1.
N Engl J Med
; 358(25): 2698-703, 2008 Jun 19.
Article
in English
| MEDLINE
| ID: mdl-18565862
ABSTRACT
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.