ABSTRACT
Differences in handgun bullet diameter, expansion, and penetration (no exit) versus perforation (with exit) may be the cause of variable blood pressure effects after thoracopulmonary injury. Forty nonlethal isolated gunshot wounds of the thorax were evaluated excluding wounds of the heart, great vessels, and spinal cord. Chest radiographs were assessed for bullet base diameter, bullet expansion, and wound length. Large bullets were defined as having radiographic base images of 9 mm or more in diameter. Systolic blood pressures were compared between penetrating large and small bullet groups and with perforating wounds. Response times and demographics were compared. Wounds caused by large bullet penetration resulted in lower initial systolic blood pressures than wounds caused by small bullet penetration (98 vs 125 mm Hg, P < 0.05). The average age, transport time, and wound length were similar among the bullet groups. We conclude that penetrating thoracopulmonary wounds caused by large bullets resulted in lower initial systolic blood pressure.
Subject(s)
Hypotension/etiology , Hypotension/physiopathology , Radiography, Thoracic/methods , Thoracic Injuries/complications , Thoracic Injuries/diagnostic imaging , Wounds, Gunshot/complications , Wounds, Gunshot/diagnostic imaging , Adolescent , Adult , Biomechanical Phenomena , Blood Pressure , Hemodynamics , Humans , Middle Aged , Retrospective Studies , Systole , Time Factors , TriageABSTRACT
In a study of postmortem ethanol concentrations, blood was withdrawn from the right atrium, ascending aorta, and inferior vena cava. These samples, vitreous humor, and gastric fluid were analyzed in 307 autopsies, where a minimum blood ethanol concentration of 0.05% weight/volume (w/v) was present. Premortem, agonal, and postmortem events were reviewed in an attempt to account for differences in blood ethanol concentrations between sites. The agonal aspiration of vomitus having at least 0.80% w/v ethanol appears to be associated with an increase in aortic ethanol concentrations. We conclude that valid interpretation of postmortem ethanol concentrations must take into consideration the possible entry of ethanol into the pulmonary venous circulation via the respiratory system.
Subject(s)
Alcoholic Intoxication/diagnosis , Ethanol/analysis , Postmortem Changes , Adult , Body Fluids/chemistry , Ethanol/blood , Gastric Juice/chemistry , Humans , Retrospective Studies , Vitreous Body/chemistryABSTRACT
Methyl bromide (MeBr) is used as an insecticide fumigant. Four deaths and three recent hospitalizations have resulted from exposures to MeBr in Dade County, FL. Six cases occurred during burglaries of tented houses over a nine-month period. In four lethal exposures, the symptoms of nausea, vomiting, and malaise preceded fulminant respiratory failure. Two of these also had seizures, delirium, and agitation. Serum or plasma bromide ion levels ranged from 40 to 583 mg/L. Pulmonary edema, hyaline membranes, and hemorrhagic alveolitis were present at autopsy along with varying degrees of cerebral edema. The nonlethal exposures resulted in symptoms of conjunctival irritation, headache, or nausea. Plasma bromide concentrations varied between 17.5 and 321 mg/L. Methyl bromide characteristics, use, morbidity, and mortality in Florida during the past 25 years are reviewed. Remedies for illegal entry are proposed.
Subject(s)
Hydrocarbons, Brominated/poisoning , Adolescent , Adult , Crime , Female , Florida , Forensic Medicine , Fumigation , Humans , Insecticides/poisoning , Male , Time FactorsSubject(s)
Bile Acids and Salts/biosynthesis , Carcinoma, Hepatocellular/metabolism , Cholesterol, Dietary , Liver Neoplasms/metabolism , Liver/metabolism , Acetates/metabolism , Animals , Carbon Radioisotopes , Chromatography, Gas , In Vitro Techniques , Mevalonic Acid/metabolism , Neoplasms, Experimental/metabolism , RatsSubject(s)
Death, Sudden/etiology , Sudden Infant Death/physiopathology , Child , Female , Humans , Time FactorsABSTRACT
Medical examiners frequently rely on the finding of free morphine present in postmortem specimens to assist in certifying deaths associated with narcotics. In vitro hydrolysis of morphine-3-D glucuronide (M3DG) to free morphine was studied using variable specimen pH, initial degree of specimen putrefaction, storage temperature and time, and the effectiveness of sodium fluoride (NaF) preservation. Reagent M3DG was added to opiate-free fresh blood and urine and to autopsy-derived blood specimens. Reagent bovine glucuronidase was also added to certain specimens. Freshly collected and refrigerated NaF-preserved blood produced minimal free morphine, whereas four of five autopsy blood specimens produced free morphine from M3DG. Increased storage time, temperature, and initial degree of putrefaction resulted in greater free morphine generation despite the absence of viable bacteria. Hydrolysis occurring during specimen storage can generate free morphine from M3DG and may result in erroneous conclusions in certifying narcotic deaths.
Subject(s)
Bacteria/enzymology , Morphine Derivatives/metabolism , Morphine/metabolism , Postmortem Changes , Preservatives, Pharmaceutical/pharmacology , Sodium Fluoride/pharmacology , Adolescent , Aged , Animals , Cattle , Female , Forensic Medicine , Gas Chromatography-Mass Spectrometry , Glucuronidase/metabolism , Humans , Hydrogen-Ion Concentration , Hydrolysis , In Vitro Techniques , Indicators and Reagents , Intestines/microbiology , Male , Middle Aged , Morphine/analysis , Morphine Derivatives/analysis , Specimen Handling/methods , Temperature , Time FactorsABSTRACT
A fatal case of Physalia physalis (Portuguese man-o'-war) envenomation occurred on the Florida Atlantic coast in 1987. Despite appropriate beachside first aid, the patient was conscious only several minutes before having primary respiratory arrest and, later, cardiovascular collapse that resulted in death. Discharged nematocysts were still visible on the injured stratum corneum five days after envenomation. Additional treatment maneuvers suggested by this case include testing the tentacle fragments found on the victim's skin before their removal to ensure that nematocyst firing has been counteracted. We document the first human fatality caused by P physalis envenomation.