degradation and inefficient delivery into target cells. In our experiments, we used a new type of polymer carriers to monitor the effects of miR-155 and antago-miR-155 on the morphology and genetics of Kasumi-1 cells. We obtained platelet-like cells from leukemic cells, and detected the expression of platelet marker genes after transfection with antago-miR-155. Our findings suggest that administration of miR mimics or antago-miRs as therapeutic agents is a desirable goal for future treatment of hematologic malignancies and that polymer-based carriers for the delivery of miR mimics or antago-miRs may provide a solution to the challenges of standard miR delivery approaches.