Subject(s)
COVID-19/complications , Mouth Diseases/epidemiology , SARS-CoV-2/isolation & purification , Skin Diseases/epidemiology , COVID-19/diagnosis , COVID-19/immunology , COVID-19/virology , COVID-19 Nucleic Acid Testing/statistics & numerical data , Female , Foot , Hand , Humans , Male , Middle Aged , Mobile Health Units/statistics & numerical data , Mouth Diseases/etiology , Mouth Diseases/pathology , Mouth Mucosa/immunology , Mouth Mucosa/pathology , Prevalence , RNA, Viral/isolation & purification , SARS-CoV-2/immunology , Severity of Illness Index , Skin/immunology , Skin/pathology , Skin Diseases/etiology , Skin Diseases/pathology , Spain/epidemiologyABSTRACT
Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and its incidence has increased in recent decades. Most cSCCs are successfully treated by surgery, but local and distant metastases develop in approximately 5% of cases; this proportion is higher in certain forms of cSCC with high-risk factors, namely: tumor size >2cm, depth >2mm, Clark level ≥IV, perineural invasion, lymphovascular invasion, poor differentiation, certain histologic subtypes (desmoplastic or adenosquamous carcinoma, invasive Bowen disease, or a cSCC arising in areas of chronic inflammation), immunosuppression, human papillomavirus infection, high-risk anatomic location (pinna of the ear, labial mucosa), expression of certain tumor genes, and inadequate tumor resection. The latest TNM (tumor, lymph node, metastasis) classification of cSCC published by the American Joint Committee on Cancer (AJCC) in the seventh edition of its Cancer Staging Manual now incorporates several of these risk factors to improve disease staging. We review all the factors currently considered to be markers of poor prognosis in cSCC and analyze the new AJCC classification and the different treatment options for high-risk cSCC.
Subject(s)
Carcinoma, Squamous Cell/pathology , Skin Neoplasms/pathology , Alphapapillomavirus/pathogenicity , Carcinoma, Squamous Cell/classification , Carcinoma, Squamous Cell/epidemiology , Carcinoma, Squamous Cell/genetics , Carcinoma, Squamous Cell/therapy , Carcinoma, Squamous Cell/virology , Chemotherapy, Adjuvant , Genes, Neoplasm , Humans , Immunocompromised Host , Mohs Surgery , Neoplasm Invasiveness , Neoplasm Metastasis , Neoplasm Recurrence, Local/epidemiology , Neoplasm Staging , Papillomavirus Infections/epidemiology , Papillomavirus Infections/virology , Prognosis , Radiotherapy, Adjuvant , Risk , Sentinel Lymph Node Biopsy , Skin Neoplasms/classification , Skin Neoplasms/epidemiology , Skin Neoplasms/genetics , Skin Neoplasms/therapy , Skin Neoplasms/virology , Spain/epidemiology , Tumor BurdenSubject(s)
Adalimumab/therapeutic use , Dermatologic Agents/therapeutic use , Etanercept/therapeutic use , Pregnancy Complications/drug therapy , Psoriasis/drug therapy , Ustekinumab/therapeutic use , Abnormalities, Drug-Induced , Abortion, Induced , Adalimumab/adverse effects , Databases, Factual , Dermatologic Agents/adverse effects , Etanercept/adverse effects , Female , Fetal Membranes, Premature Rupture , Humans , Infant, Newborn , Male , Pregnancy , Registries , Respiratory Distress Syndrome, Newborn , Ustekinumab/adverse effectsABSTRACT
BACKGROUND AND OBJECTIVES: Treatment of mucosal vascular lesions is a challenge for dermatologists, although various approaches have proven efficacy, including surgery, sclerotherapy, intralesional injection of corticosteroids, transfixion, and laser therapy. The aim of this study was to describe the results of treatment with neodymium:yttrium-aluminum-garnet (Nd:YAG) laser in 11 patients with venous malformations and varicosities. PATIENTS AND METHODS: We describe the use of variable-pulse Nd:YAG to treat venous malformations or varicosities in the oral or genital mucosa of 8 women and 3 men seen in our hospital over a 1-year period. RESULTS: The following laser parameters were used: wavelength, 1064 nm; fluence, 100 to 200J/cm(2); spot diameter, 3 to 5mm; and pulse duration, 30 to 65 ms. The size of the lesions ranged from 5 to 30 mm. In all cases, a clearance of 75% to 100% was achieved in a single session with excellent healing and no significant side effects. CONCLUSIONS: Given its efficacy and ease of use, Nd:YAG may become a treatment of choice for mucosal vascular lesions. Comparative studies are now required to assess its potential superiority over other treatment options.
Subject(s)
Laser Therapy , Lasers, Solid-State/therapeutic use , Vascular Malformations/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Young AdultABSTRACT
BACKGROUND: Coronavirus disease 19 (COVID-19) has many manifestations, including respiratory, thrombotic, neurologic, digestive, and cutaneous ones. Cutaneous manifestations have been classified into 5 clinical patterns: acro-ischemic (pseudo-chilblain), vesicular, urticarial, maculopapular, and livedoid. Oral manifestations have also been reported, but much less frequently. PATIENTS AND METHODS: We performed a cross-sectional study in which we examined the oral mucosa of 666 patients with COVID-19 at the IFEMA field hospital in Madrid in April 2020. RESULTS: Seventy-eight patients (11.7%) had changes involving the oral mucosa. The most common were transient anterior U-shaped lingual papillitis (11.5%) accompanied or not by tongue swelling (6.6%), aphthous stomatitis (6.9%), a burning sensation in the mouth (5.3%), mucositis (3.9%), glossitis with patchy depapillation (3.9%), white tongue (1.6%), and enanthema (0.5%). Most of the patients also reported taste disturbances. CONCLUSION: COVID-19 also manifests in the oral cavity. The most common manifestations are transient U-shaped lingual papillitis, glossitis with patchy depapillation, and burning mouth syndrome. Mucositis with or without aphthous ulcers or enanthema may also be observed. Any these findings may be key clues to a diagnosis of COVID-19.
Subject(s)
Antibodies, Monoclonal/therapeutic use , Immunosuppressive Agents/therapeutic use , Interleukin-12 Subunit p40/antagonists & inhibitors , Keratoderma, Palmoplantar/drug therapy , Psoriasis/drug therapy , Adrenal Cortex Hormones/therapeutic use , Antibodies, Monoclonal/immunology , Antibodies, Monoclonal, Humanized , Antibody Specificity , Calcitriol/analogs & derivatives , Calcitriol/therapeutic use , Compassionate Use Trials , Drug Resistance , Humans , Interleukin-12 Subunit p40/immunology , Keratoderma, Palmoplantar/etiology , Male , Middle Aged , PUVA Therapy , Psoriasis/complications , Remission Induction , UstekinumabSubject(s)
Gingival Diseases/pathology , Granuloma, Giant Cell/pathology , Adult , Humans , Male , Time FactorsABSTRACT
Introducción La enfermedad por coronavirus-19 (COVID-19) se ha relacionado con múltiples síntomas: respiratorios, trombóticos, neurológicos, digestivos o cutáneos. Estos últimos se han clasificado en 5 tipos: lesiones acroisquémicas, lesiones vesiculares, erupción urticarial, exantema maculopapular o lesiones livedoides. Sin embargo, se han descrito mucho menos las alteraciones orales asociadas a la COVID-19. Pacientes y métodos Presentamos un estudio transversal realizado durante abril del 2020 en el Hospital de Campaña de IFEMA examinando la mucosa oral de 666 pacientes con COVID-19. Resultados En total, 78 pacientes (11,7%) presentaron alteraciones en la mucosa oral. La más frecuente fue papilitis lingual transitoria anterior en forma de U (11,5%) asociada o no a edema lingual (6,6%); estomatitis aftosa (6,9%), mucositis (3,9%) glositis con depapilación en parches (3,9%), boca urente (5,3%), lengua saburral (1,6%) y enantema (0,5%). La mayoría refería disgeusia asociada. Conclusión La cavidad oral se puede alterar por la enfermedad COVID-19, el edema lingual con papilitis lingual transitoria en forma de U o la glositis con depapilación en parches son los signos encontrados con mayor frecuencia, al igual que la sensación de ardor en la cavidad oral o boca urente. Otras manifestaciones orales que se pueden asociar a la COVID-19 son mucositis con o sin aftas o el enantema. Todos pueden ser signos clave para un diagnóstico de esta enfermedad (AU)
Background Coronavirus disease 19 (COVID-19) has many manifestations, including respiratory, thrombotic, neurologic, digestive, and cutaneous ones. Cutaneous manifestations have been classified into 5 clinical patterns: acro-ischemic (pseudo-chilblain), vesicular, urticarial, maculopapular, and livedoid. Oral manifestations have also been reported, but much less frequently. Patients and methods We performed a cross-sectional study in which we examined the oral mucosa of 666 patients with COVID-19 at the IFEMA field hospital in Madrid in April 2020. Results Seventy-eight patients (11.7%) had changes involving the oral mucosa. The most common were transient anterior U-shaped lingual papillitis (11.5%) accompanied or not by tongue swelling (6.6%), aphthous stomatitis (6.9%), a burning sensation in the mouth (5.3%), mucositis (3.9%), glossitis with patchy depapillation (3.9%), white tongue (1.6%), and enanthema (0.5%). Most of the patients also reported taste disturbances. Conclusion COVID-19 also manifests in the oral cavity. The most common manifestations are transient U-shaped lingual papillitis, glossitis with patchy depapillation, and burning mouth syndrome. Mucositis with or without aphthous ulcers or enanthema may also be observed. Any these findings may be key clues to a diagnosis of COVID-19 (AU)
Subject(s)
Humans , Coronavirus Infections/complications , Pandemics , Mouth Diseases/virology , Mouth Mucosa/pathology , Hospitals, Packaged , Cross-Sectional StudiesSubject(s)
Dermatitis, Occupational/etiology , Gloves, Protective/adverse effects , Hand Dermatoses/chemically induced , Latex Hypersensitivity/diagnosis , Maintenance , Phenylenediamines/adverse effects , Psoriasis/chemically induced , Rubber/adverse effects , Thiram/adverse effects , Adult , Dermatitis, Occupational/diagnosis , Dermatitis, Occupational/pathology , Diagnosis, Differential , Eczema/etiology , Hand Dermatoses/diagnosis , Hand Dermatoses/pathology , Humans , Male , Psoriasis/diagnosis , Psoriasis/pathology , Rubber/chemistry , Skin TestsSubject(s)
Dermatitis, Allergic Contact/etiology , Glycerides/adverse effects , Terpenes/adverse effects , Air , Humans , Male , Middle AgedABSTRACT
No disponible
Subject(s)
Humans , Male , Infant , Hemangioma/complications , Hemangioma , Hemangioma/drug therapy , Heart Defects, Congenital/complications , Heart Defects, Congenital , Eye Abnormalities/complications , Propranolol/therapeutic use , Radionuclide Angiography , Aorta, Thoracic/abnormalities , Aorta, Thoracic , Circle of Willis/pathology , Circle of WillisSubject(s)
Lipoblastoma/diagnosis , Lipoblastoma/surgery , Cervical Vertebrae/pathology , Child , Diagnosis, Differential , Humans , MaleABSTRACT
No disponible
Subject(s)
Humans , Dermatitis, Contact/complications , Azadirachta/adverse effects , Plant Oils/adverse effects , Clobetasol/therapeutic use , Dermatitis, Irritant/complications , Skin TestsABSTRACT
No disponible