Attentional bias towards interpersonal aggression in depression - an eye movement study.

Depressed individuals exhibit an attentional bias towards mood-congruent stimuli, yet evidence for biased processing of threat-related information in human interaction remains scarce. Here, we tested whether an attentional bias towards interpersonally aggressive pictures over interpersonally neutral pictures could be observed to a greater extent in depressed participants than in control participants. Eye movements were recorded while the participants freely viewed visually matched interpersonally aggressive and neutral pictures, which were presented in pairs. Across the groups, participants spent more time looking at neutral pictures than at aggressive pictures, probably reflecting avoidance behavior. When the participants could anticipate the stimulus valence, depressed participants - but not controls - showed an early attentional bias towards interpersonally aggressive pictures, as indexed by their longer first fixation durations on aggressive pictures than on neutral pictures. Our results thus preliminarily suggest both an early attentional bias towards interpersonal aggression, which is present, in depressed participants, also when aggression contents are anticipated, and a later attentional avoidance of aggression. The early depression-related bias in information processing may have maladaptive effects on the way depressed individuals perceive and function in social interaction and can, therefore, maintain depressed mood.

Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History: Evidence from Monozygotic Twins.

Associations between long-term physical activity and cortical function and brain structure are poorly known. Our aim was to assess whether brain functional and/or structural modulation associated with long-term physical activity is detectable using a discordant monozygotic male twin pair design. Nine monozygotic male twin pairs were carefully selected for an intrapair difference in their leisure-time physical activity of at least three years duration (mean age 34 ± 1 years). We registered somatosensory mismatch response (SMMR) in EEG to electrical stimulation of fingers and whole brain MR images. We obtained exercise history and measured physical fitness and body composition. Equivalent electrical dipole sources of SMMR as well as gray matter (GM) voxel counts in regions of interest indicated by source analysis were evaluated. SMMR dipolar source strengths differed between active and inactive twins within twin pairs in postcentral gyrus, medial frontal gyrus and superior temporal gyrus and in anterior cingulate (AC) GM voxel counts differed similarly. Compared to active twins, their inactive twin brothers showed greater dipole strengths in short periods of the deviant-elicited SMMR and larger AC GM voxel counts. Stronger activation in early unattended cortical processing of the deviant sensory signals in inactive co-twins may imply less effective gating of somatosensory information in inactive twins compared to their active brothers. Present findings indicate that already in 30's long-term physical activity pattern is linked with specific brain indices, both in functional and structural domains.

On the Eye Movement Control of Changing Reading Direction for a Single Word: The Case of Reading Numerals in Urdu.

Typically orthographies are consistent in terms of reading direction, i.e. from left-to-right or right-to-left. However, some are bidirectional, i.e., certain parts of the text, (such as numerals in Urdu), are read against the default reading direction. Such sudden changes in reading direction may challenge the reader in many ways, at the level of planning of saccadic eye movements, changing the direction of attention, word recognition processes and cognitive reading strategies. The present study attempts to understand how readers achieve such sudden changes in reading direction at the level of eye movements and conscious cognitive reading strategies. Urdu readers reported employing a two-stage strategy for reading numerals by first counting the number of digits during right-to-left fixations, and only then forming numeric representation during left-to-right fixations. Eye movement findings were aligned with this strategy usage, as long numerals were often read with deliberate forward-and-backward fixation sequences. In these sequences fixations preceding saccades to default reading direction were shorter than against it, suggesting that different cognitive processes such as counting and formation of numeric representation were involved in fixations preceding left- and right-directed saccades. Finally, the change against the default reading direction was preceded by highly inflated fixation duration, pinpointing the oculomotor, attentional and cognitive demands in executing sudden changes in reading direction.

Auditory P3a response to native and foreign speech in children with or without attentional deficit.

The aim of this study was to investigate the attentional mechanism in speech processing of native and foreign language in children with and without attentional deficit. For this purpose, the P3a component, cognitive neuromarker of the attentional processes, was investigated in a two-sequence two-deviant oddball paradigm using Finnish and English speech items via event-related potentials (ERP) technique. The difference waves reflected the temporal brain dynamics of the P3a response in native and foreign language contexts. Cluster-based permutation tests evaluated the group differences over the P3a time window. A correlation analysis was conducted between the P3a response and the attention score (ATTEX) to evaluate whether the behavioral assessment reflected the neural activity. The source reconstruction method (CLARA) was used to investigate the neural origins of the attentional differences between groups and conditions. The ERP results showed a larger P3a response in the group of children with attentional problems (AP) compared to controls (CTR). The P3a response differed statistically between the two groups in the native language processing, but not in the foreign language. The ATTEX score correlated with the P3a amplitude in the native language contrasts. The correlation analyses hint at some hemispheric brain activity difference in the frontal area. The group-level CLARA reconstruction showed activation in the speech perception and attention networks over the frontal, parietal, and temporal areas. Differences in activations of these networks were found between the groups and conditions, with the AP group showing higher activity in the source level, being the origin of the ERP enhancement observed on the scalp level.

Brain Source Correlates of Speech Perception and Reading Processes in Children With and Without Reading Difficulties.

Neural correlates in reading and speech processing have been addressed extensively in the literature. While reading skills and speech perception have been shown to be associated with each other, their relationship remains debatable. In this study, we investigated reading skills, speech perception, reading, and their correlates with brain source activity in auditory and visual modalities. We used high-density event-related potentials (ERPs), fixation-related potentials (FRPs), and the source reconstruction method. The analysis was conducted on 12-13-year-old schoolchildren who had different reading levels. Brain ERP source indices were computed from frequently repeated Finnish speech stimuli presented in an auditory oddball paradigm. Brain FRP source indices were also computed for words within sentences presented in a reading task. The results showed significant correlations between speech ERP sources and reading scores at the P100 (P1) time range in the left hemisphere and the N250 time range in both hemispheres, and a weaker correlation for visual word processing N170 FRP source(s) in the posterior occipital areas, in the vicinity of the visual word form areas (VWFA). Furthermore, significant brain-to-brain correlations were found between the two modalities, where the speech brain sources of the P1 and N250 responses correlated with the reading N170 response. The results suggest that speech processes are linked to reading fluency and that brain activations to speech are linked to visual brain processes of reading. These results indicate that a relationship between language and reading systems is present even after several years of exposure to print.

Discriminatory Brain Processes of Native and Foreign Language in Children with and without Reading Difficulties.

The association between impaired speech perception and reading difficulty has been well established in native language processing, as can be observed from brain activity. However, there has been scarce investigation of whether this association extends to brain activity during foreign language processing. The relationship between reading skills and neuronal speech representation of foreign language remains unclear. In the present study, we used event-related potentials (ERPs) with high-density EEG to investigate this question. Eleven- to 13-year-old children typically developed (CTR) or with reading difficulties (RD) were tested via a passive auditory oddball paradigm containing native (Finnish) and foreign (English) speech items. The change-detection-related ERP responses, the mismatch response (MMR), and the late discriminative negativity (LDN) were studied. The cluster-based permutation tests within and between groups were performed. The results showed an apparent language effect. In the CTR group, we found an atypical MMR in the foreign language processing and a larger LDN response for speech items containing a diphthong in both languages. In the RD group, we found unstable MMR with lower amplitude and a nonsignificant LDN response. A deficit in the LDN response in both languages was found within the RD group analysis. Moreover, we observed larger brain responses in the RD group and a hemispheric polarity reversal compared to the CTR group responses. Our results provide new evidence that language processing differed between the CTR and RD groups in early and late discriminatory responses and that language processing is linked to reading skills in both native and foreign language contexts.

Attentional Processes in Children With Attentional Problems or Reading Difficulties as Revealed Using Brain Event-Related Potentials and Their Source Localization.

Visual attention-related processes include three functional sub-processes: alerting, orienting, and inhibition. We examined these sub-processes using reaction times, event-related potentials (ERPs), and their neuronal source activations during the Attention Network Test (ANT) in control children, attentional problems (AP) children, and reading difficulties (RD) children. During the ANT, electroencephalography was measured using 128 electrodes on three groups of Finnish sixth-graders aged 12-13 years (control = 77; AP = 15; RD = 23). Participants were asked to detect the direction of a middle target fish within a group of five fish. The target stimulus was either preceded by a cue (center, double, or spatial), or without a cue, to manipulate the alerting and orienting sub-processes of attention. The direction of the target fish was either congruent or incongruent in relation to the flanker fish, thereby manipulating the inhibition sub-processes of attention. Reaction time performance showed no differences between groups in alerting, orienting, and inhibition effects. The group differences in ERPs were only found at the source level. Neuronal source analysis in the AP children revealed a larger alerting effect (double-cued vs. non-cued target stimuli) than control and RD children in the left occipital lobe. Control children showed a smaller orienting effect (spatially cued vs. center-cued target stimuli) in the left occipital lobe than AP and RD children. No group differences were found for the neuronal sources related to the inhibition effect. The neuronal activity differences related to sub-processes of attention in the AP and RD groups suggest different underlying mechanisms for attentional and reading problems.

Attentional processes in typically developing children as revealed using brain event-related potentials and their source localization in Attention Network Test.

Attention-related processes include three functional sub-components: alerting, orienting, and inhibition. We investigated these components using EEG-based, brain event-related potentials and their neuronal source activations during the Attention Network Test in typically developing school-aged children. Participants were asked to detect the swimming direction of the centre fish in a group of five fish. The target stimulus was either preceded by a cue (centre, double, or spatial) or no cue. An EEG using 128 electrodes was recorded for 83 children aged 12-13 years. RTs showed significant effects across all three sub-components of attention. Alerting and orienting (responses to double vs non-cued target stimulus and spatially vs centre-cued target stimulus, respectively) resulted in larger N1 amplitude, whereas inhibition (responses to incongruent vs congruent target stimulus) resulted in larger P3 amplitude. Neuronal source activation for the alerting effect was localized in the right anterior temporal and bilateral occipital lobes, for the orienting effect bilaterally in the occipital lobe, and for the inhibition effect in the medial prefrontal cortex and left anterior temporal lobe. Neuronal sources of ERPs revealed that sub-processes related to the attention network are different in children as compared to earlier adult fMRI studies, which was not evident from scalp ERPs.

Influence of reading skill and word length on fixation-related brain activity in school-aged children during natural reading.

Word length is one of the main determinants of eye movements during reading and has been shown to influence slow readers more strongly than typical readers. The influence of word length on reading in individuals with different reading skill levels has been shown in separate eye-tracking and electroencephalography studies. However, the influence of reading difficulty on cortical correlates of word length effect during natural reading is unknown. To investigate how reading skill is related to brain activity during natural reading, we performed an exploratory analysis on our data set from a previous study, where slow reading (N = 27) and typically reading (N = 65) 12-to-13.5-year-old children read sentences while co-registered ET-EEG was recorded. We extracted fixation-related potentials (FRPs) from the sentences using the linear deconvolution approach. We examined standard eye-movement variables and deconvoluted FRP estimates: intercept of the response, categorical effect of first fixation versus additional fixation and continuous effect of word length. We replicated the pattern of stronger word length effect in eye movements for slow readers. We found a difference between typical readers and slow readers in the FRP intercept, which contains activity that is common to all fixations, within a fixation time-window of 50-300 ms. For both groups, the word length effect was present in brain activity during additional fixations; however, this effect was not different between groups. This suggests that stronger word length effect in the eye movements of slow readers might be mainly due re-fixations, which are more probable due to the lower efficiency of visual processing.

A co-registration investigation of inter-word spacing and parafoveal preview: Eye movements and fixation-related potentials.

Participants' eye movements (EMs) and EEG signal were simultaneously recorded to examine foveal and parafoveal processing during sentence reading. All the words in the sentence were manipulated for inter-word spacing (intact spaces vs. spaces replaced by a random letter) and parafoveal preview (identical preview vs. random letter string preview). We observed disruption for unspaced text and invalid preview conditions in both EMs and fixation-related potentials (FRPs). Unspaced and invalid preview conditions received longer reading times than spaced and valid preview conditions. In addition, the FRP data showed that unspaced previews disrupted reading in earlier time windows of analysis, compared to string preview conditions. Moreover, the effect of parafoveal preview was greater for spaced relative to unspaced conditions, in both EMs and FRPs. These findings replicate well-established preview effects, provide novel insight into the neural correlates of reading with and without inter-word spacing and suggest that spatial selection precedes lexical processing.

Parafoveal previews and lexical frequency in natural reading: Evidence from eye movements and fixation-related potentials.

Participants' eye movements and electroencephalogram (EEG) signal were recorded as they read sentences displayed according to the gaze-contingent boundary paradigm. Two target words in each sentence were manipulated for lexical frequency (high vs. low frequency) and parafoveal preview of each target word (identical vs. string of random letters vs. string of Xs). Eye movement data revealed visual parafoveal-on-foveal (PoF) effects, as well as foveal visual and orthographic preview effects and word frequency effects. Fixation-related potentials (FRPs) showed visual and orthographic PoF effects as well as foveal visual and orthographic preview effects. Our results replicated the early preview positivity effect (Dimigen, Kliegl, & Sommer, 2012) in the X-string preview condition, and revealed different neural correlates associated with a preview comprised of a string of random letters relative to a string of Xs. The former effects seem likely to reflect difficulty associated with the integration of parafoveal and foveal information, as well as feature overlap, while the latter reflect inhibition, and potentially disruption, to processing underlying reading. Interestingly, and consistent with Kretzschmar, Schlesewsky, and Staub (2015), no frequency effect was reflected in the FRP measures. The findings provide insight into the neural correlates of parafoveal processing and written word recognition in reading and demonstrate the value of utilizing ecologically valid paradigms to study well established phenomena that occur as text is read naturally. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

Semantic anomaly detection in school-aged children during natural sentence reading - A study of fixation-related brain potentials.

In this study, we investigated the effects of context-related semantic anomalies on the fixation-related brain potentials of 12-13-year-old Finnish children in grade 6 during sentence reading. The detection of such anomalies is typically reflected in the N400 event-related potential. We also examined whether the representation invoked by the sentence context extends to the orthographic representation level by replacing the final words of the sentence with an anomalous word neighbour of a plausible word. The eye-movement results show that the anomalous word neighbours of plausible words cause similar first-fixation and gaze duration reactions, as do other anomalous words. Similarly, we observed frontal negativity in the fixation-related potential of the unrelated anomalous words and in the anomalous word neighbours. This frontal negativity was larger in both anomalous conditions than in the response elicited by the plausible condition. We thus show that the brain successfully uses context to separate anomalous words from plausible words on a single letter level during free reading. From the P600 response of the scalp waveform, we observed that the P600 was delayed in the anomalous word neighbour condition. We performed group-level decomposition on the data with ICA (independent component analysis) and analysed the time course and source structure of the decomposed data. This analysis of decomposed brain signals not only confirmed the delay of the P600 response but also revealed that the frontal negativity concealed s more typical and separate N400 response, which was similarly delayed in the anomalous word neighbour condition, as was the P600 response. Source analysis of these independent components implicated the right frontal eye field as the cortical source for the frontal negativity and the middle temporal and parietal regions as cortical sources for the components resembling the N400 and P600 responses. We interpret the delays present in N400 and P600 responses to anomalous word neighbours to reflect competition with the representation of the plausible word just one letter different.

Brain event-related potentials to phoneme contrasts and their correlation to reading skills in school-age children.

Development of reading skills has been shown to be tightly linked to phonological processing skills and to some extent to speech perception abilities. Although speech perception is also known to play a role in reading development, it is not clear which processes underlie this connection. Using event-related potentials (ERPs) we investigated the speech processing mechanisms for common and uncommon sound contrasts (/ba/-/da/-/ga/ and /ata/-/at:a/) with respect to the native language of school-age children in Finland and the United States. In addition, a comprehensive behavioral test battery of reading and phonological processing was administered. ERPs revealed that the children could discriminate between the speech sound contrasts (place of articulation and phoneme length) regardless of their native language. No differences emerged between the Finnish and US children in their change detection responses. However, the brain responses to the phoneme length contrast correlated robustly with reading scores in the US children with larger responses being linked to poorer reading skills. Finnish children also showed correlations between the reading and phonological measures and ERP responses, but the pattern of results was not as clear as for the US children. The results indicate that speech perception is linked to reading skills and this link is more robust for uncommon speech sound contrasts.