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1.
Circulation ; 142(14): 1330-1338, 2020 10 06.
Article in English | MEDLINE | ID: mdl-33017209

ABSTRACT

BACKGROUND: An internal thoracic artery graft to the left anterior descending artery is standard in coronary bypass surgery, but controversy exists on the best second conduit. The RAPCO trials (Radial Artery Patency and Clinical Outcomes) were designed to compare the long-term patency of the radial artery (RA) with that of the right internal thoracic artery (RITA) and the saphenous vein (SV). METHODS: In RAPCO-RITA (the RITA versus RA arm of the RAPCO trial), 394 patients <70 years of age (or <60 years of age if they had diabetes mellitus) were randomized to receive RA or free RITA graft on the second most important coronary target. In RAPCO-SV (the SV versus RA arm of the RAPCO trial), 225 patients ≥70 years of age (or ≥60 years of age if they had diabetes mellitus) were randomized to receive RA or SV graft. The primary outcome was 10-year graft failure. Long-term mortality was a nonpowered coprimary end point. The main analysis was by intention to treat. RESULTS: In the RA versus RITA comparison, the estimated 10-year patency was 89% for RA versus 80% for free RITA (hazard ratio for graft failure, 0.45 [95% CI, 0.23-0.88]). Ten-year patient survival estimate was 90.9% in the RA arm versus 83.7% in the RITA arm (hazard ratio for mortality, 0.53 [95% CI, 0.30-0.95]). In the RA versus SV comparison, the estimated 10-year patency was 85% for the RA versus 71% for the SV (hazard ratio for graft failure, 0.40 [95% CI, 0.15-1.00]), and 10-year patient survival estimate was 72.6% for the RA group versus 65.2% for the SV group (hazard ratio for mortality, 0.76 [95% CI, 0.47-1.22]). CONCLUSIONS: The 10-year patency rate of the RA is significantly higher than that of the free RITA and better than that of the SV. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00475488.


Subject(s)
Coronary Artery Bypass , Mammary Arteries , Mortality , Radial Artery , Vascular Patency , Adult , Aged , Disease-Free Survival , Female , Humans , Male , Middle Aged , Survival Rate
3.
Heart Lung Circ ; 26(2): 187-193, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27523460

ABSTRACT

BACKGROUND: The use of rapid-deployment aortic valve replacement (RD-AVR) has burgeoned in recent years. There are few studies comparing RD-AVR to conventional aortic valve replacement (cAVR) and no studies where both were inserted via full sternotomy. As such, we reviewed our experience and compared the two approaches. METHODS: From 2008 to 2015, 597 patients underwent isolated aortic valve replacement ± coronary artery bypass grafting (CABG) at a single centre. During this period, 41 (7%) patients received RD-AVR and 556 (93%) received cAVR. Of those receiving RD-AVR, surgical access was via full median sternotomy in 40 (98%). Propensity score matching yielded 41 matched pairs. Perioperative outcomes were compared. RESULTS: After propensity score matching, the RD-AVR group had shorter aortic cross clamp (X-clamp) (RD-AVR: 71±33min vs. cAVR: 106±42min, p<0.01) and cardiopulmonary bypass (CPB) times (95±42min vs. 134±47min, p<0.01). There was no difference in 30-day mortality (RD-AVR: 2% vs. cAVR: 2%, p>0.99). RD-AVR patients required shorter mean ventilation (17±25 vs. 63±131hrs, p<0.01) and intensive care unit (ICU) stay (51±45 vs. 108±157hrs, p=0.03) times. RD-AVR also had reduced rates of new postoperative atrial arrhythmias (8% vs. 20%, p=0.02). Total length of postoperative hospital stay was similar. Haemodynamic performance for the RD-AVR was within acceptable limits. CONCLUSIONS: The use of RD-AVR results in shorter X-clamp and CPB times and is associated with reductions in perioperative morbidity. RD-AVR is becoming a valuable component of the surgeon's armamentarium in selected patients. Long-term follow-up will reveal the full potential of these devices.


Subject(s)
Aortic Valve Stenosis , Aortic Valve/surgery , Arrhythmias, Cardiac/physiopathology , Bioprosthesis , Cardiopulmonary Bypass/adverse effects , Heart Valve Prosthesis Implantation/adverse effects , Postoperative Complications/physiopathology , Aged , Aged, 80 and over , Aortic Valve Stenosis/physiopathology , Aortic Valve Stenosis/surgery , Arrhythmias, Cardiac/etiology , Female , Humans , Length of Stay , Male , Middle Aged , Sternotomy/adverse effects
4.
J Cardiothorac Vasc Anesth ; 28(2): 242-6, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24439890

ABSTRACT

OBJECTIVES: Bleeding into the chest is a major cause of blood transfusion and adverse outcomes following cardiac surgery. The authors investigated predictors of bleeding following cardiac surgery to identify potentially correctable factors. DESIGN: Data were retrieved from the medical records of patients undergoing cardiac surgery over the period of 2002 to 2008. Multivariate analysis was used to identify the independent predictors of chest tube drainage. SETTING: Tertiary hospital. PARTICIPANTS: Two thousand five hundred seventy-five patients. INTERVENTIONS: Cardiac surgery. RESULTS: The individual operating surgeon was independently associated with the extent of chest tube drainage. Other independent factors included internal mammary artery grafting, cardiopulmonary bypass time, urgency of surgery, tricuspid valve surgery, redo surgery, left ventricular impairment, male gender, lower body mass index and higher preoperative hemoglobin levels. Both a history of diabetes and administration of aprotinin were associated with reduced levels of chest tube drainage. CONCLUSIONS: The individual operating surgeon was an independent predictor of the extent of chest tube drainage. Attention to surgeon-specific factors offers the possibility of reduced bleeding, fewer transfusions, and improved patient outcomes.


Subject(s)
Cardiac Surgical Procedures/methods , Chest Tubes/statistics & numerical data , Drainage/statistics & numerical data , Physicians , Postoperative Hemorrhage/epidemiology , Aged , Aged, 80 and over , Antifibrinolytic Agents/adverse effects , Antifibrinolytic Agents/therapeutic use , Aprotinin/adverse effects , Body Mass Index , Cardiopulmonary Bypass , Female , Hemoglobins/analysis , Hemoglobins/metabolism , Hemostatics/adverse effects , Humans , Male , Mammary Arteries/transplantation , Middle Aged , Multivariate Analysis , Postoperative Hemorrhage/therapy , Radial Artery/transplantation , Reoperation/statistics & numerical data , Sex Factors , Tricuspid Valve/surgery , Ventricular Dysfunction, Left/physiopathology
5.
Heart Lung Circ ; 23(1): 91-5, 2014 Jan.
Article in English | MEDLINE | ID: mdl-23948288

ABSTRACT

Current surgical management of restrictive ischaemic mitral regurgitation (IMR) includes mitral valve annuloplasty (MVA) using an undersized ring when the mechanism is secondary to leaflet restriction. In our experience, MVA alone is inadequate to eliminate mitral incompetence in these patients. We report the 'Down-Under Repair' as an adjunctive concept for the treatment of a subset of patients with restrictive IMR and associated inferobasal left ventricular aneurysm. The 'Down-Under Repair' reduces mitral leaflet restriction by approximating the origin of the posterior papillary muscle towards the mitral annulus. Midterm results demonstrated sustained valvular competence and symptomatic improvement.


Subject(s)
Mitral Valve Annuloplasty/methods , Mitral Valve Insufficiency/surgery , Myocardial Ischemia/surgery , Aged , Humans , Male , Middle Aged , Mitral Valve Insufficiency/complications , Mitral Valve Insufficiency/pathology , Mitral Valve Insufficiency/physiopathology , Myocardial Ischemia/complications , Myocardial Ischemia/pathology , Myocardial Ischemia/physiopathology , Retrospective Studies
6.
Heart Lung Circ ; 23(8): 711-6, 2014 Aug.
Article in English | MEDLINE | ID: mdl-24726002

ABSTRACT

BACKGROUND: Cardiac troponins are frequently measured as part of the pre-operative work-up of patients prior to coronary artery bypass graft surgery (CABG). The utility of measuring these levels in elective patients, and the clinical implication of an abnormal result are unclear. The following study investigates the relationship between cardiac troponin I (cTnI) measured as part of a routine pre-operative work-up and outcomes following CABG. METHODS: From January 2010 to December 2012, 378 patients underwent isolated, elective CABG and had cTnI measured prospectively, as part of their pre-operative work-up. Patients were divided into normal (Group I) and elevated (Group II) cTnI groups. Pre-operative, operative and post-operative data were obtained from our institution's prospectively collected database. RESULTS: Elevated cTnI was present in 47 patients (12.4%) pre-operatively. Intra-operative variables did not differ between the elevated cTnI and control groups. Both 30-day mortality (Group I: 0.9% v Group II: 6.4%, p=0.03) and cardiac arrest (Group I: 1.5% v Group II: 8.5%, p=0.01) were significantly more frequent in the elevated cTnI group. In multivariable analysis, elevated cTnI remained a predictor for cardiac arrest (OR 5.8, 95% CI 1.2 - 29.2). CONCLUSIONS: Patients presenting for elective CABG frequently have elevated cTnI on pre-operative work-up. These patients may be at a greater risk of 30-day mortality and cardiac arrest. Routine pre-operative measurement of cTnI may alert clinicians to a higher operative risk.


Subject(s)
Coronary Artery Bypass/adverse effects , Databases, Factual , Elective Surgical Procedures/adverse effects , Myocardial Ischemia , Preoperative Care , Troponin I/blood , Aged , Disease-Free Survival , Female , Follow-Up Studies , Humans , Male , Middle Aged , Myocardial Ischemia/blood , Myocardial Ischemia/mortality , Myocardial Ischemia/surgery , Survival Rate , Time Factors
7.
Transfusion ; 53(1): 19-27, 2013 Jan.
Article in English | MEDLINE | ID: mdl-22574710

ABSTRACT

BACKGROUND: Bleeding into the chest is a life-threatening complication of cardiac surgery. Blood transfusion has been implicated as an important cause of harm associated with bleeding, based largely on studies demonstrating an independent association between transfusion and mortality. These studies did not, however, consider the possibility that bleeding may in itself be harmful, inasmuch as drains are inefficient at clearing blood from the chest and retained blood may compromise cardiac and lung function. STUDY DESIGN AND METHODS: We undertook a multivariate logistic regression analysis of the risk factors associated with mortality in 2599 consecutive patients undergoing cardiac surgery. Unlike previous studies the risk factors examined included the volume of chest tube drainage at 24 hours. A stratified analysis was also undertaken that compared the adjusted risk of death for patients exposed or not exposed to a postoperative blood transfusion. RESULTS: Blood transfusion was not an independent predictor of mortality (p=0.4). Chest tube drainage was the strongest independent predictor of mortality (p<0.001). In the stratified analysis, chest tube drainage remained an independent predictor of mortality for patients not exposed to a blood transfusion (p<0.01). Furthermore, the risk of death of these patients was no different from patients exposed to a blood transfusion (p=0.7 for interaction). CONCLUSIONS: Our results argue that for patients undergoing cardiac surgery bleeding contributes to mortality through mechanisms unrelated to blood transfusion.


Subject(s)
Cardiac Surgical Procedures/mortality , Transfusion Reaction , Aged , Female , Humans , Logistic Models , Male , Middle Aged , Regression Analysis , Retrospective Studies , Risk Factors
9.
Resuscitation ; 76(2): 311-3, 2008 Feb.
Article in English | MEDLINE | ID: mdl-17765383

ABSTRACT

INTRODUCTION: Therapeutic hypothermia after resuscitation improves outcome following prolonged out-of-hospital cardiac arrest. Laboratory studies suggest that this therapy may improve outcome further when induced during cardiopulmonary resuscitation. We report a case where therapeutic hypothermia was induced during cardiopulmonary resuscitation using large-volume (40 mL/kg), ice-cold (4 degrees C) intravenous fluid. DESIGN: Case report. SETTING: A tertiary level hospital in Victoria, Australia. CASE REPORT: The patient suffered a cardiac arrest secondary to pericardial tamponade following right ventricular perforation during cardiac catheterisation. Percutaneous needle drainage was unsuccessful and open drainage via a left emergency thoracotomy was performed. Therapeutic hypothermia during cardiopulmonary resuscitation was induced using of a rapid infusion of large-volume (40 mL/kg), ice-cold (4 degrees C) crystalloid fluid. A spontaneous circulation was restored after 37 min of cardiac arrest. The patient made a satisfactory neurological recovery. CONCLUSION: Treatment with a rapid intravenous infusion of large-volume (40 mL/kg), ice-cold (4 degrees C) fluid during cardiopulmonary resuscitation induces mild hypothermia and may provide neurological protection. Further clinical studies of this approach are warranted.


Subject(s)
Cardiopulmonary Resuscitation/methods , Heart Arrest/therapy , Hypothermia, Induced/methods , Isotonic Solutions/administration & dosage , Body Temperature , Cardiac Tamponade/therapy , Emergency Medical Services , Female , Heart Arrest/physiopathology , Humans , Infusions, Intravenous , Middle Aged , Temperature
10.
Eur J Cardiothorac Surg ; 50(1): 53-60, 2016 Jul.
Article in English | MEDLINE | ID: mdl-26792919

ABSTRACT

OBJECTIVES: The use of bilateral internal thoracic arteries (BITAs) is associated with improved long-term survival after coronary artery bypass grafting (CABG). However, it is unclear whether the addition of a radial artery (RA) in patients already receiving BITA confers any additional survival benefit over that of a saphenous vein (SV). As such, we reviewed our multicentre experience and compared both strategies. METHODS: From 1995 to 2010, 1497 patients underwent primary isolated CABG for three-vessel coronary disease using BITAs. An SV was used as a third conduit in 460 (31%) patients and an RA in 1037 (69%). A total of 1258 distal anastomoses were performed using RAs and these were to the diagonal territory in 169, the circumflex in 454 and the right coronary in 635. Survival data were obtained using the National Death Index and propensity-score matching was used for risk-adjustment. RESULTS: The overall cohort was young (mean age 61 ± 9 years). Patients receiving RAs were more likely to be younger, and were less likely to have experienced a prior myocardial infarction. At 30 days, mortality was similar (BITA + SV: 5, 1.1% vs BITA + RA: 9, 0.9%, P = 0.77). At 15 years, BITA + RA patients experienced improved unadjusted survival (BITA + SV: 67 ± 4.6% vs BITA + RA: 82 ± 3.2%, P < 0.0001). Multivariable Cox regression in the entire cohort also showed the BITA + RA group to be associated with better survival (HR 0.58, 95% CI 0.44-0.75, P < 0.001). After propensity-score matching of 262 patient-pairs, BITA + RA experienced similar 30-day mortality (BITA + SV: 3, 1.1% vs BITA + RA: 3, 1.1%, P > 0.99). However, at 15 years, BITA + RA patients experienced improved risk-adjusted survival (BITA + SV: 72 ± 6.0% vs BITA + RA: 82 ± 5.2%, P = 0.021). The RA was associated with better risk-adjusted survival for grafting of the right coronary and its branches (148 matched pairs; SV-RCA: 74 ± 7.8% vs RA-RCA: 86 ± 6.5%, P = 0.0046 at 15 years). CONCLUSIONS: The addition of an RA graft even in patients already receiving BITAs is associated with a survival benefit. In younger patients with a reasonable long-term life expectancy, surgeons should strive to achieve total arterial revascularization with BITAs and radial arteries.


Subject(s)
Coronary Artery Bypass/methods , Coronary Disease/surgery , Radial Artery/transplantation , Saphenous Vein/transplantation , Adult , Aged , Aged, 80 and over , Coronary Artery Bypass/mortality , Coronary Disease/mortality , Humans , Internal Mammary-Coronary Artery Anastomosis/methods , Internal Mammary-Coronary Artery Anastomosis/mortality , Middle Aged , Treatment Outcome
11.
Eur J Cardiothorac Surg ; 49(1): 196-202, 2016 Jan.
Article in English | MEDLINE | ID: mdl-25669645

ABSTRACT

OBJECTIVES: Studies suggest that the radial artery (RA) may exhibit superior patency compared with the saphenous vein (SV). It is unclear whether older patients undergoing coronary artery bypass grafting (CABG) derive any survival benefit from the use of RAs. We sought to evaluate this using a multicentre database. METHODS: From 1995 to 2010, 6059 patients with three-vessel coronary artery disease underwent primary isolated CABG at 8 centres. A study cohort of 4006 patients was formed with 3220 (80%) receiving at least 1 RA to supplement a single in situ internal thoracic artery (RA group) while 786 (20%) received only veins to supplement a single ITA (SV group). In the RA group, bilateral RAs were used in 1418 (44%) cases, while total arterial revascularization was achieved in 1859 (58%). RAs were mostly grafted to the left circumflex and right coronary territories. Survival data were obtained using the National Death Index and propensity-score matching was used for risk adjustment. Separate propensity-score analyses were conducted for the 2149 patients (1645 RA, 504 SV) who were 70 years or older. RESULTS: Patients receiving RAs were younger (mean age in years RA: 68 ± 9.7 vs SV: 71 ± 7.9, P < 0.001) and less likely to have cerebrovascular disease, obstructive airways disease, myocardial infarction within 7 days and left-main coronary disease. At 30 days, RA patients experienced reduced unadjusted mortality (49 of 3220, 1.5% vs 25 of 786, 3.2%, P = 0.004). At 15 years, the RA group showed superior unadjusted survival (51 ± 1.1 vs 35 ± 1.9%, P < 0.001). After propensity-score matching of 507 patient pairs, there was comparable 30-day mortality between groups (RA: 9, 1.8 vs SV: 14, 2.8%, P = 0.41). However, at 15 years, the RA group still showed superior survival (42 ± 2.6 vs 35 ± 2.5%, P = 0.008). Among those 70 years and older (327 matched pairs), despite similar 30-day mortality (RA: 6, 1.8% vs SV: 10, 3.1%, P = 0.42), RA patients again exhibited improved survival (35 ± 3.3 vs 22 ± 2.8%, P = 0.004) at 15 years. CONCLUSIONS: This multicentre analysis suggests that the use of an RA is associated with a survival benefit in older patients undergoing CABG.


Subject(s)
Coronary Artery Bypass/methods , Coronary Artery Disease/surgery , Radial Artery/transplantation , Adult , Age Factors , Aged , Aged, 80 and over , Coronary Artery Bypass/mortality , Coronary Artery Disease/mortality , Female , Humans , Male , Middle Aged , Propensity Score , Retrospective Studies , Survival Analysis , Treatment Outcome
12.
ANZ J Surg ; 85(11): 878-81, 2015 Nov.
Article in English | MEDLINE | ID: mdl-26331481

ABSTRACT

BACKGROUND: Deep sternal wound infection (DSWI) is a rare but life-threatening complication following cardiac surgery associated with increased morbidity and mortality. Management of these patients has evolved over the years and can include sternal rewiring, mediastinal irrigation, negative-pressure wound therapy (NPWT) dressing or repair with flaps. We reviewed changes in our management of DSWI and outcomes. METHODS: Using the Australian and New Zealand Society of Cardiac and Thoracic Surgeons database, 5472 underwent cardiac surgery at St Vincent's Hospital, Melbourne, and 42 were identified as developing DSWI requiring re-operation between June 2002 and September 2014. Data were collected pertaining to risk factors for DSWI, management strategies and outcomes. Patients were compared from a period prior to NPWT dressing use (June 2002-February 2006, n = 14) and since the NPWT has been used regularly in the management of DSWI (from March 2006, n = 28). Patients were also compared based on the requirement for flap closure of their sternal wound. RESULTS: Because of the widespread use of NPWT dressings, there is a trend towards fewer sternal infections requiring flap closure (25 versus 42.8%) and less post-operative complications after definitive closure (7.1 versus 28.6%). Before and after widespread NPWT use, patients require similar number of re-operations before closure and have no significant differences in time to definitive closure or length of hospital stay. CONCLUSION: The use of NPWT dressings as a bridge to definitive closure may reduce the need for more burdensome flap reconstruction, does not delay definitive reconstruction or prolong hospital stay and may reduce post-reconstruction complications requiring re-operation.


Subject(s)
Cardiac Surgical Procedures , Negative-Pressure Wound Therapy/statistics & numerical data , Practice Patterns, Physicians'/trends , Sternotomy , Surgical Wound Infection/therapy , Aged , Australia , Combined Modality Therapy , Databases, Factual , Female , Humans , Male , Negative-Pressure Wound Therapy/trends , New Zealand , Plastic Surgery Procedures/statistics & numerical data , Plastic Surgery Procedures/trends , Reoperation , Retrospective Studies , Risk Factors , Surgical Flaps/statistics & numerical data , Surgical Flaps/trends , Surgical Wound Infection/etiology , Therapeutic Irrigation/statistics & numerical data , Therapeutic Irrigation/trends , Treatment Outcome , Wound Healing
13.
J Thorac Cardiovasc Surg ; 150(6): 1526-33, 1534.e1-3; discussion 1533-4, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26211406

ABSTRACT

OBJECTIVE: Total arterial revascularization (TAR) with internal thoracic arteries (ITAs) and radial arteries (RA) is associated with greater long-term survival compared with the use of a single internal thoracic artery supplemented by veins. The optimal conduit choice and configuration in achieving TAR remains controversial, with uncertainty regarding the individual prognostic impact of ITAs and RAs. As such, among patients solely undergoing TAR, we compared long-term survival between patients receiving single thoracic arteries and those receiving bilateral ITAs. METHODS: From 1995 to 2010, 2821 patients with 3-vessel coronary artery disease at 8 centers underwent primary isolated coronary artery bypass with TAR using ITAs and RAs. Bilateral ITAs were used in 912 patients. In 380 cases, bilateral in situ ITAs were grafted to the left coronary system. RAs were used in 848 patients (93%) receiving bilateral ITAs and 1906 patients (99.8%) receiving single ITAs. Survival data were obtained using the National Death Index. Separate 1:1 propensity score-matched analyses were performed for (1) bilateral ITA versus single ITA and (2) bilateral ITA incorporating a free right ITA versus single ITA and RAs. Among the 912 patients with bilateral ITAs, those receiving an in situ right ITA to the left coronary system were compared with those receiving a free right ITA. RESULTS: In the propensity score-matched analysis comparing bilateral versus single ITAs (591 matched pairs), there were similar rates of 30-day mortality and deep sternal wound infection. Bilateral ITA use was associated with greater 15-year survival (79% ± 3.9% vs 67% ± 4.7%, P < .001). In the analysis between bilateral ITA incorporating a free right ITA versus single ITA + RAs (380 matched pairs), bilateral ITA use demonstrated comparable survival at 15 years (79% ± 4.7% vs 67% ± 5.7%, P = .09). Among patients receiving bilateral ITAs, comparison between in situ right ITA versus free right ITA recipients (206 matched pairs) revealed comparable 15-year survival (84% ± 6.1% vs 79% ± 6.7%, P = .13). Multivariable Cox regression found bilateral ITA use to be protective from mortality (hazard ratio, 0.73; 95% confidence interval, 0.59-0.90, P = .004). CONCLUSIONS: The use of bilateral ITAs as an in situ or free conduit is associated with greater survival and seems to offer a prognostic advantage over the use of only a single ITA supplemented by RAs. Therefore, all configurations of TAR are not equivalent.


Subject(s)
Coronary Artery Disease/surgery , Internal Mammary-Coronary Artery Anastomosis/methods , Radial Artery/transplantation , Thoracic Arteries/transplantation , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Propensity Score , Survival Analysis , Treatment Outcome
14.
Ann Thorac Surg ; 73(4): 1316-7, 2002 Apr.
Article in English | MEDLINE | ID: mdl-11996286

ABSTRACT

A 47-year-old diabetic man with unstable angina underwent coronary bypass surgery using bilateral radial arteries and left internal thoracic artery. After surgery, the patient suffered from severe right arm pain and swelling without any bleeding. The postoperative immediate digital subtraction angiogram detected thrombotic occlusion of the right axillary vein. We report here a rare case of deep vein thombosis related to radial artery harvesting.


Subject(s)
Axillary Vein , Radial Artery/transplantation , Tissue and Organ Harvesting/adverse effects , Venous Thrombosis/etiology , Angiography, Digital Subtraction , Axillary Vein/diagnostic imaging , Coronary Artery Bypass , Humans , Male , Middle Aged , Venous Thrombosis/diagnostic imaging
15.
Ann Thorac Surg ; 75(1): 62-7, 2003 Jan.
Article in English | MEDLINE | ID: mdl-12537194

ABSTRACT

BACKGROUND: It is unknown whether coronary artery bypass grafting without cardiopulmonary bypass and with exclusive use of arterial grafts (arterial off-pump CABG) offers any significant short-term advantages over standard CABG with cardiopulmonary bypass. Accordingly, we performed a comparison of the short-term outcomes of arterial off-pump and standard CABG patients matched for preoperative risk and number of grafts. METHODS: We studied 90 consecutive arterial off-pump CABG patients during a 2-year period, obtained demographic and clinical features and surgical characteristics, and calculated their predicted surgical risk (EuroSCORE). Using a database of 750 contemporaneous patients treated with standard CABG, we created a matched cohort of 90 patients using an iterative process prioritizing number of grafts, target vessels, EuroSCORE, age, and sex. We compared the two groups for baseline features and short-term clinical outcomes. RESULTS: There were no differences in age (65.9 versus 64.7 years), sex, EuroSCORE (3.3 versus 3. 6), number of grafts (2.1 versus 2.1), and preoperative left ventricular function. Arterial off-pump CABG, however, was associated with decreased duration of operation (213 versus 252 minutes; p < 0.0013), decreased peak postoperative troponin I levels (mean, 10.8 versus 29.1 ng/mL; p < 0.0001), decreased peak norepinephrine dose (2.3 versus 4.1 microg/ min; p < 0.0082), and decreased likelihood of receiving red blood cell transfusion (17.8% versus 40%; p = 0.0016). There were no differences in duration of intensive care unit or hospital stay, incidence of atrial fibrillation, or other clinical complications. There was one death in each group. CONCLUSIONS: After matching for number of grafts and other important preoperative risk markers, arterial off-pump CABG still decreases the need for red blood cell transfusion and offers other moderate clinical advantages compared with standard on-pump CABG.


Subject(s)
Cardiopulmonary Bypass , Coronary Artery Bypass/methods , Aged , Blood Transfusion , Female , Humans , Intensive Care Units , Length of Stay , Male , Middle Aged , Norepinephrine/blood , Treatment Outcome , Troponin I/blood
16.
ANZ J Surg ; 74(11): 983-5, 2004 Nov.
Article in English | MEDLINE | ID: mdl-15550088

ABSTRACT

BACKGROUND: Early and late results were studied in order to improve the indications for surgery in the elderly. METHODS: Two hundred and thirty-seven patients aged 80 years or older underwent cardiac surgery between 1987 and 2001. The mean age of patients, which included 148 men and 89 women, was 82 years. Elective operations were performed in 194 patients and urgent or emergency operations in 43. Coronary artery bypass grafting (CABG) was performed in 104 patients, valve surgery in 60, CABG plus valve in 58, and other surgery in 15. Late results were obtained in 91% of patients, and the mean follow-up period was 54 months. RESULTS: Operative mortality was 9% in total; 7% in CABG, 5% in valve, 10% in CABG plus valve. Operative mortality was significantly higher in the urgent/emergency group than in the elective group (25% vs 6%). The actuarial survival rate for hospital survivors at 60 months after surgery was 75% and the mean survival period 76 months. There were no significant differences among operations. Preoperatively 81% of the patients had been in New York Heart Association class III or IV, and 88% of survivors were in class I or II in the late period. CONCLUSIONS: Early and late results for elective surgery in octogenarians are satisfactory. However, for urgent or emergent cases, there is a marked increase in morbidity and mortality.


Subject(s)
Cardiac Surgical Procedures , Actuarial Analysis , Aged , Aged, 80 and over , Cardiac Surgical Procedures/mortality , Cardiac Surgical Procedures/statistics & numerical data , Coronary Artery Bypass/mortality , Coronary Artery Bypass/statistics & numerical data , Elective Surgical Procedures , Emergencies , Female , Heart Valve Prosthesis Implantation/mortality , Heart Valve Prosthesis Implantation/statistics & numerical data , Humans , Male , Postoperative Complications/epidemiology , Survival Rate , Victoria
17.
Ann Thorac Cardiovasc Surg ; 8(6): 354-7, 2002 Dec.
Article in English | MEDLINE | ID: mdl-12517295

ABSTRACT

BACKGROUND: The aim of this study is to review our experience with using more than 2,000 RAs over the last seven years, and to assess the medium-term outcome in terms of morbidity and mortality. METHODS: Between June 1994 and June 2001, a total of 2,024 RAs have been used in 1,613 patients. The mean duration of follow-up was 40.1 months and ranged from one to 88 months. We assessed the results of postoperative mortality and morbidity, RA graft patency, coronary event free rate, and actuarial survival rate. Specifically, the independent predictors of early and late mortalities were examined. RESULTS: Perioperative myocardial infarction was indicated in 0.8%, stroke in 1.6%, respectively. Overall hospital mortality was 35 patients (2.4%). RA patency rate was 98.1%. Coronary event free rate and actuarial survival rates at seven years were 99.6% and 95.1%, respectively. Multivariate logistic regression analysis detected an ejection fraction of less than 30% (p=0.0009), re-exploration (p=0.02), and stroke (p=0.03) as significant independent predictors of operative mortality. The use of saphenous vein graft (p=0.0417) and renal impairment (p=0.0045) were significant independent predictors of late mortality. CONCLUSIONS: Our seven-year experience of CABG with RA suggested that the use of RA was safe and had excellent results in postoperative graft patency and low incidence of complications. This study suggested that the use of RA instead of the saphenous vein graft made a better outcome for late survival in the patients undergoing CABG.


Subject(s)
Coronary Artery Bypass/mortality , Radial Artery/transplantation , Adult , Aged , Aged, 80 and over , Coronary Artery Bypass/adverse effects , Coronary Artery Bypass/methods , Female , Humans , Logistic Models , Male , Middle Aged , Retrospective Studies , Risk Factors , Treatment Outcome , Vascular Patency
18.
Ann Thorac Cardiovasc Surg ; 9(4): 241-4, 2003 Aug.
Article in English | MEDLINE | ID: mdl-13129422

ABSTRACT

OBJECTIVE: Recent studies have suggested that increased left ventricular (LV) size is a risk factor for perioperative mortality in patients with low ejection fraction (EF) undergoing coronary artery bypass surgery (CABG). We previously presented a new method of LV reconstruction, called geometric endoventricular repair (GER) as representing a physiologically effective repair. The aim of this study is to assess whether GER confers benefits compared to patients undergoing CABG alone. METHODS: Between July 1996 and July 2001, 110 patients with a low EF of less than 35% documented by radionuclide ventriculogram (RNVG) underwent CABG in Austin Hospital, Australia, and were divided into two groups. Group I consisted of 52 patients undergoing isolated CABG. Group II comprised 58 patients undergoing CABG and GER. We compared the two groups in terms of EF, NYHA class, incidence of recurrent heart failure, and mortality. RESULTS: Preoperative EF was 27.7+/-6.1% in group I and 27.4+/-5.7% in group II, respectively (NS), with significant improvement in both groups (33.8+/-13.0% in group I, 35.1+/-13.3% in group II). NYHA class was also significantly improved postoperatively (from 3.3 to 1.8 in group I, and 3.6 to 1.7 in group II). There were 15 patients (28.8%) hospitalized for heart failure in group I, postoperatively, compared to seven patients (10.9%) in group II (p=0.026). Cardiac event-free survival rate at 28 months (mean follow-up) was also significantly higher in group II (88.9% in group II vs. 70.6% in group I, p=0.05). The actuarial survival rate at 31 months (mean follow-up) was 88.2% in group I and 95.3% in group II, respectively (NS). CONCLUSIONS: LV reconstruction along with CABG for ischemic ventricular dysfunction may provide symptomatic and cardiac event free survival benefits, compared to CABG alone.


Subject(s)
Coronary Artery Bypass/methods , Myocardial Ischemia/surgery , Ventricular Dysfunction, Left/surgery , Aged , Coronary Artery Bypass/adverse effects , Follow-Up Studies , Heart Ventricles/pathology , Heart Ventricles/surgery , Humans , Middle Aged , Myocardial Ischemia/mortality , Myocardial Ischemia/pathology , Survival Rate , Time Factors , Treatment Outcome , Ventricular Dysfunction, Left/mortality , Ventricular Dysfunction, Left/pathology
19.
Ann Thorac Cardiovasc Surg ; 8(2): 97-101, 2002 Apr.
Article in English | MEDLINE | ID: mdl-12027796

ABSTRACT

INTRODUCTION: Despite renewed clinical interest in radial artery grafts (RA) for coronary artery bypass grafting, there is a paucity of controlled prospective data on its efficacy. We report on the rate of harvest related complications from a randomized radial artery study. METHODS: Two hundred eighty nine patients were divided into two groups. Group 1 received RA grafts (n=154 patients) and Group 2 (n=135 patients) received saphenous vein grafts (SVG). Postoperative wound problems were assessed using a questionnaire. Postoperative harvest site infections were also carefully documented. RESULTS: In group 1, 6 of 154 (3.9%) patients had harvest site wound infections. Five of them improved by antibiotic therapy alone. In group 2, 24 of 135 (17.8%) patients had harvest site wound infections (p=0.001 vs. group 1). Fifteen of these patients needed redressing due to discharge from the wound. One hundred forty-nine patients (96.7%) in group 1 answered that their hand function was normal on the questionnaire. Concerns and discomfort about the arm scars in the group 1 were of a similar value of 5.2% (8/154), respectively. In group 2, the incidence of those about the leg were 7.4% (10/135) and 11.9% (16/135), respectively. Although there was no significant difference in concerns about the scar, discomfort was significantly higher in group 2 compared with group 1 (p=0.0139). CONCLUSIONS: RA harvest is associated with fewer wound infections and scar discomfort than SVG harvest. Radial artery harvest is almost acceptable in terms of a patient's perception. However, there are still patients who have some symptoms in the forearm after RA harvest. Long-term follow-up is necessary for patient's hand function.


Subject(s)
Patient Satisfaction , Surgical Wound Infection/etiology , Aged , Australia/epidemiology , Body Mass Index , Coronary Artery Bypass , Female , Follow-Up Studies , Forearm/blood supply , Forearm/surgery , Humans , Leg/blood supply , Leg/surgery , Male , Middle Aged , Prevalence , Radial Artery/transplantation , Saphenous Vein/transplantation , Surgical Wound Infection/epidemiology , Treatment Outcome
20.
J Thorac Cardiovasc Surg ; 148(4): 1238-43; discussion 1243-4, 2014 Oct.
Article in English | MEDLINE | ID: mdl-25131165

ABSTRACT

OBJECTIVES: We sought to evaluate our experience with total arterial revascularization and compare it with the traditional approach of a single internal thoracic artery supplemented by saphenous veins. METHODS: From 1995 to 2010, 6059 patients with triple-vessel coronary artery disease underwent primary isolated coronary artery bypass grafting at 8 centers. A study cohort of 3774 patients was formed, with 2988 (79%) undergoing total arterial revascularization and 786 (21%) receiving only saphenous veins to supplement a single in situ internal thoracic artery. In the total arterial revascularization group, bilateral internal thoracic arteries were used in 1079 patients (36%) and at least 1 radial artery was used in 2916 patients (97%). Propensity score matching was used for risk adjustment. RESULTS: Patients undergoing total arterial revascularization were younger (65.0±10.4 years vs 71.3±7.9 years, P<.001) and less likely to have diabetes, cerebrovascular disease, recent myocardial infarction, and severe left ventricular impairment. At 15 years, patients who underwent total arterial revascularization experienced superior unadjusted survival (62%±1.1% vs 35%±1.9%, P<.001). Multivariable Cox regression in the entire study cohort showed the total arterial group had improved survival with a hazard ratio of 0.79 (95% confidence interval, 0.70-0.90; P<.001). After propensity score matching yielded 384 patient pairs, patients who underwent total arterial revascularization showed improved survival at 15 years than patients who underwent single arterial revascularization (54%±3.3% vs 41%±3.0%, P=.0004). CONCLUSIONS: This large multicenter study suggests that a strategy of total arterial revascularization is associated with improved long-term survival compared with the use of only a single arterial and saphenous vein grafts. Total arterial revascularization should be encouraged in patients with a reasonable life expectancy.


Subject(s)
Coronary Artery Disease/surgery , Internal Mammary-Coronary Artery Anastomosis/methods , Mammary Arteries/transplantation , Myocardial Revascularization/methods , Radial Artery/transplantation , Aged , Aged, 80 and over , Australia/epidemiology , Coronary Artery Bypass , Coronary Artery Disease/mortality , Female , Hospital Mortality , Humans , Internal Mammary-Coronary Artery Anastomosis/mortality , Male , Middle Aged , Myocardial Revascularization/mortality , Propensity Score , Risk Factors , Sternotomy
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