Search | VHL CLAP/WR-PAHO/WHO

1.

Discovery of Red-Shifting Mutations in Firefly Luciferase Using High-Throughput Biochemistry.

Colee, Clair M; Oberlag, Nicole M; Simon, Marcell; Chapman, Owen S; Flanagan, Lyndsey C; Reid-McLaughlin, Edison S; Gewing-Mullins, Jordan A; Maiche, Synaida; Patel, Devi F; Cavalcanti, Andre R O; Leconte, Aaron M.

Biochemistry ; 63(6): 733-742, 2024 Mar 19.

Article in English | MEDLINE | ID: mdl-38437583

2.

Biochemical Analysis Leads to Improved Orthogonal Bioluminescent Tools.

Williams, Sierra J; Gewing-Mullins, Jordan A; Lieberman, Whitney K; Kolbaba-Kartchner, Bethany; Iqbal, Reema; Burgess, Hana M; Colee, Clair M; Ornelas, Marya Y; Reid-McLaughlin, Edison S; Mills, Jeremy H; Prescher, Jennifer A; Leconte, Aaron M.

Chembiochem ; 24(6): e202200726, 2023 03 14.

Article in English | MEDLINE | ID: mdl-36592373

3.

Accurate and Efficient One-Pot Reverse Transcription and Amplification of 2'-Fluoro-Modified Nucleic Acids by Commercial DNA Polymerases.

Thompson, Arianna S; Barrett, Susanna E; Weiden, Aurora G; Venkatesh, Ananya; Seto, Madison K C; Gottlieb, Simone Z P; Leconte, Aaron M.

Biochemistry ; 59(31): 2833-2841, 2020 08 11.

Article in English | MEDLINE | ID: mdl-32659079

4.

Statistical Coupling Analysis-Guided Library Design for the Discovery of Mutant Luciferases.

Liu, Mira D; Warner, Elliot A; Morrissey, Charlotte E; Fick, Caitlyn W; Wu, Taia S; Ornelas, Marya Y; Ochoa, Gabriela V; Zhang, Brendan S; Rathbun, Colin M; Porterfield, William B; Prescher, Jennifer A; Leconte, Aaron M.

Biochemistry ; 57(5): 663-671, 2018 02 06.

Article in English | MEDLINE | ID: mdl-29224332

5.

Design and Discovery of New Combinations of Mutant DNA Polymerases and Modified DNA Substrates.

Rosenblum, Sydney L; Weiden, Aurora G; Lewis, Eliza L; Ogonowsky, Alexie L; Chia, Hannah E; Barrett, Susanna E; Liu, Mira D; Leconte, Aaron M.

Chembiochem ; 18(8): 816-823, 2017 04 18.

Article in English | MEDLINE | ID: mdl-28160372

6.

Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution.

Dickinson, Bryan C; Leconte, Aaron M; Allen, Benjamin; Esvelt, Kevin M; Liu, David R.

Proc Natl Acad Sci U S A ; 110(22): 9007-12, 2013 May 28.

Article in English | MEDLINE | ID: mdl-23674678

7.

Taq DNA Polymerase Mutants and 2'-Modified Sugar Recognition.

Schultz, Hayley J; Gochi, Andrea M; Chia, Hannah E; Ogonowsky, Alexie L; Chiang, Sharon; Filipovic, Nedim; Weiden, Aurora G; Hadley, Emma E; Gabriel, Sara E; Leconte, Aaron M.

Biochemistry ; 54(38): 5999-6008, 2015 Sep 29.

Article in English | MEDLINE | ID: mdl-26334839

8.

Discovery and biological characterization of geranylated RNA in bacteria.

Dumelin, Christoph E; Chen, Yiyun; Leconte, Aaron M; Chen, Y Grace; Liu, David R.

Nat Chem Biol ; 8(11): 913-9, 2012 Nov.

Article in English | MEDLINE | ID: mdl-22983156

9.

A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes.

Leconte, Aaron M; Dickinson, Bryan C; Yang, David D; Chen, Irene A; Allen, Benjamin; Liu, David R.

Biochemistry ; 52(8): 1490-9, 2013 Feb 26.

Article in English | MEDLINE | ID: mdl-23360105

10.

Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase.

Duyzend, Michael H; Clark, Christopher T; Simmons, Shayna L; Johnson, Wade B; Larson, Anna M; Leconte, Aaron M; Wills, Andrew W; Ginder-Vogel, Matthew; Wilhelm, April K; Czechowicz, Josephine A; Alberg, David G.

J Enzyme Inhib Med Chem ; 27(6): 784-94, 2012 Dec.

Article in English | MEDLINE | ID: mdl-22085139

11.

Mutant polymerases capable of 2' fluoro-modified nucleic acid synthesis and amplification with improved accuracy.

Christensen, Trevor A; Lee, Kristi Y; Gottlieb, Simone Z P; Carrier, Mikayla B; Leconte, Aaron M.

RSC Chem Biol ; 3(8): 1044-1051, 2022 Aug 03.

Article in English | MEDLINE | ID: mdl-35975008

12.

Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet.

Leconte, Aaron M; Hwang, Gil Tae; Matsuda, Shigeo; Capek, Petr; Hari, Yoshiyuki; Romesberg, Floyd E.

J Am Chem Soc ; 130(7): 2336-43, 2008 Feb 20.

Article in English | MEDLINE | ID: mdl-18217762

13.

Chemical biology: a broader take on DNA.

Leconte, Aaron M; Romesberg, Floyd E.

Nature ; 444(7119): 553-5, 2006 Nov 30.

Article in English | MEDLINE | ID: mdl-17136078

14.

DNA Polymerase Activity Assay Using Near-infrared Fluorescent Labeled DNA Visualized by Acrylamide Gel Electrophoresis.

Lewis, Eliza L; Leconte, Aaron M.

J Vis Exp ; (128)2017 10 06.

Article in English | MEDLINE | ID: mdl-29053685

15.

Directed evolution of DNA polymerases for next-generation sequencing.

Leconte, Aaron M; Patel, Maha P; Sass, Lauryn E; McInerney, Peter; Jarosz, Mirna; Kung, Li; Bowers, Jayson L; Buzby, Philip R; Efcavitch, J William; Romesberg, Floyd E.

Angew Chem Int Ed Engl ; 49(34): 5921-4, 2010 Aug 09.

Article in English | MEDLINE | ID: mdl-20629059

16.

Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication.

Hari, Yoshiyuki; Hwang, Gil Tae; Leconte, Aaron M; Joubert, Nicolas; Hocek, Michal; Romesberg, Floyd E.

Chembiochem ; 9(17): 2796-9, 2008 Nov 24.

Article in English | MEDLINE | ID: mdl-19012285

17.

Efforts towards expansion of the genetic alphabet: pyridone and methyl pyridone nucleobases.

Leconte, Aaron M; Matsuda, Shigeo; Hwang, Gil Tae; Romesberg, Floyd E.

Angew Chem Int Ed Engl ; 45(26): 4326-9, 2006 Jun 26.

Article in English | MEDLINE | ID: mdl-16733840

18.

Stability and polymerase recognition of pyridine nucleobase analogues: role of minor-groove H-bond acceptors.

Kim, Yoonkyung; Leconte, Aaron M; Hari, Yoshiyuki; Romesberg, Floyd E.

Angew Chem Int Ed Engl ; 45(46): 7809-12, 2006 Nov 27.

Article in English | MEDLINE | ID: mdl-17075934

19.

Polymerase recognition and stability of fluoro-substituted pyridone nucleobase analogues.

Hwang, Gil Tae; Leconte, Aaron M; Romesberg, Floyd E.

Chembiochem ; 8(13): 1606-11, 2007 Sep 03.

Article in English | MEDLINE | ID: mdl-17647205

20.

Minor groove hydrogen bonds and the replication of unnatural base pairs.

Matsuda, Shigeo; Leconte, Aaron M; Romesberg, Floyd E.

J Am Chem Soc ; 129(17): 5551-7, 2007 May 02.

Article in English | MEDLINE | ID: mdl-17411040

VHL CLAP/WR-PAHO/WHO

Latin-American Center for Perinatology, Woman and Reproductive Health

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