Subject(s)
Dermatitis, Atopic/drug therapy , Dermatitis, Atopic/immunology , Desensitization, Immunologic , Immunoglobulins, Intravenous/administration & dosage , Administration, Sublingual , Adolescent , Animals , Antigens, Dermatophagoides/adverse effects , Antigens, Dermatophagoides/immunology , Child , Dermatitis, Atopic/diagnosis , Dermatitis, Atopic/physiopathology , Disease Progression , Drug Resistance , Female , Humans , Immunoglobulin E/blood , Immunoglobulins, Intravenous/adverse effects , Immunosuppressive Agents/administration & dosage , Immunosuppressive Agents/adverse effects , Male , Pyroglyphidae , Remission Induction , Young AdultABSTRACT
AIM: Steroid-sparing effect of sublingual immunotherapy (SLIT) in mono/polisensitized asthmatic children were evaluated. MATERIALS AND METHODS: Children undergoing allergen-specific SLIT between 2010 and 2014 were included. Asthma control and usage/dose of inhaled corticosteroid (ICS) in the previous year was determined. Asthma control without ICS need ≥6 months was defined as 'ICS avoidance'. RESULTS: 90 children (mean ± SD age 8.92 ± 4.17 years) were enrolled, 56.7% (n = 60) being polysensitized. Mono, 2-simultaneous and multiple-pollen-mix allergen SLIT were prescribed in 84.4, 17.8 and 7.8%, respectively. ICS was avoided in 70%, with no significant difference in mono- versus poly-sensitized patients. ICS-avoidance rates in mono-allergen, pollen-mixture and 2-simultaneous-allergen SLIT were 93.6, 83.3 and 73.7%, respectively. Longer-duration SLIT resulted in significantly more ICS-avoidance (p:0.0001). CONCLUSION: SLIT with mono/multiple-mixed/simultaneous allergens in childhood asthma resulted in retained-avoidance of ICS. Steroid-sparing effect of SLIT in polysensitized children warrants further investigation.
Subject(s)
Adrenal Cortex Hormones/therapeutic use , Asthma/therapy , Sublingual Immunotherapy/methods , Administration, Inhalation , Allergens/immunology , Asthma/immunology , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Immunization , Male , Pollen/immunology , Treatment OutcomeABSTRACT
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