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1.
Ann Transl Med ; 10(3): 152, 2022 Feb.
Article in English | MEDLINE | ID: mdl-35284548

ABSTRACT

Background: The number of obese people continues to increase worldwide, and obesity-related complications add to every country's health burden. Consequently, new weight-loss medications, such as glucagon-like peptide-1 receptor agonists (GLP-1RAs), are attracting increasing attention. This study sought to assess the cost effectiveness for weight loss of 4 GLP-1RAs in adult patients with obesity in the United States. Methods: Four GLP-1RA groups that received Liraglutide (1.8 mg QD), Semaglutide (1.0 mg QW), Dulaglutide (1.5 mg QW), or Exenatide (10 µg BID), and one no-treatment group were compared using a decision-tree model. All the estimated parameters were derived from published articles. Quality-adjusted life years (QALYs), costs, and incremental cost-effectiveness ratios (ICERs) were adopted as the study endpoints. We analyzed the results with the willingness-to-pay (WTP) threshold, and conducted deterministic and probabilistic sensitivity analyses. Results: The GLP-1RAs produced effective weight-loss results; however, not all the GLP-1RAs were cost effective compared to no treatment based on a WTP threshold of $195000/QALY. Among the 4 GLP-1RAs, Semaglutide provided a cost-effective strategy with an ICER of $135467/QALY. The sensitivity analyses showed that these results are reliable. Conclusions: Among the 4 GLP-1RAs, Semaglutide was the most cost-effective obesity medication.

2.
Huan Jing Ke Xue ; 27(11): 2303-8, 2006 Nov.
Article in Zh | MEDLINE | ID: mdl-17326445

ABSTRACT

Real world vehicle emission tests were conducted on two heavy-duty diesel trucks on un-loaded and loaded condition by using a portable emission measurement system. By analysis, the results indicate high fuel consumption and emission rates are concentrated on the high speed and acceleration areas of the speed-acceleration emission maps and the areas are much wider on loaded condition. The impact of load on fuel use and emissions will be highest while the vehicle is cruising or accelerating on (30 +/- 2.5) km x h(-1), which are 1.6 - 3.2 times of those on un-loaded condition. Synthetically, the comprehensive fuel consumption and CO, HC, NO(x) emission factors of truck I and truck II on loaded condition are respectively 1.6, 3.5, 1.1, 1.5 times and 1.2, 1.0, 0.9, 1.5 times of those without load. Load has greatest impact on fuel consumption and NO(x) emission and less effect on HC emission. As for the CO emission, it depends on the maintenance of the truck. It can be figured out from the results on two trucks that the impact of same load will be lower on a vehicle with lager type and more powerful engine, which means if one vehicle is loaded on its acceptable range of GVWR, fuel use and emissions caused by heavy loads could be decreased correspondingly.


Subject(s)
Air Pollutants/analysis , Motor Vehicles , Vehicle Emissions/analysis , Air Pollution/analysis , Air Pollution/prevention & control , Carbon Monoxide/analysis , Environmental Monitoring , Hydrocarbons/analysis , Nitrogen Oxides/analysis
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