ABSTRACT
BACKGROUND: Several studies support a strong association of Sweet syndrome (SS) with malignancy. However, only a few studies analysing the clinical features of malignancy-associated SS have been published in recent years. AIM: To retrospectively study the clinical features of SS that could predict the development of associated malignancies and to analyse the development of malignant neoplasia during long-term follow-up of patients with SS. METHODS: Clinical features of the patients diagnosed with SS syndrome between 1987 and 2013 at Bellvitge Hospital (Barcelona, Spain) were retrospectively analysed. RESULTS: In total, 138 patients were included in the study (66 male, 72 female, mean ± SD age 51.24 ± 14.11 years). SS was associated with haematological malignancy in 31 cases, infection in 23, inflammatory bowel disease in 12, inflammatory systemic disease in 8, and solid tumours in 4. It was drug-induced in 5 cases and idiopathic in 54. In four patients, an underlying haematological disease that was considered related to SS was diagnosed between 4 and 16 months after SS presentation. Variables significantly associated with malignancy in multivariate logistic regression analysis were age (OR = 1.08 for each increasing year, P = 0.01), anaemia (OR = 9.38, P = 0.001), thrombocytopenia (OR = 16.10, P < 0.01) and absence of arthralgia (OR = 11.13, P < 0.01). CONCLUSIONS: Patients with older age, anaemia or thrombocytopenia, and without arthralgia are more likely to have malignancy-associated SS. We recommend that patients with SS without clear aetiology should be followed up for at least 16 months to exclude a possible underlying haematological malignancy.
Subject(s)
Hematologic Neoplasms/etiology , Sweet Syndrome/complications , Sweet Syndrome/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Female , Follow-Up Studies , Hematologic Neoplasms/pathology , Humans , Male , Middle Aged , Retrospective Studies , Risk Factors , Spain , Sweet Syndrome/therapy , Time Factors , Young AdultSubject(s)
Drug Eruptions/etiology , Granuloma/chemically induced , Ink , Skin Ulcer/chemically induced , Tattooing/adverse effects , Adult , Diagnosis, Differential , Drug Eruptions/immunology , Drug Eruptions/pathology , Female , Foot Diseases/chemically induced , Foot Diseases/immunology , Foot Diseases/pathology , Foreign-Body Reaction/etiology , Foreign-Body Reaction/pathology , Granuloma/immunology , Granuloma/pathology , Granuloma Annulare/complications , Granuloma Annulare/pathology , Humans , Pruritus/chemically induced , Pruritus/immunology , Sarcoidosis/diagnosis , Skin Ulcer/immunology , Young AdultABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Attention Deficit and Disruptive Behavior Disorders/diagnosis , Anxiety Disorders/complications , Nasal Septum/diagnostic imaging , Biopsy , Nasal Septal Perforation/etiology , Dermatitis/drug therapy , Attention Deficit and Disruptive Behavior Disorders/psychology , Nasal Septum/pathology , Nasal Septum/surgery , Diagnosis, Differential , Combined Modality Therapy , Nasal Septal Perforation/diagnostic imaging , Nasal Septal Perforation/therapy , Aripiprazole/administration & dosageABSTRACT
No disponible
Subject(s)
Adult , Female , Humans , Granulomatous Disease, Chronic/blood , Granulomatous Disease, Chronic/chemically induced , Tattooing/adverse effects , Tattooing/trends , Disease Transmission, Infectious/classification , Skin Diseases/pathology , Sarcoidosis/diagnosis , Therapeutics/methods , Granulomatous Disease, Chronic/classification , Granulomatous Disease, Chronic/complications , Tattooing/methods , Tattooing , Disease Transmission, Infectious/prevention & control , Skin Diseases/blood , Sarcoidosis/mortality , Therapeutics/instrumentationABSTRACT
No disponible