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CALR-mutated patients with low allele burden represent a specific subtype of essential thrombocythemia: A study on behalf of FIM and GBMHM.

Aubin, Laura; Vilas Boas, Rúben; Daltro De Oliveira, Rafael; Le Brun, Valoris; Divoux, Marion; Rey, Jérôme; Mansier, Olivier; Ianotto, Jean-Christophe; Pastoret, Cédric; Desmares, Anne; Murati, Anne; de Mas, Véronique; Tavitian, Suzanne; Girodon, François; Soret Dulphy, Juliette; Maslah, Nabih; Goncalves Monteiro, Valérie; Boyer, Françoise; Orvain, Corentin; Ranta, Dana; Cayssials, Émilie; Le Clech, Lenaig; Nicol, Christophe; Rottier, Camille; Botin Lopez, Teresa; Castel, Brice; Rispal, Patrick; Beziat, Guillaume; Bescond, Charles; Laribi, Kamel; Benajiba, Lina; Ugo, Valérie; Lippert, Eric; Cottin, Laurane; Luque Paz, Damien.

Am J Hematol ; 99(5): 1001-1004, 2024 05.

Article in English | MEDLINE | ID: mdl-38404143

ABSTRACT

A low allele burden (i.e., <20%) of the CALR driver mutation is found in 10.8% of CALR-mutated MPNs, mostly in essential thrombocythemia, and correlates with a milder phenotype and a more indolent evolution compared to patients with an allele burden ≥20%.

Subject(s)

Thrombocythemia, Essential , Humans , Alleles , Calreticulin/genetics , Janus Kinase 2/genetics , Mutation , Phenotype , Thrombocythemia, Essential/genetics

Flow cytometry as a fast, cost-effective tool to assess IGHV mutational status in CLL.

Couillez, Guillaume; Morel, Pierre; Clichet, Valentin; Fourdrain, Ludivine; Delette, Caroline; Harrivel, Véronique; Gubler, Brigitte; Rottier, Camille; Derreumaux, Sophie; Margat, Emilie; Garcon, Loic; Marolleau, Jean-Pierre; Boyer, Thomas.

Blood Adv ; 7(17): 4701-4704, 2023 09 12.

Article in English | MEDLINE | ID: mdl-36287221

Subject(s)

Leukemia, Lymphocytic, Chronic, B-Cell , Humans , Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis , Leukemia, Lymphocytic, Chronic, B-Cell/genetics , Flow Cytometry , Cost-Benefit Analysis , Mutation , Immunoglobulin Heavy Chains/genetics

ABSTRACT

Subject(s)

Subject(s)

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