ABSTRACT
BACKGROUND: The Delphi consensus study was carried out under the auspices of the International and Asia-Pacific Hepato-Pancreato-Biliary Associations (IHPBA-APHPBA) to develop practice guidelines for management of gallbladder cancer (GBC) globally. METHOD: GBC experts from 17 countries, spanning 6 continents, participated in a hybrid four-round Delphi consensus development process. The methodology involved email, online consultations, and in-person discussions. Sixty eight clinical questions (CQs) covering various domains related to GBC, were administered to the experts. A consensus recommendation was accepted only when endorsed by more than 75% of the participating experts. RESULTS: Out of the sixty experts invited initially to participate in the consensus process 45 (75%) responded to the invitation. The consensus was achieved in 92.6% (63/68) of the CQs. Consensus covers epidemiological aspects of GBC, early, incidental and advanced GBC management, definitions for radical GBC resections, the extent of liver resection, lymph node dissection, and definitions of borderline resectable and locally advanced GBC. CONCLUSIONS: This is the first international Delphi consensus on GBC. These recommendations provide uniform terminology and practical clinical guidelines on the current management of GBC. Unresolved contentious issues like borderline resectable/locally advanced GBC need to be addressed by future clinical studies.
Subject(s)
Consensus , Delphi Technique , Gallbladder Neoplasms , Humans , Gallbladder Neoplasms/therapy , Gallbladder Neoplasms/surgery , Cholecystectomy/standards , Lymph Node Excision/standards , Hepatectomy/standards , Treatment Outcome , Neoplasm StagingABSTRACT
We report a patient who was diagnosed sigmoid colon cancer associated with liver metastases in segment III. The patient underwent laparoscopic surgery where the sigmoid colon resection and hepatic metastasectomy were performed in a âÅone stagedâ surgical procedure. The pathological results showed moderately differentiated tubular adenocarcinoma in sigmoid colon, tubular adenocarcinoma metastases also in liver. Oncological surgical results were obtained with free edges of neoplasia, R0 Surgery, T3N0M1. After the optimal surgical results, the patient is handled by oncology for adjuvant treatment. We report here the sequence of events and a review of the literature.
Subject(s)
Adenocarcinoma/secondary , Colectomy/methods , Hepatectomy/methods , Laparoscopy , Liver Neoplasms/secondary , Metastasectomy/methods , Sigmoid Neoplasms/pathology , Adenocarcinoma/surgery , Aged , Hospitals, Public , Humans , Liver Neoplasms/surgery , Male , Peru , Sigmoid Neoplasms/surgeryABSTRACT
We report the case of a patient who had the initial diagnosis of tumor in the bile duct in the middle third. Patient presented with lost weight of 10 kilograms in two months and moderate epigastric pain, no jaundice. The patient underwent radical surgery of the bile duct with multiple freeze biopsy surgical margins, intraoperative choledochoscopy, intraoperative cholangiography and reconstruction bilioenteric anastomosis Y Roux transmesocolic, he had a great recovery and early discharge. The pathological results showed moderately differentiated tubular adenocarcinoma on the basis of an adenoma. Negatives retroperitoneal, retropancreatic, pericholedochal, lesser curvature and negative hepatic artery nodes, and extension of surgical margins free of neoplasia proximal and distal edges. R0 surgery. pT1N0Mx. Stage 1. After the optimal surgical outcomes, is managed by liver and biliary tract surgery service and medical oncology service for regular monitoring and controls. We present here the sequence of events and a review of the literature.
Subject(s)
Bile Duct Neoplasms/surgery , Bile Ducts, Intrahepatic/surgery , Cholangiocarcinoma/surgery , Bile Duct Neoplasms/diagnosis , Bile Ducts, Intrahepatic/diagnostic imaging , Cholangiocarcinoma/diagnosis , Female , Humans , Middle Aged , PeruABSTRACT
Reportamos el caso de un paciente a quien se le diagnosticó cáncer de colon sigmoides asociado a metástasis hepática en el segmento III. El paciente fue sometido a cirugía laparoscópica donde se realizó la resección de colon sigmoides y metastasectomía hepática en un solo acto quirúrgico. El resultado anátomo-patológico evidenció adenocarcinoma tubular moderadamente diferenciado en colon sigmoides, además metástasis de adenocarcinoma tubular en hígado. Se obtuvieron resultados quirúrgicos oncológicos adecuados con bordes libres de neoplasia, cirugía R0, T3N0M1 estadio IV. Después de los resultados quirúrgicos óptimos es manejado por oncología para recibir tratamiento adyuvante. Presentamos aquí la secuencia de hechos y una revisión de la literatura...
We report a patient who was diagnosed sigmoid colon cancer associated with liver metastases in segment III. The patient underwent laparoscopic surgery where the sigmoid colon resection and hepatic metastasectomy were performed in a ôone stagedõ surgical procedure. The pathological results showed moderately differentiated tubular adenocarcinoma in sigmoid colon, tubular adenocarcinoma metastases also in liver. Oncological surgical results were obtained with free edges of neoplasia, R0 Surgery, T3N0M1. After the optimal surgical results, the patient is handled by oncology for adjuvant treatment. We report here the sequence of events and a review of the literature...
Subject(s)
Humans , Male , Aged , Laparoscopy , Neoplasm Metastasis , Colonic NeoplasmsABSTRACT
Reportamos el caso de una paciente en quien se hizo el diagnóstico inicial de tumoración en vía biliar principal en su tercio medio. Paciente se presentó con baja ponderal de 10 kilogramos en 2 meses y dolor moderado en epigastrio, no ictericia. El paciente fue sometido a cirugía radical de la vía biliar con biopsia por congelación múltiple de bordes quirúrgicos, coledocoscopía intraoperatoria, colangiografía intraoperatoria y reconstrucción con anastomosis bilio-digestiva en Y de Roux transmesocólica, tuvo una recuperación sin complicaciones y alta precoz. El resultado anátomo-patológico evidenció adenocarcinoma tubular moderadamente diferenciado sobre la base de un adenoma. Carcinoma in situ sobre la base del adenoma. Ganglios retroperitoneales, retropancreáticos, pericoledocianos, curvatura menor y arteria hepática negativos. Bordes quirúrgicos y ampliación de bordes proximal y distal libres de neoplasia. Cirugía R0. pT1N0Mx. Estadio 1. Después de los resultados quirúrgicos óptimos es manejado por cirugía de hígado y vías biliares y oncología médica para seguimiento y controles periódicos. Presentamos aquí la secuencia de hechos y una revisión de la literatura...
We report the case of a patient who had the initial diagnosis of tumor in the bile duct in the middle third. Patient presented with lost weight of 10 kilograms in two months and moderate epigastric pain, no jaundice. The patient underwent radical surgery of the bile duct with multiple freeze biopsy surgical margins, intraoperative choledochoscopy, intraoperative cholangiography and reconstruction bilioenteric anastomosis Y Roux transmesocolic, he had a great recovery and early discharge. The pathological results showed moderately differentiated tubular adenocarcinoma on the basis of an adenoma. Negatives retroperitoneal, retropancreatic, pericholedochal, lesser curvature and negative hepatic artery nodes, and extension of surgical margins free of neoplasia proximal and distal edges. R0 surgery. pT1N0Mx. Stage 1. After the optimal surgical outcomes, is managed by liver and biliary tract surgery service and medical oncology service for regular monitoring and controls. We present here the sequence of events and a review of the literature...