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Euro Surveill ; 18(12)2013 Mar 21.
Article in English | MEDLINE | ID: mdl-23557942

ABSTRACT

We present the first fatal case of extensively drug-resistant tuberculosis (XDR-TB) in an injecting drug user (IDU) in Athens, Greece, co-infected with human immunodeficiency virus and hepatitis C virus and discuss the implications for public health. Despite immediate initiation of treatment, the patient's condition gradually deteriorated and he died 16 days after hospital admission because of multiple organ failure. The contact tracing investigation revealed no further infections among the patient's contacts.


Subject(s)
Extensively Drug-Resistant Tuberculosis/mortality , Mycobacterium tuberculosis/genetics , Outcome and Process Assessment, Health Care , Substance Abuse, Intravenous/complications , Adult , Antiretroviral Therapy, Highly Active , Coinfection , Contact Tracing , Drug Resistance, Multiple, Viral/drug effects , Extensively Drug-Resistant Tuberculosis/drug therapy , Extensively Drug-Resistant Tuberculosis/microbiology , Fatal Outcome , Greece/epidemiology , HIV Infections/complications , HIV Infections/drug therapy , Hepatitis C/complications , Hepatitis C/drug therapy , Humans , Male , Microbial Sensitivity Tests , Multivariate Analysis , Mycobacterium tuberculosis/drug effects , Mycobacterium tuberculosis/isolation & purification , Patient Compliance
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